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Details on Person UniProt:P62260 Ywhae
| Class:Id | ReferenceGeneProduct:48897 |
|---|---|
| _chainChangeLog | chain:1-255 added on Fri February 6 2015 |
| _displayName | UniProt:P62260 Ywhae |
| _timestamp | 2025-08-15 20:57:44 |
| chain | chain:1-255 |
| checksum | 07817CCBD1F75B26 |
| comment | FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.SUBUNIT Homodimer (By similarity). Heterodimerizes with YWHAZ (By similarity). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with ARHGEF28 (By similarity). Interacts with BEX3 (By similarity). Weakly interacts with CDKN1B (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with DENND1A (By similarity). Interacts with GAB2 (By similarity). Interacts with phosphorylated GRB10 (By similarity). Interacts with KSR1 (By similarity). Interacts with NDEL1 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with the phosphorylated (by AKT1) form of SRPK2 (By similarity). Interacts with TIAM2 (By similarity). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts with ZFP36 (via phosphorylated form) (By similarity). Interacts with SLITRK1 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner (By similarity). Interacts with RIPOR2 (By similarity). Interacts with KLHL22; required for the nuclear localization of KLHL22 upon amino acid starvation (By similarity). Interacts with CRTC1 (By similarity). Interacts with CRTC2 (probably when phosphorylated at 'Ser-171') (By similarity). Interacts with CRTC3 (probably when phosphorylated at 'Ser-162' and/or 'Ser-273') (By similarity). Interacts with ATP2B1 and ATP2B3; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with MEFV (By similarity). Interacts with RNF115 (By similarity). Interacts with GPR15; this interaction promotes ER-to-Golgi transport of GPR15 (By similarity).INTERACTION Present at high levels in the pineal gland early in development and decreased steadily thereafter.SIMILARITY Belongs to the 14-3-3 family. |
| description | recommendedName: 14-3-3 protein epsilon shortName: 14-3-3E alternativeName: Mitochondrial import stimulation factor L subunit shortName: MSF L |
| geneName | Ywhae |
| identifier | P62260 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Ywhae |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | 1433E_RAT P29360 P42655 Q63631 |
| sequenceLength | 255 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62260 Ywhae (48897)
