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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Cholesterol biosynthesis

Class:IdPathwayDiagram:456958
_displayNameDiagram of Cholesterol biosynthesis
_timestamp2025-11-11 00:31:37
created[InstanceEdit:456957] Jassal, B, 2010-01-22
height2523
modified[InstanceEdit:469693] Jassal, B, 2010-01-25
[InstanceEdit:478860] Jassal, B, 2010-01-26
[InstanceEdit:478869] Jassal, B, 2010-01-26
[InstanceEdit:481015] Jassal, B, 2010-01-27
[InstanceEdit:481025] Jassal, B, 2010-01-27
[InstanceEdit:555077] D'Eustachio, P, 2010-03-22
[InstanceEdit:1097341] Matthews, L, 2010-11-30
[InstanceEdit:2603292] D'Eustachio, P, 2012-11-19
[InstanceEdit:3015812] Jassal, B, 2013-02-05
[InstanceEdit:5212701] Jassal, B, 2013-12-13
[InstanceEdit:5212703] Jassal, B, 2013-12-13
[InstanceEdit:5324616] Jassal, B, 2014-02-17
[InstanceEdit:5671876] Jassal, Bijay, 2015-02-03
[InstanceEdit:6807046] D'Eustachio, Peter, 2015-10-28
[InstanceEdit:8848221] Jassal, Bijay, 2015-12-07
[InstanceEdit:8848224] Jassal, Bijay, 2015-12-07
[InstanceEdit:8952136] Jupe, Steve, 2016-12-13
[InstanceEdit:8956435] Jupe, Steve, 2017-01-23
[InstanceEdit:8963883] Jassal, Bijay, 2017-02-13
[InstanceEdit:9705611] Jassal, Bijay, 2020-10-27
[InstanceEdit:9717837] Jassal, Bijay, 2021-03-15
[InstanceEdit:9717978] Jassal, Bijay, 2021-03-16
[InstanceEdit:9735739] D'Eustachio, Peter, 2021-06-30
[InstanceEdit:9755936] Jassal, Bijay, 2021-10-11
[InstanceEdit:9756524] Jassal, Bijay, 2021-10-15
[InstanceEdit:9756547] Jassal, Bijay, 2021-10-15
[InstanceEdit:9756757] Jassal, Bijay, 2021-10-18
[InstanceEdit:9758609] Stephan, Ralf, 2021-11-19
[InstanceEdit:9758610] Stephan, Ralf, 2021-11-19
[InstanceEdit:9758611] Stephan, Ralf, 2021-11-19
[InstanceEdit:9758612] Stephan, Ralf, 2021-11-19
[InstanceEdit:9758613] Stephan, Ralf, 2021-11-19
[InstanceEdit:9758614] Stephan, Ralf, 2021-11-19
[InstanceEdit:9767888] Matthews, Lisa, 2022-03-02
[InstanceEdit:9768037] D'Eustachio, Peter, 2022-03-03
[InstanceEdit:9768137] Matthews, Lisa, 2022-03-03
[InstanceEdit:9768168] Matthews, Lisa, 2022-03-04
[InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10
[InstanceEdit:9945230] D'Eustachio, Peter, 2025-04-11
[InstanceEdit:9945797] D'Eustachio, Peter, 2025-04-18
[InstanceEdit:9945825] D'Eustachio, Peter, 2025-04-18
[InstanceEdit:9946139] D'Eustachio, Peter, 2025-04-21
[InstanceEdit:9947147] D'Eustachio, Peter, 2025-05-01
[InstanceEdit:9947156] D'Eustachio, Peter, 2025-05-01
[InstanceEdit:9947210] D'Eustachio, Peter, 2025-05-02
[InstanceEdit:9947452] D'Eustachio, Peter, 2025-05-05
[InstanceEdit:9949606] D'Eustachio, Peter, 2025-05-22
[InstanceEdit:9949607] D'Eustachio, Peter, 2025-05-22
[InstanceEdit:9968596] D'Eustachio, Peter, 2025-10-16
[InstanceEdit:9969571] D'Eustachio, Peter, 2025-10-22
[InstanceEdit:9969620] D'Eustachio, Peter, 2025-10-23
[InstanceEdit:9971702] D'Eustachio, Peter, 2025-11-10
[InstanceEdit:9971762] Matthews, Lisa, 2025-11-11
representedPathway[Pathway:191273] Cholesterol biosynthesis [Homo sapiens]
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textPosition="736 1289" /> <org.gk.render.RenderableProtein id="2441" reactomeId="3006223" position="851 1014" bounds="819 1003 64 23" textPosition="819 1003" /> <org.gk.render.RenderableProtein id="2443" reactomeId="194707" position="846 1213" bounds="822 1202 48 23" textPosition="822 1202"> <Properties> <displayName>NSDHL</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2459" reactomeId="29356" position="749 665" bounds="728 650 43 31" textPosition="732 654" /> <org.gk.render.RenderableProtein id="2461" reactomeId="194648" position="840 767" bounds="814 756 52 23" textPosition="814 756" /> <org.gk.render.RenderableComplex id="2463" reactomeId="8957351" position="825 725" bounds="780 714 90 23" textPosition="780 715" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="2465" reactomeId="8957354" position="822 805" bounds="777 794 90 