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Details on Person UniProt:P63009 AP2B1
| Class:Id | ReferenceGeneProduct:49278 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-937 added on Fri February 6 2015;initiator methionine:1 for 49278 removed on Fri Nov 03 2023;initiator methionine: for 49278 added on Fri Nov 03 2023;initiator methionine: for 49278 removed on Fri Aug 15 2025;initiator methionine:1 for 49278 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63009 AP2B1 |
| _timestamp | 2025-08-15 21:58:48 |
| chain | initiator methionine:1 chain:2-937 |
| checksum | 1BE161EF3B8C07A3 |
| comment | FUNCTION Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity).SUBUNIT adapter protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1) (By similarity). Interacts with EPN1 (By similarity). Interacts with EPS15; clathrin competes with EPS15 (By similarity). Interacts with SNAP91; clathrin competes with SNAP91 (By similarity). Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C (By similarity). Interacts with LDLRAP1 (By similarity). Interacts with AMPH and BIN1 (By similarity). Interacts with ARF6 (GDP-bound) (By similarity). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction (By similarity). Interacts with SLC2A8 (By similarity). Interacts with SCYL1 and SCYL2 (By similarity). Interacts with TGFBR1 and TGFBR2 (By similarity). Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B (By similarity). Interacts with FCHO1 (By similarity). Interacts with RFTN1 (By similarity). Interacts with KIAA1107 (By similarity). Together with AP2A1 or AP2A2 and AP2M1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (By similarity).SUBCELLULAR LOCATION AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.PTM The N-terminus is blocked.PTM Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs).SIMILARITY Belongs to the adaptor complexes large subunit family. |
| description | recommendedName: AP-2 complex subunit beta alternativeName: AP105B alternativeName: Adaptor protein complex AP-2 subunit beta alternativeName: Adaptor-related protein complex 2 subunit beta alternativeName: Beta-2-adaptin alternativeName: Beta-adaptin alternativeName: Clathrin assembly protein complex 2 beta large chain alternativeName: Plasma membrane adaptor HA2/AP2 adaptin beta subunit |
| geneName | AP2B1 CLAPB1 |
| identifier | P63009 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell membrane Coated pit Direct protein sequencing Endocytosis Membrane Phosphoprotein Protein transport Reference proteome Transport |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | AP2B1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AP2B1_BOVIN P21851 |
| sequenceLength | 937 |
| species | [Species:48898] Bos taurus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P63009 AP2B1 (49278)
