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Details on Person UniProt:P31946 YWHAB

Class:Id	ReferenceGeneProduct:48889
_chainChangeLog	initiator methionine:1 added on Sat February 7 2015;chain:1-246 added on Sat February 7 2015;chain:2-246 added on Sat February 7 2015;initiator methionine:1 for 48889 removed on Fri Nov 03 2023;initiator methionine: for 48889 added on Fri Nov 03 2023;initiator methionine: for 48889 removed on Fri Aug 15 2025;initiator methionine:1 for 48889 added on Fri Aug 15 2025
_displayName	UniProt:P31946 YWHAB
_timestamp	2025-08-15 21:12:37
chain	chain:1-246 initiator methionine:1 chain:2-246
checksum	6BE1A9BF97468017
comment	FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.SUBUNIT Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15159416, PubMed:15454081). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844). Interacts with MARK2 and MARK3 (PubMed:16959763). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (PubMed:11555644). Interacts with MEFV (PubMed:27030597). Interacts with HDAC4 (PubMed:33537682). Interacts with ADAM22 (via C-terminus) (PubMed:15882968).SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.SUBUNIT (Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SUBCELLULAR LOCATION (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.ALTERNATIVE PRODUCTS The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.SIMILARITY Belongs to the 14-3-3 family.
description	recommendedName: 14-3-3 protein beta/alpha alternativeName: Protein 1054 alternativeName: Protein kinase C inhibitor protein 1 shortName: KCIP-1 component recommendedName: 14-3-3 protein beta/alpha, N-terminally processed /component
geneName	YWHAB
identifier	P31946
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative initiation Cytoplasm Direct protein sequencing Host-virus interaction Isopeptide bond Membrane Nitration Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Vacuole
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	YWHAB
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8957452] ENSEMBL:ENSG00000166913 YWHAB [Homo sapiens]
secondaryIdentifier	1433B_HUMAN A8K9K2 E1P616
sequenceLength	246
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:217387] UniProt:P31946-2 YWHAB [Homo sapiens] [ReferenceIsoform:403657] UniProt:P31946-1 YWHAB [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:48888] YWHAB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:190058] YWHAB [endosome] [Homo sapiens] [EntityWithAccessionedSequence:2457861] YWHAB [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:8958427] YWHAB [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P31946 YWHAB (48889)