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Details on Person POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter
Class:Id Reaction:480204 _displayName POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter _doRelease TRUE _timestamp 2016-09-18 08:54:56 authored [InstanceEdit:1013049] May, B, 2010-11-12 compartment [Compartment:7660] nucleoplasm created [InstanceEdit:480249] May, B, 2010-01-27 edited [InstanceEdit:1013049] May, B, 2010-11-12 input [EntityWithAccessionedSequence:434463] KLF4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452586] NANOG [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452472] POU5F1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:453045] PBX1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452271] SOX2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2888972] NANOG gene [nucleoplasm] [Homo sapiens] [Complex:206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8939362] FOXP1-ES [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:480780] KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:1112612] A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells [LiteratureReference:1112605] Zic3 is required for maintenance of pluripotency in embryonic stem cells [LiteratureReference:2888933] OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells [LiteratureReference:452445] Transcriptional regulation of nanog by OCT4 and SOX2 [LiteratureReference:3270568] Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells [LiteratureReference:5244461] Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming [LiteratureReference:5246714] Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches modified [InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1014235] May, B, 2010-11-13 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1112614] May, B, 2010-12-06 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2895780] May, B, 2013-01-03 [InstanceEdit:2975872] May, B, 2013-01-09 [InstanceEdit:2975874] May, B, 2013-01-09 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:3270572] May, B, 2013-04-11 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 [InstanceEdit:5244494] May, B, 2014-01-18 [InstanceEdit:5246709] May, B, 2014-01-22 [InstanceEdit:5246733] May, B, 2014-01-23 [InstanceEdit:5251384] May, B, 2014-02-03 [InstanceEdit:8939408] May, Bruce, 2016-09-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter output [Complex:480463] POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2014-03-12 reviewed [InstanceEdit:5246708] Wang, Jianlong, 2014-01-22 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:5644575] R-HSA-480204.3 summation [Summation:480303] KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter... (hasEvent) [Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens] (precedingEvent) [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] (updatedInstance) [_UpdateTracker:9782304] Update Tracker - [Reaction:480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter - v59:[addInput]
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