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Details on Person Diagram of Signaling by TGF-beta Receptor Complex, SMAD4 MH2 Domain Mutants in Cancer, SMAD2/3 Phosphorylation Motif Mutants in Cancer, SMAD2/3 MH2 Domain Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, and TGFBR1 LBD Mutants in Cancer
| Class:Id | PathwayDiagram:453316 |
|---|---|
| _displayName | Diagram of Signaling by TGF-beta Receptor Complex, SMAD4 MH2 Domain Mutants in Cancer, SMAD2/3 Phosphorylation Motif Mutants in Cancer, SMAD2/3 MH2 Domain Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, and TGFBR1 LBD Mutants in Cancer |
| _timestamp | 2023-08-01 14:33:03 |
| created | [InstanceEdit:453315] Jassal, B, 2010-01-21 |
| height | 1502 |
| modified | [InstanceEdit:453317] Jassal, B, 2010-01-21 [InstanceEdit:453318] Jassal, B, 2010-01-21 [InstanceEdit:1484110] Orlic-Milacic, Marija, 2011-08-12 [InstanceEdit:1530024] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2031335] Orlic-Milacic, M, 2012-01-05 [InstanceEdit:2031337] Orlic-Milacic, M, 2012-01-05 [InstanceEdit:2106578] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2106583] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2106593] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2127262] Orlic-Milacic, M, 2012-02-14 [InstanceEdit:2127267] Orlic-Milacic, M, 2012-02-14 [InstanceEdit:2127612] Orlic-Milacic, M, 2012-02-16 [InstanceEdit:2128992] Orlic-Milacic, M, 2012-02-17 [InstanceEdit:2130225] Orlic-Milacic, M, 2012-02-21 [InstanceEdit:2134523] Orlic-Milacic, M, 2012-02-23 [InstanceEdit:2134536] Orlic-Milacic, M, 2012-02-23 [InstanceEdit:2160941] Orlic-Milacic, M, 2012-03-05 [InstanceEdit:2160942] Orlic-Milacic, M, 2012-03-05 [InstanceEdit:2161139] Orlic-Milacic, M, 2012-03-08 [InstanceEdit:2161168] Orlic-Milacic, M, 2012-03-08 [InstanceEdit:2167891] Orlic-Milacic, M, 2012-03-22 [InstanceEdit:2167928] Orlic-Milacic, M, 2012-03-23 [InstanceEdit:2168066] Jupe, S, 2012-03-23 [InstanceEdit:2172130] Orlic-Milacic, M, 2012-03-28 [InstanceEdit:2173141] Orlic-Milacic, M, 2012-03-30 [InstanceEdit:2173797] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2176402] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2176423] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2176459] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2179281] Orlic-Milacic, M, 2012-04-03 [InstanceEdit:2179295] Orlic-Milacic, M, 2012-04-03 [InstanceEdit:2179314] Orlic-Milacic, M, 2012-04-03 [InstanceEdit:2179334] Orlic-Milacic, M, 2012-04-03 [InstanceEdit:2186790] Orlic-Milacic, M, 2012-04-05 [InstanceEdit:2187283] Orlic-Milacic, M, 2012-04-08 [InstanceEdit:2187364] Orlic-Milacic, M, 2012-04-09 [InstanceEdit:2187386] Orlic-Milacic, M, 2012-04-09 [InstanceEdit:2187411] Orlic-Milacic, M, 2012-04-09 [InstanceEdit:2187531] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2190621] Orlic-Milacic, M, 2012-04-11 [InstanceEdit:2197824] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2198462] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2198463] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2262787] Orlic-Milacic, M, 2012-05-21 [InstanceEdit:2262795] Orlic-Milacic, M, 2012-05-21 [InstanceEdit:3006683] Orlic-Milacic, M, 2013-01-31 [InstanceEdit:3009229] Orlic-Milacic, M, 2013-02-04 [InstanceEdit:3009235] Orlic-Milacic, M, 2013-02-04 [InstanceEdit:3009245] Orlic-Milacic, M, 2013-02-04 [InstanceEdit:3027891] Orlic-Milacic, M, 2013-02-05 [InstanceEdit:3168197] Orlic-Milacic, M, 2013-02-24 [InstanceEdit:3304398] Orlic-Milacic, M, 2013-04-23 [InstanceEdit:3305863] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3307181] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3309638] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3309640] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3311023] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3311024] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3313042] Orlic-Milacic, M, 2013-04-24 [InstanceEdit:3315491] Orlic-Milacic, M, 2013-04-25 [InstanceEdit:3642288] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3642289] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3645791] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3645794] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3649978] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3656493] Orlic-Milacic, M, 2013-06-05 [InstanceEdit:3656540] Orlic-Milacic, M, 2013-06-05 [InstanceEdit:3656541] Orlic-Milacic, M, 2013-06-05 [InstanceEdit:3702194] Orlic-Milacic, M, 2013-06-13 [InstanceEdit:3707876] Orlic-Milacic, M, 2013-06-13 [InstanceEdit:3713562] Orlic-Milacic, M, 2013-06-13 [InstanceEdit:3719245] Orlic-Milacic, M, 2013-06-13 [InstanceEdit:3724920] Orlic-Milacic, M, 2013-06-13 [InstanceEdit:4205116] Orlic-Milacic, M, 2013-08-15 [InstanceEdit:4218343] Orlic-Milacic, M, 2013-08-15 [InstanceEdit:4332241] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:4332289] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:4333394] Orlic-Milacic, M, 2013-08-17 [InstanceEdit:4419909] Orlic-Milacic, M, 2013-08-28 [InstanceEdit:8951775] Rothfels, Karen, 2016-12-09 [InstanceEdit:9603927] Shamovsky, Veronica, 2018-03-28 [InstanceEdit:9675160] D'Eustachio, Peter, 2020-01-31 [InstanceEdit:9675161] D'Eustachio, Peter, 2020-01-31 [InstanceEdit:9731422] Orlic-Milacic, Marija, 2021-05-20 [InstanceEdit:9734552] Orlic-Milacic, Marija, 2021-06-17 [InstanceEdit:9736818] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736819] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736821] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736829] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736830] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736831] Orlic-Milacic, Marija, 2021-07-14 [InstanceEdit:9736928] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9736999] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9737408] Orlic-Milacic, Marija, 2021-07-19 [InstanceEdit:9737412] Orlic-Milacic, Marija, 2021-07-19 [InstanceEdit:9737421] Orlic-Milacic, Marija, 2021-07-19 [InstanceEdit:9737583] Orlic-Milacic, Marija, 2021-07-20 [InstanceEdit:9737597] Orlic-Milacic, Marija, 2021-07-20 [InstanceEdit:9748696] Orlic-Milacic, Marija, 2021-07-26 [InstanceEdit:9748699] Orlic-Milacic, Marija, 2021-07-26 [InstanceEdit:9748709] Orlic-Milacic, Marija, 2021-07-26 [InstanceEdit:9748714] Orlic-Milacic, Marija, 2021-07-26 [InstanceEdit:9749415] Varusai, Thawfeek, 2021-08-03 [InstanceEdit:9751074] Orlic-Milacic, Marija, 2021-08-17 [InstanceEdit:9751111] Orlic-Milacic, Marija, 2021-08-18 [InstanceEdit:9751257] Matthews, Lisa, 2021-08-24 [InstanceEdit:9753482] Orlic-Milacic, Marija, 2021-09-07 [InstanceEdit:9753486] Orlic-Milacic, Marija, 2021-09-07 [InstanceEdit:9764251] May, Bruce, 2022-02-10 [InstanceEdit:9840921] Tiwari, Krishna, 2023-08-01 |
| representedPathway | [Pathway:170834] Signaling by TGF-beta Receptor Complex [Homo sapiens] [Pathway:3311021] SMAD4 MH2 Domain Mutants in Cancer [Homo sapiens] [Pathway:3304356] SMAD2/3 Phosphorylation Motif Mutants in Cancer [Homo sapiens] [Pathway:3315487] SMAD2/3 MH2 Domain Mutants in Cancer [Homo sapiens] [Pathway:3642279] TGFBR2 MSI Frameshift Mutants in Cancer [Homo sapiens] [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer [Homo sapiens] [Pathway:3656532] TGFBR1 KD Mutants in Cancer [Homo sapiens] [Pathway:3656535] TGFBR1 LBD Mutants in Cancer [Homo sapiens] |
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textPosition="1323 1413"> <Properties> <displayName>NEDD4L</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="231" reactomeId="2176418" position="1600 1424" bounds="1549 1413 102 22" textPosition="1549 1413" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SMAD7:NEDD4L</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="237" reactomeId="2176419" position="1950 980" bounds="1919 963 63 35" textPosition="1922 962" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="243" reactomeId="2176415" position="1891 662" bounds="1861 643 60 39" textPosition="1863 644"> <Properties> <displayName>SMURF/NEDD4L</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="317" reactomeId="2176457" position="1203 748" bounds="1173 731 61 35" textPosition="1176 730" bgColor="204 255 255" hideComponents="true"> 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hideComponents="true"> <Properties> <displayName>p-2S-SMAD2/3:PMEPA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="413" reactomeId="2186792" position="1106 626" bounds="1079 616 55 21" textPosition="1079 616" /> <org.gk.render.RenderableComplex id="414" reactomeId="2187341" position="1176 633" bounds="1142 616 68 35" textPosition="1142 615" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SMAD2/3:PMEPA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="466" reactomeId="170855" position="1172 803" bounds="1146 794 52 18" textPosition="1147 792"> <Properties> <displayName>SMAD3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="468" reactomeId="975970" position="1121 856" bounds="1097 845 48 22" textPosition="1098 845"> <Properties> <displayName>STUB1</displayName> </Properties> </org.gk.render.RenderableProtein> 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bounds="719 865 36 22" textPosition="719 