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Details on Person UniProt:P63104 YWHAZ

Class:Id	ReferenceGeneProduct:48917
_chainChangeLog	chain:1-245 added on Sat February 7 2015
_displayName	UniProt:P63104 YWHAZ
_timestamp	2026-02-20 21:46:21
chain	chain:1-245
checksum	D464DF2286BBFE60
comment	FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).SUBUNIT Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer (PubMed:12865427, PubMed:16376338). Heterodimerizes with YWHAE (PubMed:16376338). Homo- and heterodimerization is inhibited by phosphorylation on Ser-58 (PubMed:16376338). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232 (PubMed:31024343). Interacts with BRAF (PubMed:31024343). Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (PubMed:19640509). Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (PubMed:16959763). Interacts with MEFV (PubMed:27030597). Interacts with ADAM22 (via C-terminus) (PubMed:12589811).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus protein BPLF1 and TRIM25; leading to inhibition of the type-I IFN response.INTERACTION Located to stage I to stage IV melanosomes.ALTERNATIVE PRODUCTS The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (PubMed:15071501, PubMed:15696159). Phosphorylation on Thr-232; inhibits binding of RAF1 (PubMed:9360956). Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338). Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the 14-3-3 family.CAUTION Was originally thought to have phospholipase A2 activity.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
description	recommendedName: 14-3-3 protein zeta/delta alternativeName: Protein kinase C inhibitor protein 1 shortName: KCIP-1
geneName	YWHAZ
identifier	P63104
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Host-virus interaction Intellectual disability Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	YWHAZ
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958381] ENSEMBL:ENSG00000164924 YWHAZ [Homo sapiens]
secondaryIdentifier	1433Z_HUMAN A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33
sequenceLength	245
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8966404] UniProt:P63104-1 YWHAZ [Homo sapiens] [ReferenceIsoform:8966405] UniProt:P63104-2 YWHAZ [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:206099] YWHAZ [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:450469] YWHAZ [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2457868] YWHAZ [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:8958135] YWHAZ [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P63104 YWHAZ (48917)