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Details on Person UniProt:P08697 SERPINF2
Class:Id
ReferenceGeneProduct:49272
_chainChangeLog
signal peptide:1-27 added on Sat February 7 2015;propeptide:28-39 added on Sat February 7 2015;chain:40-491 added on Sat February 7 2015
_displayName
UniProt:P08697 SERPINF2
_timestamp
2024-11-03 20:13:01
chain
signal peptide:1-27 propeptide:28-39 chain:40-491
checksum
385A1C90E91A63CB
comment
FUNCTION Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.SUBUNIT Forms protease inhibiting heterodimer with TMPRSS7.SUBCELLULAR LOCATION Expressed by the liver and secreted in plasma.PTM Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the serpin family.
Acute phase Alternative splicing Direct protein sequencing Disease variant Disulfide bond Glycoprotein Isopeptide bond Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Sulfation
