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Details on Person UniProt:O43747 AP1G1

Class:IdReferenceGeneProduct:49246
_chainChangeLoginitiator methionine:1 added on Fri February 6 2015;chain:2-822 added on Fri February 6 2015
_displayNameUniProt:O43747 AP1G1
_timestamp2026-02-20 22:06:40
chainchain:1-822
checksum42EF40223DFBA5E9
commentFUNCTION Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).SUBUNIT Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3) (PubMed:34102099). Interacts (via GAE domain) with RABEP1 (PubMed:12042876, PubMed:12773381, PubMed:14665628). Interacts with SYNRG/gamma-synergin (PubMed:12042876). Interacts with EPS15 (By similarity). Interacts (via GAE domain) with AP1AR (via coiled-coil domain) (PubMed:15775984). Interacts with CLN3 (via dileucine motif); this interaction facilitates lysosomal targeting (PubMed:15598649). Interacts (via GAE domain) with AFTPH/aftiphilin; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell (PubMed:14665628, PubMed:15758025). Interacts with PSEN2; this interaction is dependent on PSEN2 phosphorylation and directs PSEN2 from early endosomes to late endosomes/lysosomes (PubMed:27293189).INTERACTION Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025).ALTERNATIVE PRODUCTS Widely expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the adaptor complexes large subunit family.
descriptionrecommendedName: fullName evidence="15"AP-1 complex subunit gamma-1 alternativeName: Adaptor protein complex AP-1 subunit gamma-1 alternativeName: Adaptor-related protein complex 1 subunit gamma-1 alternativeName: Clathrin assembly protein complex 1 gamma-1 large chain alternativeName: fullName evidence="14"Gamma-adaptin alternativeName: Gamma1-adaptin alternativeName: Golgi adaptor HA1/AP1 adaptin subunit gamma-1
geneNameAP1G1
ADTG
CLAPG1
identifierO43747
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Coated pit
Cytoplasm
Cytoplasmic vesicle
Disease variant
Golgi apparatus
Intellectual disability
Membrane
Protein transport
Proteomics identification
Reference proteome
Transport
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
nameAP1G1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8996416] ENSEMBL:ENSG00000166747 AP1G1 [Homo sapiens]
secondaryIdentifierAP1G1_HUMAN
O75709
O75842
Q9UG09
Q9Y3U4
sequenceLength822
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:8975003] UniProt:O43747-1 AP1G1 [Homo sapiens]
[ReferenceIsoform:8975004] UniProt:O43747-2 AP1G1 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:167703] AP1G1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:350808] AP1G1 [Golgi membrane] [Homo sapiens]
[EntityWithAccessionedSequence:351194] AP1G1 [cytoplasmic vesicle membrane] [Homo sapiens]
[EntityWithAccessionedSequence:432693] AP1G1 [lysosomal membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2130340] AP1G1 [trans-Golgi network membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5334660] AP1G1 [clathrin-coated endocytic vesicle membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O43747 AP1G1 (49246)
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