23" textPosition="777 795" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="2469" reactomeId="29368" position="749 840" bounds="732 825 34 31" textPosition="736 829"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2471" reactomeId="70106" position="749 892" bounds="731 877 36 31" textPosition="735 881" /> <org.gk.render.RenderableChemical id="2475" reactomeId="29356" position="1376 106" bounds="1355 91 43 31" textPosition="1359 95" /> <org.gk.render.RenderableComplex id="2483" reactomeId="8957351" position="1305 202" bounds="1275 184 60 37" textPosition="1276 185" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CYP450:Fe3+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2485" reactomeId="8957354" position="1196 204" bounds="1164 187 64 34" textPosition="1167 185" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="2486" reactomeId="29370" position="543 851" bounds="523 836 41 31" textPosition="527 840"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> </Nodes> <Edges> <org.gk.render.RenderableReaction id="20" reactomeId="191405" points="533 1187, 533 1593, 533 1614" position="533 1593" lineWidth="1.0"> <Inputs> <Input id="28" stoichiometry="2" /> </Inputs> <Outputs> <Output id="59" points="502 1634" /> <Output id="105" points="549 1619" /> </Outputs> <Catalysts> <Catalyst id="29" points="795 1716, 700 1709, 668 1595" /> </Catalysts> <Properties> <displayName>Two FAPP molecules dimerize to form presqualene diphosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="191380" points="483 532, 483 552, 484 580" position="483 552" lineWidth="1.0"> <Inputs> <Input id="58" points="483 519" /> <Input id="48" points="520 519" /> </Inputs> <Outputs> <Output id="19" points="484 606" /> <Output id="56" points="520 588" /> <Output id="2227" points="446 591" /> </Outputs> <Catalysts> <Catalyst id="18" points="447 552" /> </Catalysts> <Properties> <displayName>Mevalonate is phosphorylated to mevalonate-5-phosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="26" reactomeId="191422" points="484 664, 485 689, 485 712" position="485 689" lineWidth="1.0"> <Inputs> <Input id="19" points="484 643" /> <Input id="92" points="520 652" /> </Inputs> <Outputs> <Output id="37" points="486 744" /> <Output id="88" points="520 723" /> </Outputs> <Catalysts> <Catalyst id="60" points="417 691" /> </Catalysts> <Properties> <displayName>Mevalonate-5-phosphate is further phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="27" reactomeId="191366" points="542 1956, 712 2233, 927 2232, 964 2176" position="927 2232" lineWidth="1.0"> <Inputs> <Input id="22" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Catalysts> <Catalyst id="21" points="926 2180" /> </Catalysts> <Properties> <displayName>Squalene 2,3-epoxide cyclizes, forming lanosterol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="191352" points="482 389, 482 421, 482 448" position="482 421" lineWidth="1.0"> <Inputs> <Input id="32" points="482 357" /> <Input id="45" stoichiometry="2" points="522 379" /> <Input id="40" stoichiometry="2" points="455 383" /> </Inputs> <Outputs> <Output id="49" stoichiometry="2" points="448 466" /> <Output id="58" points="482 482" /> <Output id="1471" points="509 456" /> </Outputs> <Catalysts> <Catalyst id="16" points="782 418" /> </Catalysts> <Properties> <displayName>HMGCR dimer reduces bHMG-CoA to MVA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="191414" points="487 802, 488 821, 485 893" position="488 821" lineWidth="1.0"> <Inputs> <Input id="90" points="520 795" /> <Input id="37" points="487 781" /> </Inputs> <Outputs> <Output id="52" points="527 902" /> <Output id="99" points="482 965" /> <Output id="2486" points="520 865" /> </Outputs> <Catalysts> <Catalyst id="54" points="434 818" /> </Catalysts> <Properties> <displayName>MVD decarboxylates MVA5PP to IPPP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="191322" points="376 1024, 375 1053, 375 1099" position="375 