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Details on Person UniProt:P01023 A2M
| Class:Id | ReferenceGeneProduct:49292 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-1474 added on Fri February 6 2015 |
| _displayName | UniProt:P01023 A2M |
| _timestamp | 2024-11-03 19:44:27 |
| chain | signal peptide:1-23 chain:24-1474 |
| checksum | 0A46DF09EFD3CF40 |
| comment | FUNCTION Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.SUBUNIT Homotetramer; disulfide-linked.INTERACTION Secreted in plasma.DEVELOPMENTAL STAGE Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels.SIMILARITY Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION Alpha-2 macroglobulin entry |
| description | recommendedName: Alpha-2-macroglobulin shortName: Alpha-2-M alternativeName: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 |
| geneName | A2M CPAMD5 FWP007 |
| identifier | P01023 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Bait region Direct protein sequencing Disulfide bond Glycoprotein Isopeptide bond Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Thioester bond |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | A2M |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957927] ENSEMBL:ENSG00000175899 A2M [Homo sapiens] |
| secondaryIdentifier | A2MG_HUMAN Q13677 Q59F47 Q5QTS0 Q68DN2 Q6PIY3 Q6PN97 |
| sequenceLength | 1474 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:49291] A2M [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:139834] A2M [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:200618] A2M [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01023 A2M (49292)
