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Details on Person AXIN mutants destabilize the destruction complex

Class:Id	FailedReaction:4839734
_displayName	AXIN mutants destabilize the destruction complex
_doRelease	TRUE
_timestamp	2014-12-11 18:42:29
authored	[InstanceEdit:4839725] Rothfels, K, 2013-11-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839736] Rothfels, K, 2013-11-02
disease	[Disease:1500689] cancer [Disease:2327993] hepatocellular carcinoma
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:4839737] decreased_transcript_level and loss_of_function of truncation and missense AXIN mutants [cytosol]
input	[CandidateSet:4839738] truncation and missense AXIN mutants [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1504189] AMER1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:195263] CSNK1A1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2997551] GSK3B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5246690] K63polyUb-APC [cytosol] [Homo sapiens] [Complex:196206] PP2A [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5251535] The links between axin and carcinogenesis [LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5251487] Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding [LiteratureReference:5251479] Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability
modified	[InstanceEdit:5246703] Rothfels, K, 2014-01-22 [InstanceEdit:5251576] Rothfels, K, 2014-02-04 [InstanceEdit:5358779] Rothfels, Karen, 2014-04-03 [InstanceEdit:5433121] Rothfels, Karen, 2014-05-12 [InstanceEdit:5545631] Rothfels, Karen, 2014-05-22 [InstanceEdit:5656319] Rothfels, Karen, 2014-12-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AXIN mutants destabilize the destruction complex
normalReaction	[Reaction:195251] Assembly of the destruction complex [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645152] R-HSA-4839734.2
summation	[Summation:5251523] Alterations in AXIN1 have been detected in a number of diffe...
(hasEvent)	[Pathway:5467340] AXIN missense mutants destabilize the destruction complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785273] Update Tracker - [FailedReaction:4839734] AXIN mutants destabilize the destruction complex - v52:[add_removeInput]
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