1053" lineWidth="1.0"> <Inputs> <Input id="33" points="376 1002" /> <Input id="99" points="459 990" /> </Inputs> <Outputs> <Output id="23" points="414 1066" /> <Output id="102" points="418 1133" /> </Outputs> <Catalysts> <Catalyst id="1728" points="334 1062" /> </Catalysts> <Properties> <displayName>FDPS dimer transfers IPPP to DMAPP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="42" reactomeId="191382" points="459 982, 438 982, 409 982" position="438 982" lineWidth="1.0"> <Inputs> <Input id="99" /> </Inputs> <Outputs> <Output id="33" /> </Outputs> <Catalysts> <Catalyst id="34" points="438 945" /> </Catalysts> <Properties> <displayName>Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="191323" points="479 217, 480 246, 481 292" position="480 246" lineWidth="1.0"> <Inputs> <Input id="31" points="444 205" /> <Input id="2135" points="505 211" /> <Input id="1475" points="479 187" /> </Inputs> <Outputs> <Output id="51" points="371 308" /> <Output id="32" points="482 320" /> <Output id="2137" points="508 299" /> </Outputs> <Catalysts> <Catalyst id="36" points="448 246" /> </Catalysts> <Properties> <displayName>HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="46" reactomeId="191299" points="533 1839, 533 1861, 533 1878" position="533 1861" lineWidth="1.0"> <Inputs> <Input id="63" points="533 1809" /> <Input id="47" points="567 1806" /> <Input id="72" points="516 1833" /> <Input id="74" points="592 1834" /> </Inputs> <Outputs> <Output id="22" points="533 1919" /> <Output id="70" points="595 1922" /> <Output id="82" points="485 1917" /> </Outputs> <Catalysts> <Catalyst id="25" points="800 1761, 708 1770, 669 1861" /> </Catalysts> <Properties> <displayName>Squalene is oxidized to its epoxide</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="191402" points="533 1706, 533 1731, 533 1756" position="533 1731" lineWidth="1.0"> <Inputs> <Input id="59" points="496 1671" /> <Input id="76" points="506 1702" /> <Input id="78" points="555 1686" /> </Inputs> <Outputs> <Output id="50" points="494 1748" /> <Output id="63" points="533 1772" /> <Output id="80" points="474 1777" /> </Outputs> <Catalysts> <Catalyst id="29" points="795 1720, 587 1731" /> </Catalysts> <Properties> <displayName>Reduction of presqualene diphosphate to form squalene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="191303" points="481 1028, 481 1083, 482 1122" position="481 1083" lineWidth="1.0"> <Inputs> <Input id="23" points="460 1040" /> <Input id="99" points="481 1002" /> </Inputs> <Outputs> <Output id="28" points="515 1150" /> <Output id="102" points="458 1136" /> </Outputs> <Catalysts> <Catalyst id="1728" points="350 1077" /> </Catalysts> <Properties> <displayName>FDPS dimer transfers IPPP to GPP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="194678" points="1070 2211, 1100 2211, 1136 2211" position="1100 2211" lineWidth="1.0"> <Inputs> <Input id="64" points="997 2168" /> <Input id="114" stoichiometry="3" points="1043 2286" /> <Input id="117" stoichiometry="3" points="1076 2254" /> <Input id="121" stoichiometry="3" points="1031 2245" /> </Inputs> <Outputs> <Output id="109" stoichiometry="4" points="1223 2249" /> <Output id="110" points="1219 2216" /> <Output id="111" points="1277 2167" /> <Output id="119" stoichiometry="3" points="1169 2250" /> </Outputs> <Catalysts> <Catalyst id="112" points="1100 2176" /> </Catalysts> <Properties> <displayName>CYP51A1 demethylates LAN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="194674" points="1335 2377, 1359 2377, 1388 2377" position="1359 2377" lineWidth="1.0"> <Inputs> <Input id="124" points="1311 2354" /> <Input id="125" points="1320 2393" /> <Input id="126" points="1277 2378" /> </Inputs> <Outputs> <Output id="127" points="1426 2377" /> <Output id="128" points="1405 2356" /> </Outputs> <Catalysts> <Catalyst id="129" points="1357 2450" /> </Catalysts> <Properties> <displayName>4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="194698" points="1422 