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Details on Person The Goosecoid (GSC) gene is transcribed to yield mRNA and th...
| Class:Id | Summation:480773 |
|---|---|
| _displayName | The Goosecoid (GSC) gene is transcribed to yield mRNA and th... |
| _timestamp | 2022-07-25 09:36:42 |
| created | [InstanceEdit:480249] May, B, 2010-01-27 |
| literatureReference | [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells |
| modified | [InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:3656308] May, B, 2013-06-03 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 [InstanceEdit:9760369] May, Bruce, 2021-12-16 [InstanceEdit:9760419] May, Bruce, 2021-12-18 [InstanceEdit:9766345] May, Bruce, 2022-02-19 [InstanceEdit:9773633] May, Bruce, 2022-05-08 [InstanceEdit:9794984] May, Bruce, 2022-07-25 [InstanceEdit:9795001] May, Bruce, 2022-07-25 |
| text | The Goosecoid (GSC) gene is transcribed to yield mRNA and the mRNA is translated to yield GSC protein. Expression of GSC is first observed in the region of the epiblast where the primitive streak forms (inferred from the mouse homolog). Expression then becomes restricted to the anterior primitive streak and the anterior midline mesoderm. Phosphorylated SMAD2 and SMAD3 in complexes with SMAD4 and TRIM33 activate transcription of GSC (inferred from mouse homologs). Beta-catenin (CTNNB1) also binds the GSC promoter and interacts with SMAD2 and SMAD3 to enhance transcription of GSC (Funa et al. 2015). GSC can bind its own promoter and downregulate expression (Danilov et al. 1998). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the GSC gene (Boyer et al. 2005), OCT4 and SOX2 repress transcription of GSC, and NANOG activates transcription of GSC in human embryonic stem cells (Babaie et al. 2007, Teo et al. 2011). |
| (summation) | [BlackBoxEvent:480378] Expression of Goosecoid (GSC) in the primitive streak [Homo sapiens] |
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No pathways have been reviewed or authored by The Goosecoid (GSC) gene is transcribed to yield mRNA and th... (480773)
