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Details on Person (d)NDP + ATP <=> (d)NTP + ADP (NME4)
Class:Id Reaction:482804
_displayName (d)NDP + ATP <=> (d)NTP + ADP (NME4)
_doRelease TRUE
_timestamp 2025-12-09 20:34:40
authored [InstanceEdit:504064] D'Eustachio, P, 2010-02-05
catalystActivity [CatalystActivity:110637] nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane]
catalystActivityReference [CatalystActivityReference:9643657] nucleoside diphosphate kinase activity of NME4 hexamer [mitochondrial inner membrane] The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
compartment [Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created [InstanceEdit:482809] D'Eustachio, P, 2010-01-28
crossReference [DatabaseIdentifier:9976216] RHEA:27687 [DatabaseIdentifier:9976215] RHEA:25238 [DatabaseIdentifier:9976235] RHEA:25099 [DatabaseIdentifier:9976225] RHEA:27675 [DatabaseIdentifier:9976218] RHEA:27691 [DatabaseIdentifier:9976212] RHEA:27679 [DatabaseIdentifier:9976222] RHEA:27683 [DatabaseIdentifier:9976213] RHEA:28583
edited [InstanceEdit:504064] D'Eustachio, P, 2010-02-05
input [DefinedSet:482803] (d)NDP [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix]
isChimeric FALSE
literatureReference [LiteratureReference:110641] The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase [LiteratureReference:110592] Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis [LiteratureReference:482797] The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration
modified [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:525790] D'Eustachio, P, 2010-02-22 [InstanceEdit:532680] D'Eustachio, P, 2010-03-02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8847953] Jassal, Bijay, 2015-12-03 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09
name (d)NDP + ATP <=> (d)NTP + ADP (NME4) GDP + ATP => GTP + ADP CDP + ATP => CTP + ADP UDP + ATP => UTP + ADP dADP + ATP => dATP + ADP dGDP + ATP => dGTP + ADP dCDP + ATP => dCTP + ADP dTDP + ATP => dTTP + ADP dUDP + ATP => dUTP + ADP
output [DefinedSet:482807] (d)NTP [mitochondrial matrix] [SimpleEntity:113581] ADP [mitochondrial matrix]
releaseDate 2010-03-16
reverseReaction
reviewed [InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1105759] R-HSA-482804.6
summation [Summation:482810] Nucleoside diphosphate kinase NME4 associated with the inner...
(hasEvent) [Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(replacementInstances) [_Deleted:482808] Deletion of instances: 110734, 110722, 110710, 110695, 110682, 110670, 110657, 110654, 110639 [_Deleted:482811] Deletion of instance: 110640 [_Deleted:482815] Deletion of instance: 110580
(reverseReaction) [Reaction:482812] (d)NTP + ADP <=> (d)NDP + ATP (NME4) [Homo sapiens]
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