2212, 1444 2212, 1465 2212" position="1444 2212" lineWidth="1.0"> <Inputs> <Input id="111" points="1351 2173" /> <Input id="135" points="1380 2238" /> <Input id="137" points="1423 2238" /> </Inputs> <Outputs> <Output id="132" points="1518 2183" /> <Output id="139" points="1498 2238" /> </Outputs> <Catalysts> <Catalyst id="133" points="1444 2178" /> </Catalysts> <Properties> <displayName>4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="194641" points="1678 2205, 1719 2207, 1761 2207" position="1719 2207" lineWidth="1.0"> <Inputs> <Input id="132" points="1592 2177" /> <Input id="152" stoichiometry="3" points="1611 2209" /> <Input id="148" stoichiometry="3" points="1683 2245" /> <Input id="146" stoichiometry="3" points="1638 2244" /> </Inputs> <Outputs> <Output id="142" stoichiometry="4" points="1814 2207" /> <Output id="143" points="1862 2118" /> <Output id="150" stoichiometry="3" points="1792 2244" /> </Outputs> <Catalysts> <Catalyst id="144" points="1719 2176" /> </Catalysts> <Properties> <displayName>4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="194642" points="1938 2047, 1938 2005, 1941 1961" position="1938 2005" lineWidth="1.0"> <Inputs> <Input id="143" points="1896 2081" /> <Input id="2275" points="1974 2088" /> </Inputs> <Outputs> <Output id="156" points="1901 1919" /> <Output id="159" points="1977 1941" /> <Output id="161" points="1983 1986" /> <Output id="2273" points="2027 1958" /> </Outputs> <Catalysts> <Catalyst id="157" points="1909 2002" /> </Catalysts> <Properties> <displayName>4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="164" reactomeId="194689" points="1948 1854, 1948 1830, 1948 1789" position="1948 1830" lineWidth="1.0"> <Inputs> <Input id="156" points="1908 1882" /> <Input id="168" points="1988 1862" /> <Input id="170" points="1958 1868" /> </Inputs> <Outputs> <Output id="165" points="1911 1761" /> <Output id="172" points="1995 1784" /> </Outputs> <Catalysts> <Catalyst id="295" points="1919 1831" /> </Catalysts> <Properties> <displayName>4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="194669" points="1893 1664, 1893 1632, 1893 1595" position="1893 1632" lineWidth="1.0"> <Inputs> <Input id="165" points="1893 1724" /> <Input id="178" stoichiometry="3" points="1975 1706" /> <Input id="180" stoichiometry="3" points="1988 1669" /> <Input id="184" stoichiometry="3" points="1954 1735" /> </Inputs> <Outputs> <Output id="175" stoichiometry="4" points="1967 1569" /> <Output id="176" points="1893 1178" /> <Output id="182" stoichiometry="3" points="1972 1599" /> </Outputs> <Catalysts> <Catalyst id="144" points="1720 2147, 1724 1630" /> </Catalysts> <Properties> <displayName>4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="194718" points="1893 1108, 1894 1086, 1893 1059" position="1894 1086" lineWidth="1.0"> <Inputs> <Input id="176" points="1893 1141" /> <Input id="188" points="1957 1138" /> </Inputs> <Outputs> <Output id="187" points="1893 989" /> <Output id="189" points="1970 1030" /> <Output id="192" points="1992 1067" /> <Output id="194" points="1931 1023" /> </Outputs> <Catalysts> <Catalyst id="157" points="1855 1999, 1795 1994, 1795 1086" /> </Catalysts> <Properties> <displayName>4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="248" reactomeId="194632" points="1944 950, 1943 924, 1942 877" position="1943 924" lineWidth="1.0"> <Inputs> <Input id="187" points="1930 956" /> <Input id="251" points="1986 957" /> <Input id="194" points="1945 986" /> </Inputs> <Outputs> <Output id="249" points="1907 839" /> <Output id="255" points="1964 842" /> </Outputs> <Catalysts> <Catalyst id="295" points="1877 1818, 1836 1745, 1831 927" /> </Catalysts> <Properties> <displayName>Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="257" reactomeId="195690" points="1903 802, 1936 749, 1895 686" position="1936 749" lineWidth="1.0"> <Inputs> <Input id="249" /> </Inputs> <Outputs> <Output id="258" /> </Outputs> <Catalysts> <Catalyst