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Details on Person UniProt:Q9Y587 AP4S1
| Class:Id | ReferenceGeneProduct:49334 |
|---|---|
| _chainChangeLog | chain:1-144 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y587 AP4S1 |
| _timestamp | 2024-11-03 19:35:06 |
| chain | chain:1-144 |
| checksum | 0B620AFBB3B7F8A1 |
| comment | FUNCTION Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).SUBUNIT Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).SUBCELLULAR LOCATION Widely expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the adaptor complexes small subunit family. |
| description | recommendedName: fullName evidence="7"AP-4 complex subunit sigma-1 alternativeName: AP-4 adaptor complex subunit sigma-1 alternativeName: Adaptor-related protein complex 4 subunit sigma-1 alternativeName: Sigma-1 subunit of AP-4 alternativeName: Sigma-4-adaptin shortName: Sigma4-adaptin |
| geneName | AP4S1 |
| identifier | Q9Y587 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Golgi apparatus Hereditary spastic paraplegia Membrane Neurodegeneration Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AP4S1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998167] ENSEMBL:ENSG00000100478 AP4S1 [Homo sapiens] |
| secondaryIdentifier | AP4S1_HUMAN G3V2N8 Q6IAQ4 Q86U36 Q9BVE7 |
| sequenceLength | 144 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977289] UniProt:Q9Y587-1 AP4S1 [Homo sapiens] [ReferenceIsoform:8977290] UniProt:Q9Y587-2 AP4S1 [Homo sapiens] [ReferenceIsoform:8977291] UniProt:Q9Y587-3 AP4S1 [Homo sapiens] [ReferenceIsoform:8977292] UniProt:Q9Y587-4 AP4S1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5215967] AP4S1 [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:5229155] AP4S1 [endosome lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y587 AP4S1 (49334)
