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Details on Person PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex

Class:Id	Reaction:453342
_displayName	PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex
_doRelease	TRUE
_timestamp	2026-02-27 17:33:55
authored	[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
catalystActivity	[CatalystActivity:9931448] AMP binding activity of PYGM dimer, b form [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:453352] D'Eustachio, P, 2010-01-21
input	[Complex:71538] PYGM dimer, b form [cytosol] [Homo sapiens] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:76577] AMP [cytosol]
internalReviewed	[InstanceEdit:9939460] D'Eustachio, Peter, 2025-02-27
isChimeric	FALSE
literatureReference	[LiteratureReference:453326] Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core
modified	[InstanceEdit:453376] D'Eustachio, P, 2010-01-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9772993] D'Eustachio, Peter, 2022-04-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11 [InstanceEdit:9931476] D'Eustachio, Peter, 2024-12-11 [InstanceEdit:9939595] Matthews, Lisa, 2025-03-04 [InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02 [InstanceEdit:9983805] D'Eustachio, Peter, 2026-02-27
name	PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex
negativePrecedingEvent	[NegativePrecedingEvent:9931461] Different Cell Type: PYGB b dimer:AMP complex => PGYB dimer, b form + 2 AMP
output	[Complex:453344] PYGM b dimer:AMP [cytosol] [Homo sapiens]
precedingEvent	[Reaction:453338] PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:453366] Negative regulation by 'ATP [cytosol]' [NegativeRegulation:453374] Negative regulation by 'G6P [cytosol]'
releaseDate	2009-12-15
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104683] R-HSA-453342.8
structureModified	[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
summation	[Summation:453364] Cytosolic, non-phosphorylated PGYM dimers (b form) can rever...
(hasEvent)	[Pathway:70221] Glycogen breakdown (glycogenolysis) [Homo sapiens]
(inferredFrom)	[Reaction:453356] PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9983804] Futile Cycle: PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex [Reaction:71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Homo sapiens] [Reaction:453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939653] Update Tracker - [Reaction:453342] PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex - v92:[removeCatalystActivity]
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No pathways have been reviewed or authored by PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (453342)