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Details on Person UniProt:Q9BXS5 AP1M1
| Class:Id | ReferenceGeneProduct:49250 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-423 added on Fri February 6 2015;initiator methionine:1 for 49250 removed on Fri Nov 03 2023;initiator methionine: for 49250 added on Fri Nov 03 2023;initiator methionine: for 49250 removed on Fri Aug 15 2025;initiator methionine:1 for 49250 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BXS5 AP1M1 |
| _timestamp | 2025-08-15 22:06:06 |
| chain | initiator methionine:1 chain:2-423 |
| checksum | 64EC5E47EA6F8E98 |
| comment | FUNCTION Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.SUBUNIT Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCHF11 (By similarity). Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.SUBUNIT (Microbial infection) Interacts with HIV-1 Nef.INTERACTION Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.ALTERNATIVE PRODUCTS Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.SIMILARITY Belongs to the adaptor complexes medium subunit family. |
| description | recommendedName: AP-1 complex subunit mu-1 alternativeName: AP-mu chain family member mu1A alternativeName: Adaptor protein complex AP-1 subunit mu-1 alternativeName: Adaptor-related protein complex 1 subunit mu-1 alternativeName: Clathrin assembly protein complex 1 mu-1 medium chain 1 alternativeName: Clathrin coat assembly protein AP47 alternativeName: Clathrin coat-associated protein AP47 alternativeName: Golgi adaptor HA1/AP1 adaptin mu-1 subunit alternativeName: Mu-adaptin 1 alternativeName: Mu1A-adaptin |
| geneName | AP1M1 CLTNM |
| identifier | Q9BXS5 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cytoplasmic vesicle Direct protein sequencing Golgi apparatus Host-virus interaction Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | AP1M1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993461] ENSEMBL:ENSG00000072958 AP1M1 [Homo sapiens] |
| secondaryIdentifier | AP1M1_HUMAN Q4TTY5 |
| sequenceLength | 423 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964682] UniProt:Q9BXS5-1 AP1M1 [Homo sapiens] [ReferenceIsoform:8964683] UniProt:Q9BXS5-2 AP1M1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:167700] AP1M1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:350805] AP1M1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:351196] AP1M1 [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:432708] AP1M1 [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130512] AP1M1 [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:5334674] AP1M1 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799365] AP1M1 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806311] AP1M1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BXS5 AP1M1 (49250)