865"> <Properties> <isChanged>true</isChanged> <displayName>Note</displayName> </Properties> </org.gk.render.Note> <org.gk.render.Note id="516" position="893 999" bounds="856 977 74 44" textPosition="857 974"> <Properties> <isChanged>true</isChanged> <displayName>early endosome membrane</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableProtein id="517" reactomeId="206180" position="1140 914" bounds="1104 904 72 21" textPosition="1107 904"> <Properties> <displayName>ZFYVE9-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="518" reactomeId="975972" position="644 1036" bounds="614 1026 60 21" textPosition="617 1026" /> <org.gk.render.RenderableProtein id="520" reactomeId="3004548" position="1452 1396" bounds="1423 1385 58 22" textPosition="1425 1385"> <Properties> <displayName>SMURF1</displayName> </Properties> </org.gk.render.RenderableProtein> 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bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TGFB3:LAP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="972" reactomeId="171175" position="1014 1239" bounds="960 1220 109 38" textPosition="964 1221" bgColor="204 255 255"> <Properties> <displayName>p-2S-SMAD2,3:SMAD4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1229" reactomeId="9736753" position="956 667" bounds="909 656 95 23" textPosition="909 657" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SMAD2:SMAD4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1230" reactomeId="201645" position="834 904" bounds="804 893 60 23" textPosition="804 893"> <Properties> <displayName>ZFYVE16</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1232" reactomeId="170839" position="523 1346" bounds="492 1335 63 23" textPosition="496 1335"> <Properties> <displayName>TGFBR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1233" reactomeId="170863" position="522 1445" bounds="487 1434 70 23" textPosition="487 1435" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-TGFBR1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1234" reactomeId="1655764" position="624 1397" bounds="568 1386 112 23" textPosition="568 1386"> <Properties> <displayName>SREBF1-1(1-490)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1252" reactomeId="2395330" position="769 238" bounds="724 228 90 21" textPosition="737 228"> <Properties> <displayName>TGFB:LAP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1255" reactomeId="2395372" position="821 359" bounds="791 343 61 32" textPosition="795 341"> <Properties> <displayName>LTBP1, LTBP3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1256" reactomeId="2395250" position="1051 293" bounds="1006 278 91 31" textPosition="1007 276"> <Properties> <displayName>LTBP1,LTBP3:TGFB:LAP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1271" reactomeId="2395236" position="381 280" bounds="338 269 86 23" textPosition="341 270" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TGFB1:LAP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1274" reactomeId="2161309" position="331 121" bounds="307 111 48 20" textPosition="309 110"> <Properties> <displayName>LTBP4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1275" reactomeId="2395326" position="585 220" bounds="526 208 119 25" textPosition="526 211" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LTBP4:TGFB1:LAP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1277" reactomeId="2396176" position="874 66" bounds="798 56 153 21" textPosition="804 56"> <Properties> <displayName>LAP1 binding-integrins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1278" reactomeId="9737594" position="983 197" bounds="923 186 121 23" textPosition="924 187" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LTBP1:TGFB1:LAP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1279" reactomeId="2396201" position="1185 79" bounds="1118 54 135 50" textPosition="1124 54" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LTBP1:TGFB1:LAP1:LAP1-binding integrins</displayName> </Properties> </org.gk.render.RenderableComplex> 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<org.gk.render.RenderableEntity id="1286" reactomeId="2159874" position="93 230" bounds="54 218 78 25" textPosition="61 219"> <Properties> <displayName>Fibrillin-1</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntitySet id="1287" reactomeId="2396175" position="189 153" bounds="161 140 56 26" textPosition="168 142"> <Properties> <displayName>LTBPs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1290" reactomeId="2396177" position="177 370" bounds="116 359 123 22" textPosition="126 359" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LTBPs:Fibrillin-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1292" reactomeId="9748703" position="1533 