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Details on Person UniProt:O60312 ATP10A

Class:Id	ReferenceGeneProduct:49210
_chainChangeLog	chain:1-1499 added on Fri February 6 2015
_displayName	UniProt:O60312 ATP10A
_timestamp	2025-02-21 19:04:26
chain	chain:1-1499
checksum	D4996A4D0635A68D
comment	FUNCTION Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:25947375, PubMed:29599178). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492).CATALYTIC ACTIVITY ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)CATALYTIC ACTIVITY a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)COFACTOR Inhibited under hypotonic conditions.SUBUNIT Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP10A and an accessory beta subunit TMEM30A.INTERACTION Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.ALTERNATIVE PRODUCTS Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.PTM Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
description	recommendedName: Phospholipid-transporting ATPase VA ecNumber evidence="10 12"7.6.2.1 alternativeName: ATPase class V type 10A alternativeName: Aminophospholipid translocase VA alternativeName: P4-ATPase flippase complex alpha subunit ATP10A
geneName	ATP10A ATP10C ATPVA ATPVC KIAA0566
identifier	O60312
isSequenceChanged	FALSE
keyword	Alternative splicing ATP-binding Cell membrane Endoplasmic reticulum Lipid transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ATP10A
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8998173] ENSEMBL:ENSG00000206190 ATP10A [Homo sapiens]
secondaryIdentifier	AT10A_HUMAN Q4G0S9 Q969I4
sequenceLength	1499
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8970391] UniProt:O60312-1 ATP10A [Homo sapiens] [ReferenceIsoform:8970392] UniProt:O60312-2 ATP10A [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:939756] ATP10A [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O60312 ATP10A (49210)