id="259" points="1904 748" /> </Catalysts> <Properties> <displayName>Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="195664" points="1941 642, 1941 614, 1940 584" position="1941 614" lineWidth="1.0"> <Inputs> <Input id="258" points="1918 654" /> <Input id="267" points="1958 694" /> <Input id="271" points="1989 657" /> <Input id="273" points="1994 688" /> </Inputs> <Outputs> <Output id="263" stoichiometry="2" points="1997 600" /> <Output id="264" points="1905 540" /> <Output id="269" points="1988 570" /> </Outputs> <Catalysts> <Catalyst id="265" points="1911 614" /> </Catalysts> <Properties> <displayName>Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="196402" points="1938 477, 1939 436, 1939 404" position="1939 436" lineWidth="1.0"> <Inputs> <Input id="264" points="1909 503" /> <Input id="282" points="1989 492" /> <Input id="284" points="1990 464" /> </Inputs> <Outputs> <Output id="277" points="1899 369" /> <Output id="280" points="1988 392" /> </Outputs> <Catalysts> <Catalyst id="278" points="1908 429" /> </Catalysts> <Properties> <displayName>Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="285" reactomeId="196417" points="1941 314, 1940 276, 1941 239" position="1940 276" lineWidth="1.0"> <Inputs> <Input id="277" points="1908 332" /> <Input id="291" points="1990 288" /> <Input id="293" points="1989 320" /> </Inputs> <Outputs> <Output id="286" points="1833 210" /> <Output id="289" points="2001 195" /> </Outputs> <Catalysts> <Catalyst id="287" points="1906 274" /> </Catalysts> <Properties> <displayName>Reduction of desmosterol to cholesterol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="315" reactomeId="5250531" points="1804 186, 1804 108, 1804 55" position="1804 108" lineWidth="1.0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="316" /> </Outputs> <Catalysts> <Catalyst id="317" points="1885 182, 1865 107" /> </Catalysts> <Properties> <displayName>ARV1 transports CHOL from ER membrane to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="318" reactomeId="6807064" points="798 152, 848 152, 883 152" position="848 152" lineWidth="1.0"> <Inputs> <Input id="325" points="786 125" /> <Input id="327" points="745 127" /> <Input id="2289" points="831 226, 800 210" /> </Inputs> <Outputs> <Output id="319" points="926 198" /> <Output id="321" points="895 122" /> </Outputs> <Catalysts> <Catalyst id="323" points="846 181" /> </Catalysts> <Properties> <displayName>DHCR24 reduces ZYMOL to ZYMSTNL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="329" reactomeId="6807052" points="965 198, 1045 151, 1093 180" position="1045 151" lineWidth="1.0"> <Inputs> <Input id="319" /> </Inputs> <Outputs> <Output id="330" /> </Outputs> <Catalysts> <Catalyst id="332" points="1045 185" /> </Catalysts> <Properties> <displayName>EBP isomerizes ZYMSTNL to LTHSOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="334" reactomeId="6807053" points="1177 150, 1251 151, 1325 151" position="1251 151" lineWidth="1.0"> <Inputs> <Input id="330" points="1136 180" /> <Input id="338" stoichiometry="2" points="1135 142" /> <Input id="344" points="1156 120" /> <Input id="2485" stoichiometry="2" points="1190 184" /> </Inputs> <Outputs> <Output id="2475" stoichiometry="2" points="1358 125" /> <Output id="335" points="1382 184" /> <Output id="2483" stoichiometry="2" points="1312 181" /> </Outputs> <Catalysts> <Catalyst id="346" points="1251 189" /> </Catalysts> <Properties> <displayName>SC5D desaturates LTHSOL to 7-dehydroCHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="347" reactomeId="6807055" points="1619 157, 1664 157, 1700 157" position="1664 157" lineWidth="1.0"> <Inputs> <Input id="335" points="1417 184, 1437 157" /> <Input id="349" points="1611 110" /> <Input id="351" points="1588 138" /> </Inputs> <Outputs> <Output id="286" points="1788 186, 1754 157" /> <Output id="353" points="1723 127" /> </Outputs> <Catalysts> <Catalyst id="355" points="1664 183" /> </Catalysts> <Properties> <displayName>DHCR7 