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Details on Person SRD5A1 dehydrogenates TEST to DHTEST

Class:Id	Reaction:469659
_displayName	SRD5A1 dehydrogenates TEST to DHTEST
_doRelease	TRUE
_timestamp	2020-10-29 12:03:23
authored	[InstanceEdit:469658] Jassal, B, 2010-01-25
catalystActivity	[CatalystActivity:469661] 3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:469658] Jassal, B, 2010-01-25
edited	[InstanceEdit:469658] Jassal, B, 2010-01-25
input	[SimpleEntity:193057] TEST [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:469665] Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases [LiteratureReference:1434477] A critical review of the origin and control of adrenal androgens
modified	[InstanceEdit:469670] Jassal, B, 2010-01-25 [InstanceEdit:555951] D'Eustachio, P, 2010-03-22 [InstanceEdit:737645] D'Eustachio, P, 2010-05-13 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1502543] Jassal, B, 2011-08-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9705709] Jassal, Bijay, 2020-10-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRD5A1 dehydrogenates TEST to DHTEST Testosterone is converted to 5-alpha-dihydroxytestosterone
output	[SimpleEntity:469662] DHTEST [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:193064] HSD17B3-like proteins reducde ANDST to TEST [Homo sapiens] [Reaction:193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST [Homo sapiens] [Reaction:193099] CYP17A1 cleaves 17aHPROG to ANDST [Homo sapiens]
regulatedBy	[PositiveRegulation:1449720] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105798] R-HSA-469659.4
summation	[Summation:469660] The conversion of testosterone to the most potent androgen, ...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:9705925] Androgens binds AR (in the HSP90 chaperone complex) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776568] Update Tracker - [Reaction:469659] SRD5A1 dehydrogenates TEST to DHTEST - v75:[modifyText, removeLiteratureReference] [_UpdateTracker:9789433] Update Tracker - [Reaction:469659] SRD5A1 dehydrogenates TEST to DHTEST - v38:[addLiteratureReference, addRegulator, modifyText]
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