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Details on Person NuRD complex [nucleoplasm]

Class:Id	Complex:4657018
_displayName	NuRD complex [nucleoplasm]
_timestamp	2015-09-04 18:39:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4657017] Jupe, S, 2013-10-04
hasComponent	[Complex:4657004] HDAC1:HDAC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205021] HDAC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205135] HDAC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212223] RBBP4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:212227] RBBP7 [nucleoplasm] [Homo sapiens] [DefinedSet:4657021] Mi-2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4657010] MBD3 [nucleoplasm] [Homo sapiens] [DefinedSet:4657019] MTA1, MTA2, MTA3 [nucleoplasm] [Homo sapiens] [CandidateSet:4657014] (GATAD2A, GATAD2B) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3730996] The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities [LiteratureReference:4657001] Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
modified	[InstanceEdit:4657022] Jupe, S, 2013-10-04 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:6787649] Jupe, Steve, 2015-07-15
name	NuRD complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5648720] R-HSA-4657018.2
(activeUnit)	[NegativeGeneExpressionRegulation:9844533] Negative gene expression regulation by 'NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9844551] Negative gene expression regulation by 'NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm]' [NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]'
(hasComponent)	[Complex:427352] TTFI:Sal Box:CSB:G9a:NuRD [nucleoplasm] [Homo sapiens] [Complex:5250633] rDNA promoter:UBTF:ERCC6:NuRD [nucleoplasm] [Homo sapiens] [Complex:8943778] SALL4:NuRD [nucleoplasm] [Homo sapiens] [Complex:9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] [Homo sapiens] [Complex:9842855] NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] [Homo sapiens] [Complex:9844534] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] [Homo sapiens] [Complex:9844535] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] [Homo sapiens] [Complex:9844537] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] [Homo sapiens] [Complex:9844538] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] [Homo sapiens] [Complex:9976373] GATA3:CHD4:NuRD:TBX21 gene [nucleoplasm] [Homo sapiens]
(hasMember)	[DefinedSet:4657020] HDAC1:2-containing complex [nucleoplasm] [Homo sapiens]
(input)	[Reaction:427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene [Homo sapiens] [Reaction:8943780] SALL4 recruits NuRD to PTEN gene [Homo sapiens] [Reaction:9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex [Homo sapiens] [Reaction:9842876] NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement [Homo sapiens] [Reaction:9844438] ZNF423 recruits NuRD to EBF2 target genes [Homo sapiens] [Reaction:9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene [Homo sapiens]
(output)	[Reaction:5250632] ERCC6 recruits KAT2B and RNA Pol I to rRNA promoter [Homo sapiens]
(regulator)	[NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9889096] Update Tracker - [Complex:4657018] NuRD complex [nucleoplasm] - v48:[addLiteratureReference]
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No pathways have been reviewed or authored by NuRD complex [nucleoplasm] (4657018)