reduces 7-dehydroCHOL to CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="667" reactomeId="8848215" points="335 93, 334 132, 335 162" position="334 132" lineWidth="1.0"> <Inputs> <Input id="62" stoichiometry="2" /> </Inputs> <Outputs> <Output id="31" points="371 176" /> <Output id="51" points="336 295" /> <Output id="862" points="312 181" /> </Outputs> <Catalysts> <Catalyst id="668" points="301 132" /> </Catalysts> <Properties> <displayName>ACAT2 condenses 2 Ac-CoA to form ACA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1424" reactomeId="8952137" points="362 1699, 361 1755, 361 1804" position="361 1755" lineWidth="1.0"> <Inputs> <Input id="1448" points="345 1686" /> <Input id="59" points="453 1662" /> </Inputs> <Outputs> <Output id="1425" points="362 1853" /> <Output id="1450" points="388 1823" /> <Output id="2259" points="331 1820" /> </Outputs> <Catalysts> <Catalyst id="1426" points="75 1759" /> </Catalysts> <Properties> <displayName>Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1477" interactionType="Activate" points="1467 202, 1506 203" position="1486 202" lineWidth="2.0"> <Inputs> <Input id="335" /> </Inputs> <Outputs> <Output id="1476" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1611" reactomeId="9705584" points="661 474, 681 524, 774 526" position="681 524" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="16" points="795 433" /> <Input id="1612" points="643 465" /> </Inputs> <Outputs> <Output id="1613" /> </Outputs> <Properties> <displayName>HMGCR dimer binds statins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1874" reactomeId="9717834" points="540 1023, 540 1046, 540 1068" position="540 1046" lineWidth="1.0"> <Inputs> <Input id="33" points="409 990" /> <Input id="99" points="506 997" /> </Inputs> <Outputs> <Output id="23" points="460 1054" /> <Output id="102" points="458 1133" /> </Outputs> <Catalysts> <Catalyst id="1875" points="567 1055" /> </Catalysts> <Properties> <displayName>GGPS1 hexamer transfers IPPP to DMAPP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1876" reactomeId="9717830" points="518 1051, 518 1105, 518 1126" position="518 1105" lineWidth="1.0"> <Inputs> <Input id="99" points="490 1002" /> <Input id="23" points="460 1051" /> </Inputs> <Outputs> <Output id="28" points="527 1150" /> <Output id="102" points="458 1141" /> </Outputs> <Catalysts> <Catalyst id="1875" points="567 1085" /> </Catalysts> <Properties> <displayName>GGPS1 hexamer transfers IPPP to GPP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2132" reactomeId="9717841" points="203 1076, 203 1077, 206 1014" position="203 1077" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2133" points="203 1125" /> <Input id="1728" points="238 1076" /> </Inputs> <Outputs> <Output id="2134" /> </Outputs> <Properties> <displayName>holo-FDPS dimer binds NBPs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2138" reactomeId="9755937" points="919 2127, 919 2099, 919 2074" position="919 2099" lineWidth="1.0"> <Inputs> <Input id="64" points="951 2146" /> <Input id="2143" points="863 2176" /> <Input id="2145" points="813 2173" /> </Inputs> <Outputs> <Output id="2139" points="919 2049" /> <Output id="2147" points="787 2066" /> </Outputs> <Catalysts> <Catalyst id="2141" points="867 2099" /> </Catalysts> <Activators> <Activator id="2220" points="1035 2099" /> </Activators> <Properties> <displayName>DHCR24 reduces LAN to 24,25-dhLAN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2276" reactomeId="9945804" points="929 345, 930 313, 930 268" position="930 313" lineWidth="1.0"> <Inputs> <Input id="2277" points="930 363" /> <Input id="2283" points="809 338" /> <Input id="2285" points="803 371" /> </Inputs> <Outputs> <Output id="319" points="937 235" /> <Output id="2281" points="826 267" /> </Outputs> <Catalysts> <Catalyst id="2279" points="970 313" /> </Catalysts> <Properties> <displayName>HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2290" reactomeId="9945787" points="931 