83" bounds="1469 58 129 50" textPosition="1471 58" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LTBP1:TGFB1:LAP1:LAP1-binding integrins:Fibronectin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1293" reactomeId="419057" position="1327 42" bounds="1293 26 69 33" textPosition="1301 25"> <Properties> <displayName>ROCK1,ROCK2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1294" reactomeId="9748705" position="1413 78" bounds="1377 62 73 33" textPosition="1379 59" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Thrombin:F2R</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1295" reactomeId="4332222" position="689 563" bounds="637 543 105 40" textPosition="643 545"> <Properties> <displayName>NEDD8-K556,K567-TGFBR2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16666666666666666" relativeY="0.0" label="Nd" trackId="0" reactomeId="4419898" /> <org.gk.render.RenderableFeature relativeX="0.3476190476190476" relativeY="0.0" label="Nd" trackId="0" reactomeId="4419903" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1296" reactomeId="9839341" position="914 502" bounds="857 484 115 37" textPosition="857 485" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TGFB1_2:TGFBR3:TGFBR2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1297" reactomeId="9839334" position="547 480" bounds="507 462 81 37" textPosition="507 463" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TGFBR3_sol:TGFB1/2</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="28" reactomeId="170844" points="134 656, 164 658, 217 659" position="164 658" lineWidth="1.0"> <Inputs> <Input id="3" /> </Inputs> <Outputs> <Output id="746" /> </Outputs> <Catalysts> <Catalyst id="5" points="193 582" /> </Catalysts> <Properties> <displayName>Latent TGF-beta-1 is cleaved by FURIN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="177107" points="285 641, 377 578, 380 295" position="377 578" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="746" /> </Inputs> <Outputs> <Output id="1271" /> </Outputs> <Properties> <displayName>Secretion and activation of the latent large complex of TGF-beta-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="170861" points="621 525, 652 519, 683 516" position="652 519" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="527" stoichiometry="2" points="581 540" /> <Input id="6" points="621 455" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Inhibitors> <Inhibitor id="1297" points="591 495" /> </Inhibitors> <Activators> <Activator id="1296" points="854 490, 698 457" /> </Activators> <Properties> <displayName>Dimeric TGF-beta-1 binds to the receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="170846" points="826 539, 842 543, 853 591" position="842 543" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" points="814 533" /> <Input id="405" stoichiometry="2" points="808 576" /> </Inputs> <Outputs> <Output id="10" points="876 578" /> <Output id="406" stoichiometry="2" points="864 640" /> </Outputs> <Activators> <Activator id="1296" points="881 524" /> </Activators> <Properties> <displayName>TGFBR2 recruits TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="32" reactomeId="170843" points="988 560, 1008 562, 1027 563" position="1008 562" lineWidth="1.0"> <Inputs> <Input id="10" points="968 558" /> <Input id="22" stoichiometry="12" points="978 597" /> </Inputs> <Outputs> <Output id="11" points="1052 565" /> <Output id="23" stoichiometry="12" points="1032 599" /> </Outputs> <Catalysts> <Catalyst id="10" points="968 536, 989 525" /> </Catalysts> <Properties> <displayName>TGFBR2 phosphorylates TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="33" reactomeId="170835" points="1002 853, 1000 856, 986 890" position="1000 856" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="517" points="1116 901" /> <Input id="11" points="1087 595, 1027 661" /> <Input id="12" points="1060 788" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> <Properties> <displayName>An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="170868" points="961 980, 961 1003, 961 1022" position="961 1003" lineWidth="1.0"> <Inputs> <Input id="14" points="974 933" /> <Input id="15" stoichiometry="2" points="1001 974" /> </Inputs> <Outputs> <Output id="16" points="955 1063" /> <Output id="17" stoichiometry="2" points="997 1022" /> </Outputs> <Catalysts> <Catalyst id="14" points="963 933, 930 971" /> </Catalysts> <Properties> <displayName>Activated type I receptor phosphorylates SMAD2/3 directly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="170850" points="966 1103, 989 1132, 991 