Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9UPM8 AP4E1
| Class:Id | ReferenceGeneProduct:49324 |
|---|---|
| _chainChangeLog | chain:1-1137 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UPM8 AP4E1 |
| _timestamp | 2024-11-03 19:35:06 |
| chain | chain:1-1137 |
| checksum | 1784E886EC922875 |
| comment | FUNCTION Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).SUBUNIT Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1) (PubMed:10066790, PubMed:10436028). Interacts with TEPSIN (PubMed:26542808). Interacts with GRIA2; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity).INTERACTION Widely expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the adaptor complexes large subunit family. |
| description | recommendedName: fullName evidence="12"AP-4 complex subunit epsilon-1 alternativeName: AP-4 adaptor complex subunit epsilon alternativeName: Adaptor-related protein complex 4 subunit epsilon-1 alternativeName: Epsilon subunit of AP-4 alternativeName: Epsilon-adaptin |
| geneName | AP4E1 |
| identifier | Q9UPM8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Golgi apparatus Hereditary spastic paraplegia Membrane Neurodegeneration Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AP4E1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988822] ENSEMBL:ENSG00000081014 AP4E1 [Homo sapiens] |
| secondaryIdentifier | AP4E1_HUMAN A0AVD6 A1L4A9 A6NNX7 H0YKX4 Q68D31 Q9Y588 |
| sequenceLength | 1137 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976368] UniProt:Q9UPM8-1 AP4E1 [Homo sapiens] [ReferenceIsoform:8976369] UniProt:Q9UPM8-2 AP4E1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:434209] AP4E1 [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:434338] AP4E1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:5229075] AP4E1 [endosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:5229094] AP4E1 [trans-Golgi network membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UPM8 AP4E1 (49324)
