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Details on Person UniProt:O94823 ATP10B
| Class:Id | ReferenceGeneProduct:49208 |
|---|---|
| _chainChangeLog | chain:1-1461 added on Fri February 6 2015 |
| _displayName | UniProt:O94823 ATP10B |
| _timestamp | 2025-02-21 19:04:26 |
| chain | chain:1-1461 |
| checksum | 2676B90416B6B541 |
| comment | FUNCTION Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons.CATALYTIC ACTIVITY ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.CATALYTIC ACTIVITY a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)COFACTOR Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP10B and an accessory beta subunit TMEM30A.INTERACTION Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.ALTERNATIVE PRODUCTS Expressed in predominantly in brain structures including medulla oblongata, substantia nigra and basal ganglia. Expressed in the gastrointestinal system with highest levels in the small intestine and colon. Also expressed at low levels in testis and thymus.PTM Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. |
| description | recommendedName: Phospholipid-transporting ATPase VB ecNumber evidence="9"7.6.2.1 alternativeName: ATPase class V type 10B alternativeName: P4-ATPase flippase complex alpha subunit ATP10B |
| geneName | ATP10B ATPVB KIAA0715 |
| identifier | O94823 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Endoplasmic reticulum Endosome Lipid transport Lysosome Magnesium Membrane Metal-binding Nucleotide-binding Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ATP10B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989383] ENSEMBL:ENSG00000118322 ATP10B [Homo sapiens] |
| secondaryIdentifier | AT10B_HUMAN Q9H725 |
| sequenceLength | 1461 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143606] UniProt:O94823-2 ATP10B [Homo sapiens] [ReferenceIsoform:143607] UniProt:O94823-3 ATP10B [Homo sapiens] [ReferenceIsoform:402053] UniProt:O94823-1 ATP10B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:939740] ATP10B [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O94823 ATP10B (49208)
