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Details on Person CTNNB1 S33 mutants aren't phosphorylated by GSK3beta

Class:IdFailedReaction:4839634
_displayNameCTNNB1 S33 mutants aren't phosphorylated by GSK3beta
_doReleaseTRUE
_timestamp2015-09-01 13:56:00
authored[InstanceEdit:4837328] Rothfels, K, 2013-10-30
compartment[Compartment:70101] cytosol
created[InstanceEdit:4839633] Rothfels, K, 2013-11-01
disease[Disease:1500689] cancer
edited[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus[EntityFunctionalStatus:5339709] loss_of_function of pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
input[SimpleEntity:113592] ATP [cytosol]
[Complex:4839632] pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:5255496] Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies
[LiteratureReference:5255458] beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer
[LiteratureReference:5246618] Wnt signaling and cancer
[LiteratureReference:5251531] Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
modified[InstanceEdit:5246702] Rothfels, K, 2014-01-22
[InstanceEdit:5255523] Rothfels, K, 2014-02-06
[InstanceEdit:5339730] Rothfels, K, 2014-03-07
[InstanceEdit:5358781] Rothfels, Karen, 2014-04-03
[InstanceEdit:5433123] Rothfels, Karen, 2014-05-12
[InstanceEdit:5545636] Rothfels, Karen, 2014-05-22
[InstanceEdit:6793383] Rothfels, Karen, 2015-09-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCTNNB1 S33 mutants aren't phosphorylated by GSK3beta
normalReaction
releaseDate2014-06-10
reviewed[InstanceEdit:5433076] Salahshor, S, 2014-05-12
[InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644535] R-HSA-4839634.3
summation[Summation:5255475] S33 mutations of beta-catenin interfere with GSK3 phosphoryl...
(hasEvent)[Pathway:5358747] CTNNB1 S33 mutants aren't phosphorylated [Homo sapiens]
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