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Details on Person Activation-induced cytidine deaminase (AID/AICDA) deaminates...
| Class:Id | Summation:480557 |
|---|---|
| _displayName | Activation-induced cytidine deaminase (AID/AICDA) deaminates... |
| _timestamp | 2010-12-01 13:01:24 |
| created | [InstanceEdit:480249] May, B, 2010-01-27 |
| modified | [InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:1014235] May, B, 2010-11-13 [InstanceEdit:1101836] May, B, 2010-12-01 |
| text | Activation-induced cytidine deaminase (AID/AICDA) deaminates cytosine in DNA to yield uracil (Ramiro et al. 2003, Dickerson et al. 2003, Sohail et al. 2003). The non-template strand in transcribed DNA is the preferred substrate. AID also deaminates 5-methylcytosine (5-mC) in DNA to yield thymine (Morgan et al. 2004, Bhutani et al. 2009). When the reaction occurs on double-stranded DNA a 5-mC:G basepair is converted to a T:G mismatch. The thymine is believed to be repaired to cytosine, effectively demethylating the original 5-methylcytosine (Bhutani et al. 2009). |
| (summation) | [Reaction:480140] Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA [Homo sapiens] |
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No pathways have been reviewed or authored by Activation-induced cytidine deaminase (AID/AICDA) deaminates... (480557)
