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Details on Person WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)

Class:IdReaction:4827383
_displayNameWHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)
_doReleaseTRUE
_timestamp2015-09-04 20:28:03
authored[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity[CatalystActivity:4827374] histone H3 methyltransferase activity of WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4827380] Jupe, S, 2013-10-29
edited[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
input[CandidateSet:4657030] Histone H3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:3301907] The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate
[LiteratureReference:5173306] NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
[LiteratureReference:5638155] Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
[LiteratureReference:5638166] The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
modified[InstanceEdit:5084131] Jupe, S, 2013-11-08
[InstanceEdit:5159248] Jupe, S, 2013-11-22
[InstanceEdit:5173339] Jupe, S, 2013-11-27
[InstanceEdit:5627270] Jupe, Steve, 2014-10-17
[InstanceEdit:5632358] Jassal, Bijay, 2014-10-28
[InstanceEdit:5633086] Jassal, Bijay, 2014-10-30
[InstanceEdit:5634799] Jupe, Steve, 2014-11-06
[InstanceEdit:5637656] Jupe, Steve, 2014-11-12
[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
[InstanceEdit:5638320] Jupe, Steve, 2014-11-13
[InstanceEdit:5643672] Jupe, Steve, 2014-11-17
[InstanceEdit:5643684] Jupe, Steve, 2014-11-17
[InstanceEdit:5674563] Jupe, Steve, 2015-02-13
[InstanceEdit:5676065] Jupe, Steve, 2015-02-19
[InstanceEdit:6787649] Jupe, Steve, 2015-07-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameWHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)
WHSC1, NSD1, SMYD2 methylate lysine-37 of histone H3
output[CandidateSet:5638139] MeK37-histone H3 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate2015-03-15
reviewed[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6781665] R-HSA-4827383.3
summation[Summation:4827377] Methylation of histone H3 lysine-37 (H3K36) is tightly assoc...
systematicNameWHSC1, NSD1, SMYD2 transfer CH3 from AdoMet to histone H3
(hasEvent)[Pathway:3214841] PKMTs methylate histone lysines [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784893] Update Tracker - [Reaction:4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - v52:[modifyText]
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No pathways have been reviewed or authored by WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (4827383)
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