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Details on Person UniProt:P05408 SCG5
| Class:Id | ReferenceGeneProduct:49202 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Sat February 7 2015;chain:27-212 added on Sat February 7 2015;chain:27-176 added on Sat February 7 2015;peptide:200-212 added on Sat February 7 2015 |
| _displayName | UniProt:P05408 SCG5 |
| _timestamp | 2024-11-03 20:13:01 |
| chain | signal peptide:1-26 chain:27-212 chain:27-176 peptide:200-212 |
| checksum | A459702055C0FE84 |
| comment | FUNCTION Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.SUBUNIT Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.INTERACTION Neuroendocrine and endocrine secretory granules.ALTERNATIVE PRODUCTS Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.PTM Sulfated on tyrosine residues.SIMILARITY Belongs to the 7B2 family. |
| description | recommendedName: Neuroendocrine protein 7B2 alternativeName: Pituitary polypeptide alternativeName: Secretogranin V alternativeName: Secretogranin-5 alternativeName: Secretory granule endocrine protein I component recommendedName: N-terminal peptide /component component recommendedName: C-terminal peptide /component |
| geneName | SCG5 SGNE1 |
| identifier | P05408 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chaperone Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neuropeptide Phosphoprotein Proteomics identification Reference proteome Secreted Signal Sulfation Transport |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SCG5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991103] ENSEMBL:ENSG00000166922 SCG5 [Homo sapiens] |
| secondaryIdentifier | 7B2_HUMAN P01164 Q6FHD0 Q9BS38 |
| sequenceLength | 212 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143603] UniProt:P05408-2 SCG5 [Homo sapiens] [ReferenceIsoform:402442] UniProt:P05408-1 SCG5 [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P05408 SCG5 (49202)
