Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person SUMOylation of TOP2A with SUMO1

Class:IdReaction:4641342
_displayNameSUMOylation of TOP2A with SUMO1
_doReleaseTRUE
_timestamp2022-01-19 16:49:56
authored[InstanceEdit:4616035] May, B, 2013-09-27
catalystActivity[CatalystActivity:2997650] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9644118] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] Identification of a substrate recognition site on Ubc9
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4641299] May, B, 2013-09-28
edited[InstanceEdit:4616035] May, B, 2013-09-27
goBiologicalProcess[GO_BiologicalProcess:4162] protein sumoylation
input[EntityWithAccessionedSequence:1362276] TOP2A [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4641313] SUMO-1 conjugation to human DNA topoisomerase II isozymes
[LiteratureReference:4641337] Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha
[LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli
[LiteratureReference:5678239] Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition
modified[InstanceEdit:4663810] May, B, 2013-10-06
[InstanceEdit:5626908] May, Bruce, 2014-10-13
[InstanceEdit:5678245] May, Bruce, 2015-02-23
[InstanceEdit:6803018] May, Bruce, 2015-10-04
[InstanceEdit:9644119] May, Bruce, 2019-04-08
[InstanceEdit:9762281] May, Bruce, 2022-01-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSUMOylation of TOP2A with SUMO1
output[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4641367] monoSUMO1-K-TOP2A [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:6803017] Zhang, Xiang-Dong, 2015-10-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812337] R-HSA-4641342.4
summation[Summation:4641308] TOP2A is SUMOylated with SUMO1 (Mao et al. 2000, Dawlaty et ...
(hasEvent)[Pathway:4615885] SUMOylation of DNA replication proteins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775231] Update Tracker - [Reaction:4641342] SUMOylation of TOP2A with SUMO1 - v80:[add_removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by SUMOylation of TOP2A with SUMO1 (4641342)