523, 933 484, 932 461" position="933 484" lineWidth="1.0"> <Inputs> <Input id="2291" points="931 611" /> <Input id="2299" points="782 584, 873 576" /> </Inputs> <Outputs> <Output id="2277" points="932 414" /> <Output id="2295" points="776 485" /> <Output id="2297" points="826 458" /> </Outputs> <Catalysts> <Catalyst id="2293" points="982 484" /> </Catalysts> <Properties> <displayName>NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2324" reactomeId="9945784" points="931 1066, 930 1017, 930 980" position="930 1017" lineWidth="1.0"> <Inputs> <Input id="2325" points="929 1099" /> <Input id="2328" points="770 1065" /> <Input id="2330" points="782 1107" /> </Inputs> <Outputs> <Output id="2326" points="930 938" /> <Output id="2332" points="782 951" /> </Outputs> <Catalysts> <Catalyst id="2441" points="886 1015" /> </Catalysts> <Properties> <displayName>HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2339" reactomeId="9945822" points="927 1254, 928 1219, 928 1185" position="928 1219" lineWidth="1.0"> <Inputs> <Input id="2340" points="927 1268" /> <Input id="2342" points="788 1252" /> </Inputs> <Outputs> <Output id="2325" points="928 1150" /> <Output id="2330" points="782 1127" /> <Output id="2346" points="773 1168" /> </Outputs> <Catalysts> <Catalyst id="2443" points="873 1214" /> </Catalysts> <Properties> <displayName>NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2359" reactomeId="9946140" points="923 1626, 925 1592, 925 1570" position="925 1592" lineWidth="1.0"> <Inputs> <Input id="2360" points="924 1656" /> <Input id="2369" points="793 1616" /> <Input id="2371" points="771 1660" /> </Inputs> <Outputs> <Output id="2361" points="925 1545" /> <Output id="2365" points="788 1570" /> </Outputs> <Catalysts> <Catalyst id="2363" points="976 1592" /> </Catalysts> <Properties> <displayName>TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2392" reactomeId="9947148" points="919 1991, 919 1944, 919 1860" position="919 1944" lineWidth="1.0"> <Inputs> <Input id="2393" stoichiometry="3" points="873 1985" /> <Input id="2399" stoichiometry="3" points="841 2017" /> <Input id="2139" points="919 2012" /> </Inputs> <Outputs> <Output id="2394" stoichiometry="4" points="810 1862" /> <Output id="2395" stoichiometry="3" points="852 1900" /> <Output id="2360" points="924 1707" /> <Output id="2401" points="796 1831" /> <Output id="2403" stoichiometry="4" points="832 1807" /> </Outputs> <Catalysts> <Catalyst id="2397" points="872 1946" /> </Catalysts> <Properties> <displayName>CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2422" reactomeId="9947203" points="924 1455, 924 1401, 925 1367" position="924 1401" lineWidth="1.0"> <Inputs> <Input id="2361" points="925 1494" /> <Input id="2425" stoichiometry="3" points="773 1466" /> <Input id="2431" stoichiometry="6" points="860 1441" /> <Input id="2433" stoichiometry="5" points="774 1515" /> </Inputs> <Outputs> <Output id="2340" points="926 1333" /> <Output id="2429" stoichiometry="6" points="860 1363" /> <Output id="2435" stoichiometry="4" points="778 1308" /> </Outputs> <Catalysts> <Catalyst id="2427" points="868 1398" /> </Catalysts> <Properties> <displayName>MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2458" reactomeId="9947207" points="935 839, 934 766, 932 711" position="934 766" lineWidth="1.0"> <Inputs> <Input id="2326" points="932 887" /> <Input id="2465" stoichiometry="6" points="860 820" /> <Input id="2469" stoichiometry="3" points="769 839" /> <Input id="2471" stoichiometry="5" points="770 886" /> </Inputs> <Outputs> <Output id="2459" stoichiometry="4" points="774 670" /> <Output id="2291" points="931 662" /> <Output id="2463" stoichiometry="6" points="873 719" /> </Outputs> <Catalysts> <Catalyst id="2461" points="869 766" /> </Catalysts> <Properties> <displayName>MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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