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Details on Person UniProt:P28221 HTR1D
| Class:Id | ReferenceGeneProduct:49168 |
|---|---|
| _chainChangeLog | chain:1-377 added on Fri February 6 2015 |
| _displayName | UniProt:P28221 HTR1D |
| _timestamp | 2024-11-03 20:08:39 |
| chain | chain:1-377 |
| checksum | 0A4FCF81FFE2322A |
| comment | FUNCTION G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968). May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968). May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968).SUBUNIT Homodimer. Heterodimer with HTR1B.SUBCELLULAR LOCATION Detected in brain neocortex and caudate nucleus (at protein level).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: fullName evidence="11"5-hydroxytryptamine receptor 1D shortName evidence="11"5-HT-1D shortName evidence="11"5-HT1D alternativeName: fullName evidence="11"Serotonin 1D alpha receptor shortName evidence="11"5-HT-1D-alpha alternativeName: fullName evidence="11"Serotonin receptor 1D |
| geneName | HTR1D HTR1DA HTRL |
| identifier | P28221 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HTR1D |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996389] ENSEMBL:ENSG00000179546 HTR1D [Homo sapiens] |
| secondaryIdentifier | 5HT1D_HUMAN |
| sequenceLength | 377 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:390940] HTR1D [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P28221 HTR1D (49168)
