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Details on Person Transcriptional activation of CDKN1A by TP53 is inhibited by EP400

Class:Id	BlackBoxEvent:4647613
_displayName	Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
_doRelease	TRUE
_timestamp	2014-11-20 02:34:01
authored	[InstanceEdit:187964] Matthews, L, 2006-09-29 13:54:26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4647614] Orlic-Milacic, M, 2013-09-30
edited	[InstanceEdit:188346] Matthews, L, 2006-10-10 08:05:07
input	[EntityWithAccessionedSequence:3786256] CDKN1A gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression. [LiteratureReference:4647608] The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
modified	[InstanceEdit:5093950] Orlic-Milacic, M, 2013-11-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
output	[EntityWithAccessionedSequence:182585] CDKN1A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:3786258] TP53 binds the CDKN1A promoter [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:4647593] EP400 binds CDKN1A promoter [Homo sapiens] [Reaction:3786258] TP53 binds the CDKN1A promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:4647597] Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:4647606] Positive gene expression regulation by 'p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642410] Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
releaseDate	2013-12-04
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:4647612] Orlic-Milacic, M, 2013-09-30
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644321] R-HSA-4647613.4
summation	[Summation:4647602] CDKN1A (p21) is transcriptionally activated by TP53 (p53) af...
(hasEvent)	[Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens]
(precedingEvent)	[Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 [Homo sapiens] [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Homo sapiens]
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