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Details on Person Defective RFT1 does not flip the N-glycan precursor

Class:IdFailedReaction:4570573
_displayNameDefective RFT1 does not flip the N-glycan precursor
_doReleaseTRUE
_timestamp2024-05-16 13:59:30
authored[InstanceEdit:4570574] Jassal, B, 2013-09-23
catalystActivity[CatalystActivity:9631742] glycolipid floppase activity of RFT1 R67C [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
created[InstanceEdit:4570574] Jassal, B, 2013-09-23
disease[Disease:3781892] congenital disorder of glycosylation type I
edited[InstanceEdit:4570574] Jassal, B, 2013-09-23
entityFunctionalStatus[EntityFunctionalStatus:4570579] loss_of_function of RFT1 R67C [endoplasmic reticulum membrane]
input[SimpleEntity:449332] (GlcNAc)2 (Man)5 (PP-Dol)1 [cytoplasmic side of endoplasmic reticulum membrane]
isChimericFALSE
literatureReference[LiteratureReference:449289] Human RFT1 deficiency leads to a disorder of N-linked glycosylation
[LiteratureReference:449763] Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein
modified[InstanceEdit:5083143] Jassal, B, 2013-11-05
[InstanceEdit:5615515] Jassal, Bijay, 2014-07-24
[InstanceEdit:5627272] Jassal, Bijay, 2014-10-17
[InstanceEdit:5632708] Matthews, Lisa, 2014-10-28
[InstanceEdit:5633234] Jassal, Bijay, 2014-10-31
[InstanceEdit:5635755] Matthews, Lisa, 2014-11-07
[InstanceEdit:5671966] Jassal, Bijay, 2015-02-03
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9910684] D'Eustachio, Peter, 2024-05-16
nameDefective RFT1 does not flip the N-glycan precursor
normalReaction
releaseDate2014-12-11
reviewed[InstanceEdit:5633220] Belaya, Katsiaryna, 2014-10-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5622809] R-HSA-4570573.4
summation[Summation:4570564] The N-glycan precursor is flipped across the ER membrane, mo...
systematicNameRFT1 R67C does not translocate (GlcNAc)2 (Man)5 (PP-Dol)1 from integral component of cytoplasmic side of endoplasmic reticulum membrane to integral component of lumenal side of endoplasmic reticulum membrane
(hasEvent)[Pathway:4570571] Defective RFT1 causes CDG-1n [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778348] Update Tracker - [FailedReaction:4570573] Defective RFT1 does not flip the N-glycan precursor - v68:[addCatalystActivity]
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