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Details on Person Expression of EPAS1 (HIF2A)

Class:Id	BlackBoxEvent:480301
_displayName	Expression of EPAS1 (HIF2A)
_doRelease	TRUE
_timestamp	2018-11-20 03:44:18
authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:480249] May, B, 2010-01-27
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[EntityWithAccessionedSequence:2888960] EPAS1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:1101833] Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
modified	[InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2892244] May, B, 2012-12-31 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5246709] May, B, 2014-01-22 [InstanceEdit:5638458] May, Bruce, 2014-11-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626991] May, Bruce, 2018-10-31 [InstanceEdit:9629283] May, Bruce, 2018-11-20 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of EPAS1 (HIF2A)
output	[EntityWithAccessionedSequence:452560] EPAS1 [nucleoplasm] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:480943] Positive gene expression regulation by 'HIF3A [nucleoplasm]'
regulationReference	[RegulationReference:9641358] Positive gene expression regulation by 'HIF3A [nucleoplasm]' Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
releaseDate	2014-03-12
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644539] R-HSA-480301.7
summation	[Summation:480385] The EPAS1 (HIF2A) gene is transcribed to yield mRNA and the ... [Summation:480857] Hypoxia causes an increase in the level of HIF3A which in tu...
(hasEvent)	[Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens] [Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1234161] HIF-alpha translocates from cytosol to nucleus [Homo sapiens] [Reaction:1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) [Homo sapiens] [Reaction:1234166] Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) [Homo sapiens] [Reaction:1234179] Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775841] Update Tracker - [BlackBoxEvent:480301] Expression of EPAS1 (HIF2A) - v78:[addSummation] [_UpdateTracker:9778673] Update Tracker - [BlackBoxEvent:480301] Expression of EPAS1 (HIF2A) - v68:[removeCatalystActivity] [_UpdateTracker:9785652] Update Tracker - [BlackBoxEvent:480301] Expression of EPAS1 (HIF2A) - v51:[addCatalystActivity]
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No pathways have been reviewed or authored by Expression of EPAS1 (HIF2A) (480301)