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Details on Person UniProt:Q9Y2G3 ATP11B
| Class:Id | ReferenceGeneProduct:49216 |
|---|---|
| _chainChangeLog | chain:1-1177 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y2G3 ATP11B |
| _timestamp | 2026-02-20 22:52:08 |
| chain | chain:1-1177 |
| checksum | 665110145457B220 |
| comment | FUNCTION Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401).CATALYTIC ACTIVITY ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)COFACTOR The ATPase activity is up-regulated by aminophospholipids PS and PE.BIOPHYSICOCHEMICAL PROPERTIES Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11B and an accessory beta subunit TMEM30A.SUBCELLULAR LOCATION Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794).SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.SEQUENCE CAUTION Intron retention. |
| description | recommendedName: Phospholipid-transporting ATPase IF ecNumber evidence="8"7.6.2.1 alternativeName: ATPase IR alternativeName: ATPase class VI type 11B alternativeName: P4-ATPase flippase complex alpha subunit ATP11B |
| geneName | ATP11B ATPIF ATPIR KIAA0956 |
| identifier | Q9Y2G3 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Endoplasmic reticulum Endosome Golgi apparatus Lipid transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ATP11B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991140] ENSEMBL:ENSG00000058063 ATP11B [Homo sapiens] |
| secondaryIdentifier | AT11B_HUMAN Q96FN1 Q9UKK7 |
| sequenceLength | 1177 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:939755] ATP11B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6798770] ATP11B [azurophil granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y2G3 ATP11B (49216)
