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Details on Person Expression of FGF2

Class:Id	BlackBoxEvent:480515
_displayName	Expression of FGF2
_doRelease	TRUE
_timestamp	2018-10-31 13:57:27
authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:480249] May, B, 2010-01-27
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[EntityWithAccessionedSequence:2888971] FGF2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:480565] Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines [LiteratureReference:480743] Expression of fetal kidney growth factors in a kidney tumor line: role of FGF2 in kidney development [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:1101810] Immunolocalization of fibroblast growth factor receptor 1 and its ligands in human tissues [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal [LiteratureReference:5251069] Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells [LiteratureReference:5251082] A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
modified	[InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:561173] May, B, 2010-03-30 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2901807] May, B, 2013-01-03 [InstanceEdit:2972981] D'Eustachio, P, 2013-01-06 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5250254] May, B, 2014-01-24 [InstanceEdit:5250255] May, B, 2014-01-24 [InstanceEdit:5251098] May, B, 2014-01-31 [InstanceEdit:5638458] May, Bruce, 2014-11-15 [InstanceEdit:6800126] May, Bruce, 2015-09-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626992] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of FGF2
output	[EntityWithAccessionedSequence:189898] FGF2(143-288) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:2972960] POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter [Homo sapiens] [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] [BlackBoxEvent:452894] Expression of SOX2 [Homo sapiens] [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:5638457] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642288] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]' Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines
releaseDate	2014-03-12
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644451] R-HSA-480515.6
summation	[Summation:480384] The FGF2 (bFGF) gene is transcribed to yield mRNA and the mR...
(hasEvent)	[Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens] [Pathway:2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation [Homo sapiens]
(precedingEvent)	[Reaction:190245] FGFR1b binds to FGF [Homo sapiens] [Reaction:190256] FGFR1c binds to FGF [Homo sapiens] [Reaction:190261] FGFR3c binds to FGF [Homo sapiens] [Reaction:190265] FGFR4 binds to FGF [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783819] Update Tracker - [BlackBoxEvent:480515] Expression of FGF2 - v55:[removeCatalystActivity] [_UpdateTracker:9785916] Update Tracker - [BlackBoxEvent:480515] Expression of FGF2 - v51:[addCatalystActivity, addRegulator, add_removeInput]
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No pathways have been reviewed or authored by Expression of FGF2 (480515)