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Details on Person PIAS1,2-1 SUMOylates XRCC4 with SUMO1

Class:Id	Reaction:4568848
_displayName	PIAS1,2-1 SUMOylates XRCC4 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:40:06
authored	[InstanceEdit:4551770] May, B, 2013-09-14
catalystActivity	[CatalystActivity:4090313] SUMO transferase activity of PIAS1,2-1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643459] SUMO transferase activity of PIAS1,2-1 [nucleoplasm] An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4568862] May, B, 2013-09-19
edited	[InstanceEdit:4551770] May, B, 2013-09-14
input	[EntityWithAccessionedSequence:75911] XRCC4 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4568901] SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair
modified	[InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1,2-1 SUMOylates XRCC4 with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4568892] monoSUMO1-K210-XRCC4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679791] R-HSA-4568848.4
summation	[Summation:4568907] PIAS1,2-1 SUMOylate XRCC4 at lysine-210 with SUMO1 (Yurchenk...
(hasEvent)	[Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775048] Update Tracker - [Reaction:4568848] PIAS1,2-1 SUMOylates XRCC4 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (4568848)