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Details on Person UniProt:P20848 SERPINA2
| Class:Id | ReferenceGeneProduct:49240 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;chain:22-420 added on Sat February 7 2015;chain:22-420 for 49240 removed on Mon August 15 2022;chain:22-421 for 49240 added on Mon August 15 2022 |
| _displayName | UniProt:P20848 SERPINA2 |
| _timestamp | 2024-11-03 20:04:12 |
| chain | signal peptide:1-21 chain:22-421 |
| checksum | 33A46EF9896FC91D |
| comment | FUNCTION Putative serine protease inhibitor.SUBUNIT Interacts with CANX and PDIA3.SUBCELLULAR LOCATION Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.DOMAIN The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).PTM Glycosylated.POLYMORPHISM The SERPINA2 gene is highly polymorphic. Deletions, frameshift mutations and a critical start codon variation (ATG->ATA, dbSNP:rs1956172) have been found in some populations. Population studies suggest that a pseudogenization process may be ongoing in humans (PubMed:17135331, PubMed:23826168, PubMed:9383284). 3 potentially functional alleles, V1, V2 and V3, have been described in the literature. The sequence shown in this entry is that of allele V2 (PubMed:23826168).SIMILARITY Belongs to the serpin family. |
| description | recommendedName: fullName evidence="7"Alpha-1-antitrypsin-related protein shortName evidence="6"AAT-related protein alternativeName: Protease inhibitor 1-like alternativeName: Serpin A2 |
| geneName | SERPINA2 ARGS ATR PIL SERPINA2P |
| identifier | P20848 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Glycoprotein Protease inhibitor Proteomics identification Reference proteome Serine protease inhibitor Signal |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SERPINA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9819395] ENSEMBL:ENSG00000274821 SERPINA2 [Homo sapiens] |
| secondaryIdentifier | A1ATR_HUMAN A0A0G2JPK4 S4UD68 |
| sequenceLength | 421 |
| species | [Species:48887] Homo sapiens |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P20848 SERPINA2 (49240)
