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Details on Person Reprogramming towards pluripotency requires AID-dependent DNA demethylation
| Class:Id | LiteratureReference:480746 |
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| _displayName | Reprogramming towards pluripotency requires AID-dependent DNA demethylation |
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| _timestamp | 2013-11-12 20:27:46 |
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| author | [Person:480220] Bhutani, N
[Person:480156] Brady, JJ
[Person:480372] Damian, M
[Person:480239] Sacco, A
[Person:480598] Corbel, SY
[Person:480495] Blau, Helen M |
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| created | [InstanceEdit:480249] May, B, 2010-01-27 |
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| journal | Nature |
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| modified | [InstanceEdit:480941] May, B, 2010-01-27
[InstanceEdit:5099820] D'Eustachio, P, 2013-11-12 |
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| pages | 1042-1047 |
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| pubMedIdentifier | 20027182 |
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| title | Reprogramming towards pluripotency requires AID-dependent DNA demethylation |
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| volume | 463 |
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| year | 2009 |
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| (literatureReference) | [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) [Homo sapiens]
[Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens]
[BlackBoxEvent:452838] Expression of NANOG [Homo sapiens]
[Reaction:480140] Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA [Homo sapiens]
[RegulationReference:9641771] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells
[RegulationReference:9642305] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis
[CatalystActivityReference:9644052] cytidine deaminase activity of AICDA [nucleoplasm] Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming |
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