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Details on Person UniProt:Q13733 ATP1A4
| Class:Id | ReferenceGeneProduct:49226 |
|---|---|
| _chainChangeLog | chain:1-1029 added on Fri February 6 2015 |
| _displayName | UniProt:Q13733 ATP1A4 |
| _timestamp | 2025-05-21 21:35:10 |
| chain | chain:1-1029 |
| checksum | 69958248424D2C0B |
| comment | FUNCTION This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.CATALYTIC ACTIVITY K(+)(out) + Na(+)(in) + ATP + H2O = K(+)(in) + Na(+)(out) + ADP + phosphate + H(+)ACTIVITY REGULATION Specifically inhibited by an endogenous cardiac glycoside, ouabain.SUBUNIT The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.INTERACTION In mature sperm, located in the principle piece of the sperm flagellum.ALTERNATIVE PRODUCTS Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="8"Sodium/potassium-transporting ATPase subunit alpha-4 shortName: Na(+)/K(+) ATPase alpha-4 subunit ecNumber evidence="2"7.2.2.13 alternativeName: Sodium pump subunit alpha-4 |
| geneName | ATP1A4 ATP1AL2 |
| identifier | Q13733 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Ion transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Potassium Potassium transport Proteomics identification Reference proteome Sodium Sodium transport Sodium/potassium transport Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | ATP1A4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004546] ENSEMBL:ENSG00000132681 ATP1A4 [Homo sapiens] |
| secondaryIdentifier | AT1A4_HUMAN Q504T2 Q7Z4I9 Q8TBN8 Q8WXA7 Q8WXH7 Q8WY13 |
| sequenceLength | 1029 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143616] UniProt:Q13733-2 ATP1A4 [Homo sapiens] [ReferenceIsoform:405655] UniProt:Q13733-1 ATP1A4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:936914] ATP1A4 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13733 ATP1A4 (49226)
