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Details on Person SUMOylation of TOP1 with SUMO1

Class:IdReaction:4641362
_displayNameSUMOylation of TOP1 with SUMO1
_doReleaseTRUE
_timestamp2022-01-19 16:49:50
authored[InstanceEdit:4616035] May, B, 2013-09-27
catalystActivity[CatalystActivity:2997650] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9644118] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] Identification of a substrate recognition site on Ubc9
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4641299] May, B, 2013-09-28
edited[InstanceEdit:4616035] May, B, 2013-09-27
goBiologicalProcess[GO_BiologicalProcess:4162] protein sumoylation
input[EntityWithAccessionedSequence:4641363] TOP1 [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4641304] SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
[LiteratureReference:4641300] Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein
[LiteratureReference:4641312] Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin
[LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli
modified[InstanceEdit:4663810] May, B, 2013-10-06
[InstanceEdit:5626908] May, Bruce, 2014-10-13
[InstanceEdit:6803018] May, Bruce, 2015-10-04
[InstanceEdit:9644119] May, Bruce, 2019-04-08
[InstanceEdit:9762281] May, Bruce, 2022-01-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSUMOylation of TOP1 with SUMO1
output[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4641364] monoSUMO1-K117-TOP1 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:6803017] Zhang, Xiang-Dong, 2015-10-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812340] R-HSA-4641362.4
summation[Summation:4641317] TOP1 is SUMOylated at lysine-117 with SUMO1 (Mao et al. 2000...
(hasEvent)[Pathway:4615885] SUMOylation of DNA replication proteins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775103] Update Tracker - [Reaction:4641362] SUMOylation of TOP1 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by SUMOylation of TOP1 with SUMO1 (4641362)
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