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Details on Person Methylation of histone H3 lysine-37 (H3K36) is tightly assoc...

Class:IdSummation:4827377
_displayNameMethylation of histone H3 lysine-37 (H3K36) is tightly assoc...
_timestamp2015-02-12 15:56:24
created[InstanceEdit:4827380] Jupe, S, 2013-10-29
literatureReference[LiteratureReference:5638145] Understanding the language of Lys36 methylation at histone H3
[LiteratureReference:3301907] The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate
[LiteratureReference:5173306] NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
[LiteratureReference:5638155] Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
[LiteratureReference:5638166] The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
modified[InstanceEdit:5173302] Jupe, S, 2013-11-26
[InstanceEdit:5634718] Jupe, Steve, 2014-11-05
[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
[InstanceEdit:5669201] Jupe, Steve, 2015-01-30
[InstanceEdit:5674398] Jupe, Steve, 2015-02-12
textMethylation of histone H3 lysine-37 (H3K36) is tightly associated with actively transcribed genes and appears to correspond primarily with coding regions (Wagner & Carpenter 2011).

WHSC1 (KMT3G, NSD2, MMSET), a member of the SET2 family, dimethylates H3K36 when provided with nucleosome substrates (Li et al 2009; Qiao et al. 2011). Dimethylation of histone H3 at lysine-37 (H3K36me2) is thought to be the principal chromatin-regulatory activity of WHSC1 (Kuo et al. 2011), SMYD2 (KMT3C) (Brown et al 2006) and NSD1 (KMT3B) (Li et al. 2009, Qiao et al. 2011).
(summation)[Reaction:4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) [Homo sapiens]
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