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Details on Person UniProt:P08195 SLC3A2

Class:Id	ReferenceGeneProduct:49162
_chainChangeLog	chain:1-630 added on Fri February 6 2015;initiator methionine: for 49162 added on Sun February 16 2020;initiator methionine: for 49162 removed on Fri Aug 15 2025;initiator methionine:1 for 49162 added on Fri Aug 15 2025;chain:1-630 for 49162 removed on Fri Feb 20 2026;chain:2-529 for 49162 added on Fri Feb 20 2026
_displayName	UniProt:P08195 SLC3A2
_timestamp	2026-05-15 20:42:39
chain	initiator methionine:1 chain:2-529
checksum	82F26856737E8F31
comment	FUNCTION Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115).FUNCTION (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.FUNCTION (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells.SUBUNIT Disulfide-linked heterodimer with a non-glycosylated catalytic light subunit (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 or SLC7A11) (PubMed:10574970, PubMed:10903140, PubMed:11311135, PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:35352032, PubMed:9751058, PubMed:9829974). Interacts with TLCD3A/CT120 (PubMed:12270127). Interacts with ICAM1 (PubMed:12716892). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 (PubMed:11696247). Interacts with LAPTM4B; recruits SLC3A2 and SLC7A5/LAT1 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).SUBUNIT (Microbial infection) Interacts with hepatitis C virus/HCV envelope glycoprotein E2; the interaction may facilitate viral entry into host cell.INTERACTION Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:11311135, PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity).ALTERNATIVE PRODUCTS Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.INDUCTION Expression is induced in resting peripheral blood T-lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Up-regulated in response to hydrogen peroxide (PubMed:30341327). Highly expressed in various cancer types (PubMed:19292886, PubMed:23116296, PubMed:28350098).INDUCTION (Microbial infection) Up-regulated upon hepatitis C virus/HCV infection via NS3-A4 viral protein complex; the up-regulation is mediated by oxidative stress (PubMed:30341327). Up-regulation of the complex formed by SLC3A2 and SLC7A5/LAT1 upon hepatitis C virus/HCV infection (PubMed:30341327).PTM N-glycosylated; N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane.PTM Phosphorylation on Ser-305; Ser-307 or Ser-309 and on Ser-426 or Ser-430 by ecto-protein kinases favors heterotypic cell-cell interactions.MASS SPECTROMETRY Belongs to the SLC3A transporter family.
description	recommendedName: fullName evidence="59"Amino acid transporter heavy chain SLC3A2 alternativeName: fullName evidence="57"4F2 cell-surface antigen heavy chain shortName evidence="54"4F2hc alternativeName: fullName evidence="56"4F2 heavy chain antigen alternativeName: fullName evidence="58"Lymphocyte activation antigen 4F2 large subunit alternativeName: fullName evidence="55"Solute carrier family 3 member 2 cdAntigenNameCD98/cdAntigenName
geneName	SLC3A2 MDU1
identifier	P08195
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Amino-acid transport Cell junction Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Host cell receptor for virus entry Isopeptide bond Lysosome Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal-anchor Transmembrane Transmembrane helix Transport Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15
name	SLC3A2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002176] ENSEMBL:ENSG00000168003 SLC3A2 [Homo sapiens]
secondaryIdentifier	4F2_HUMAN J3KPF3 Q13543
sequenceLength	529
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:436187] UniProt:P08195-1 SLC3A2 [Homo sapiens] [ReferenceIsoform:436188] UniProt:P08195-2 SLC3A2 [Homo sapiens] [ReferenceIsoform:436189] UniProt:P08195-3 SLC3A2 [Homo sapiens] [ReferenceIsoform:9834301] UniProt:P08195-5 SLC3A2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:352179] SLC3A2 [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P08195 SLC3A2 (49162)