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Details on Person UniProt:P62259 Ywhae
| Class:Id | ReferenceGeneProduct:48894 |
|---|---|
| _chainChangeLog | chain:1-255 added on Sat February 7 2015 |
| _displayName | UniProt:P62259 Ywhae |
| _timestamp | 2025-08-15 21:12:39 |
| chain | chain:1-255 |
| checksum | 07817CCBD1F75B26 |
| comment | FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.SUBUNIT Homodimer (By similarity). Heterodimerizes with YWHAZ (By similarity). Interacts with PKA-phosphorylated AANAT (By similarity). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with ARHGEF28 (PubMed:11533041). Interacts with BEX3 (PubMed:11278287). Weakly interacts with CDKN1B (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with DENND1A (By similarity). Interacts with GAB2 (By similarity). Interacts with phosphorylated GRB10 (PubMed:15722337). Interacts with KSR1 (PubMed:10409742). Interacts with NDEL1 (PubMed:12796778). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with the phosphorylated (by AKT1) form of SRPK2 (By similarity). Interacts with TIAM2 (PubMed:17320046). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (PubMed:21078877). Interacts with SLITRK1 (By similarity). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner (By similarity). Interacts with RIPOR2 (By similarity). Interacts with KLHL22; required for the nuclear localization of KLHL22 upon amino acid starvation (By similarity). Interacts with CRTC1 (PubMed:30611118). Interacts with CRTC2 (probably when phosphorylated at 'Ser-171') (PubMed:30611118). Interacts with CRTC3 (probably when phosphorylated at 'Ser-162' and/or 'Ser-273') (PubMed:30611118). Interacts with ATP2B1 and ATP2B3; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with MEFV (By similarity). Interacts with RNF115 (By similarity). Interacts with GPR15; this interaction promotes ER-to-Golgi transport of GPR15 (By similarity).INTERACTION In the 8.5 dpc embryo, expressed throughout the embryo. Within a day, expression was more marked in mesenchyme than elsewhere (e.g. epithelial tissue, where it was generally low), although levels in neural tissue rose again by about 12.5 dpc. This difference was maintained until 15.5 dpc when expression levels started to drop in most tissues, with those of the nervous system, tooth, and kidney being exceptions. Strongly expressed in early mesenchyme. The expression decreased as the mesenchyme differentiated.DISRUPTION PHENOTYPE Knockouts show reduced viability with reduced growth and a shortened skull (PubMed:30973865). Mutants show increased thresholds across all frequencies associated with variable amounts of accumulated fluid and exudate containing inflammatory cells in the middle ear, suggesting predisposition to otitis media. The middle ear mucosa appear thickened with granulation tissue in sections and the luminal surface show an open Eustachian tube but abundant clusters of goblet cells with fewer ciliated epithelial cells (PubMed:30973865).SIMILARITY Belongs to the 14-3-3 family. |
| description | recommendedName: 14-3-3 protein epsilon shortName: 14-3-3E |
| geneName | Ywhae |
| identifier | P62259 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Ywhae |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | 1433E_MOUSE P29360 P42655 Q63631 |
| sequenceLength | 255 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1445119] 14-3-3 epsilon [cytosol] [Mus musculus] [EntityWithAccessionedSequence:2457852] 14-3-3 epsilon [cytoplasmic vesicle membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P62259 Ywhae (48894)
