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Details on Person Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA

Class:Id	Reaction:480140
_displayName	Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA
_doRelease	FALSE
_timestamp	2016-07-15 23:50:17
authored	[InstanceEdit:1013049] May, B, 2010-11-12
catalystActivity	[CatalystActivity:480290] cytidine deaminase activity of AICDA [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644052] cytidine deaminase activity of AICDA [nucleoplasm] Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:480249] May, B, 2010-01-27
edited	[InstanceEdit:1013049] May, B, 2010-11-12
input	[OtherEntity:212172] DNA containing 5-mC [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:480670] Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming [LiteratureReference:480746] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [LiteratureReference:1014229] Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand [LiteratureReference:1014239] AID mediates hypermutation by deaminating single stranded DNA [LiteratureReference:1014230] Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
modified	[InstanceEdit:480941] May, B, 2010-01-27 [InstanceEdit:500370] May, B, 2010-02-03 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1014235] May, B, 2010-11-13 [InstanceEdit:1086965] May, B, 2010-11-29 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9643047] Wu, G, 2019-04-04
name	Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA
output	[GenomeEncodedEntity:110149] (T:G)-dsDNA [nucleoplasm] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8916249] R-HSA-480140.1
summation	[Summation:480557] Activation-induced cytidine deaminase (AID/AICDA) deaminates...
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No pathways have been reviewed or authored by Activation-induced Cytidine Deaminase (AID/AICDA) Converts 5-methylcytidine to Thymine in DNA (480140)