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Details on Person UniProt:Q9P241 ATP10D
| Class:Id | ReferenceGeneProduct:49212 |
|---|---|
| _chainChangeLog | chain:1-1426 added on Sat February 7 2015 |
| _displayName | UniProt:Q9P241 ATP10D |
| _timestamp | 2025-02-21 19:04:27 |
| chain | chain:1-1426 |
| checksum | 97EE929F81AC59AE |
| comment | FUNCTION Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane.CATALYTIC ACTIVITY ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.CATALYTIC ACTIVITY a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)COFACTOR Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP10A and an accessory beta subunit TMEM30A.SUBCELLULAR LOCATION Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.ALTERNATIVE PRODUCTS Expressed in placenta and, to a lesser extent, in kidney.PTM Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. |
| description | recommendedName: Phospholipid-transporting ATPase VD ecNumber evidence="13"7.6.2.1 alternativeName: ATPase class V type 10D alternativeName: P4-ATPase flippase complex alpha subunit ATP10D |
| geneName | ATP10D ATPVD KIAA1487 |
| identifier | Q9P241 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Cell membrane Endoplasmic reticulum Lipid transport Magnesium Membrane Metal-binding Nucleotide-binding Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ATP10D |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002213] ENSEMBL:ENSG00000145246 ATP10D [Homo sapiens] |
| secondaryIdentifier | AT10D_HUMAN A2RRC8 D6REN2 Q8NC70 Q96SR3 |
| sequenceLength | 1426 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143608] UniProt:Q9P241-2 ATP10D [Homo sapiens] [ReferenceIsoform:415017] UniProt:Q9P241-1 ATP10D [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:939764] ATP10D [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9P241 ATP10D (49212)
