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Details on Person (d)NDP + ATP <=> (d)NTP + ADP (NME4)

Class:IdReaction:482804
_displayName(d)NDP + ATP <=> (d)NTP + ADP (NME4)
_doReleaseTRUE
_timestamp2025-12-09 20:34:40
authored[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
catalystActivity[CatalystActivity:110637] nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane]
catalystActivityReference[CatalystActivityReference:9643657] nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane] The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
compartment[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:482809] D'Eustachio, P, 2010-01-28
crossReference[DatabaseIdentifier:9976216] RHEA:27687
[DatabaseIdentifier:9976215] RHEA:25238
[DatabaseIdentifier:9976235] RHEA:25099
[DatabaseIdentifier:9976225] RHEA:27675
[DatabaseIdentifier:9976218] RHEA:27691
[DatabaseIdentifier:9976212] RHEA:27679
[DatabaseIdentifier:9976222] RHEA:27683
[DatabaseIdentifier:9976213] RHEA:28583
edited[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
input[DefinedSet:482803] (d)NDP [mitochondrial matrix]
[SimpleEntity:113593] ATP [mitochondrial matrix]
isChimericFALSE
literatureReference[LiteratureReference:110641] The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
[LiteratureReference:110592] Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis
[LiteratureReference:482797] The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration
modified[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:525790] D'Eustachio, P, 2010-02-22
[InstanceEdit:532680] D'Eustachio, P, 2010-03-02
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8847953] Jassal, Bijay, 2015-12-03
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09
name(d)NDP + ATP <=> (d)NTP + ADP (NME4)
GDP + ATP => GTP + ADP
CDP + ATP => CTP + ADP
UDP + ATP => UTP + ADP
dADP + ATP => dATP + ADP
dGDP + ATP => dGTP + ADP
dCDP + ATP => dCTP + ADP
dTDP + ATP => dTTP + ADP
dUDP + ATP => dUTP + ADP
output[DefinedSet:482807] (d)NTP [mitochondrial matrix]
[SimpleEntity:113581] ADP [mitochondrial matrix]
releaseDate2010-03-16
reverseReaction
reviewed[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105759] R-HSA-482804.6
summation[Summation:482810] Nucleoside diphosphate kinase NME4 associated with the inner...
(hasEvent)[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(replacementInstances)[_Deleted:482808] Deletion of instances: 110734, 110722, 110710, 110695, 110682, 110670, 110657, 110654, 110639
[_Deleted:482811] Deletion of instance: 110640
[_Deleted:482815] Deletion of instance: 110580
(reverseReaction)[Reaction:482812] (d)NTP + ADP <=> (d)NDP + ATP (NME4) [Homo sapiens]
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