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Details on Person CBX4 (Pc2) SUMOylates CBS with SUMO1

Class:Id	Reaction:4655432
_displayName	CBX4 (Pc2) SUMOylates CBS with SUMO1
_timestamp	2019-04-08 08:22:21
authored	[InstanceEdit:4641368] May, B, 2013-09-28
catalystActivity	[CatalystActivity:3108185] SUMO transferase activity of PRC1 complex [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644136] SUMO transferase activity of PRC1 complex [nucleoplasm] The polycomb protein Pc2 is a SUMO E3
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4655376] May, B, 2013-10-03
edited	[InstanceEdit:4641368] May, B, 2013-09-28
input	[Complex:4655337] CBS tetramer [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4655434] Human cystathionine beta-synthase is a target for sumoylation [LiteratureReference:4655430] Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9644137] May, Bruce, 2019-04-08
name	CBX4 (Pc2) SUMOylates CBS with SUMO1
output	[Complex:4655369] SUMO1:CBS tetramer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8922341] R-HSA-4655432.1
summation	[Summation:4655417] CBX4 (Pc2) SUMOylates CBS at lysine-211 with SUMO1. SUMOylat...
(hasEvent)	[Pathway:3108232] SUMO E3 ligases SUMOylate target proteins [Homo sapiens]
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No pathways have been reviewed or authored by CBX4 (Pc2) SUMOylates CBS with SUMO1 (4655432)