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Details on Person KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter...
| Class:Id | Summation:480303 |
|---|---|
| _displayName | KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter... |
| _timestamp | 2014-01-23 02:07:13 |
| created | [InstanceEdit:480249] May, B, 2010-01-27 |
| modified | [InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:1014235] May, B, 2010-11-13 [InstanceEdit:2975872] May, B, 2013-01-09 [InstanceEdit:2975874] May, B, 2013-01-09 [InstanceEdit:3656308] May, B, 2013-06-03 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 [InstanceEdit:5244494] May, B, 2014-01-18 [InstanceEdit:5246733] May, B, 2014-01-23 |
| text | KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the NANOG gene and enhance expression of NANOG (Rodda et al. 2005, Boyer et al. 2005, Babaie et al. 2007, Jin et al. 2007, Chan et al. 2009, Vallier et al. 2009, Jung et al. 2011). In mouse Nanog has been shown to repress its own expression (Fidalgo et al. 2012, Navarro et al. 2012). ZIC3, a NANOG target, also positively regulates NANOG expression, possibly by binding the NANOG promoter and activating transcription (Lim et al. 2007). Activin/Nodal signaling regulates NANOG via SMAD2 and SMAD3 (Brown et al. 2011) |
| (summation) | [Reaction:480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter [Homo sapiens] |
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No pathways have been reviewed or authored by KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter... (480303)
