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Details on Person PIAS4 SUMOylates RNF168 with SUMO1

Class:Id	Reaction:4551661
_displayName	PIAS4 SUMOylates RNF168 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:42:33
authored	[InstanceEdit:4551677] May, B, 2013-09-13
catalystActivity	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643693] SUMO transferase activity of PIAS4 [nucleoplasm] PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4551601] May, B, 2013-09-14
edited	[InstanceEdit:4551677] May, B, 2013-09-13
input	[EntityWithAccessionedSequence:4551605] RNF168 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4551664] DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
modified	[InstanceEdit:5228465] May, B, 2014-01-12 [InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS4 SUMOylates RNF168 with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4551750] monoSUMO1-RNF168 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680132] R-HSA-4551661.4
summation	[Summation:4551747] PIAS4 SUMOylates RNF168 at an unknown lysine residue (Daniel...
(hasEvent)	[Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774867] Update Tracker - [Reaction:4551661] PIAS4 SUMOylates RNF168 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by PIAS4 SUMOylates RNF168 with SUMO1 (4551661)