1136" position="989 1132" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="19" points="822 1245" /> <Output id="18" points="1084 1082" /> </Outputs> <Properties> <displayName>Phosphorylated SMAD2/3 dissociates from TGFBR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="37" interactionType="Activate" points="1075 1238, 1230 1237" position="1152 1237" lineWidth="2.0"> <Inputs> <Input id="972" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="55" reactomeId="2134506" points="510 735, 511 735, 512 761" position="511 735" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="405" stoichiometry="2" points="799 618, 795 734" /> <Input id="41" points="506 726" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> <Properties> <displayName>TGFBR1 is recruited to tight junctions by PARD6A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="2134532" points="524 912, 527 933, 527 953" position="527 933" lineWidth="1.0"> <Inputs> <Input id="44" stoichiometry="13" points="558 913" /> <Input id="43" points="522 893" /> </Inputs> <Outputs> <Output id="45" stoichiometry="13" points="564 954" /> <Output id="46" points="531 979" /> </Outputs> <Properties> <displayName>TGFBR2 phosphorylates TGFBR1 and PARD6A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="58" reactomeId="2160932" points="533 1034, 533 1046, 533 1074" position="533 1046" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="46" points="533 1022" /> <Input id="518" points="611 1035" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> <Properties> <displayName>SMURF1 binds phosphorylated PARD6A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="59" reactomeId="2160935" points="530 1133, 530 1154, 531 1176" position="530 1154" lineWidth="1.0"> <Inputs> <Input id="47" points="531 1118" /> <Input id="48" points="557 1134" /> </Inputs> <Outputs> <Output id="49" /> </Outputs> <Properties> <displayName>SMURF1 ubiquitinates RHOA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="60" reactomeId="2160931" points="554 1222, 597 1258, 598 1277" position="597 1258" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="49" /> </Inputs> <Properties> <displayName>Disassembly of tight junctions</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="2127562" points="1203 573, 1203 572, 1235 573" position="1203 572" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="1161 571" /> <Input id="72" points="1236 646" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Properties> <displayName>STRAP binds phosphorylated TGF-beta receptor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="173512" points="1410 650, 1411 651, 1481 622" position="1411 651" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="1430 720" /> <Input id="11" points="1161 583" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Properties> <displayName>I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="2128994" points="1386 628, 1386 628, 1454 572" position="1386 628" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="1428 720" /> <Input id="73" points="1325 598" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="178189" points="1481 894, 1481 894, 1330 959" position="1481 894" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="517" points="1179 911" /> <Input id="86" points="1513 637" /> <Input id="90" points="1481 928" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="178178" points="1276 1022, 1273 1045, 1273 1066, 1273 1066" position="1273 1045" lineWidth="1.0"> <Inputs> <Input id="98" stoichiometry="6" points="1323 1023" /> <Input id="91" points="1276 1013" /> </Inputs> <Outputs> <Output id="517" points="1146 928, 1181 976, 1232 1060" /> <Output id="99" stoichiometry="6" points="1330 1087" /> <Output id="90" points="1477 958, 1451 1050" /> <Output id="100" points="1270 1088" /> <Output id="85" points="1432 747, 1430 1030" /> </Outputs> <Catalysts> <Catalyst id="91" points="1260 1013, 1243 1034" /> </Catalysts> <Properties> <displayName>PP1 dephosphorylates TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="178208" points="1492 1319, 1492 1321, 1532 1324" position="1492 1321" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="107" points="1417 1317" /> <Input id="108" points="1474 1297" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Properties> <displayName>SMAD7 binds to SMURF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="110" interactionType="Activate" points="1398 1266, 1390 1303" position="1394 1284" lineWidth="2.0"> <Inputs> <Input id="27" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="111" reactomeId="2167876" points="1600 1314, 1738 1179, 1749 990" position="1738 1179" lineWidth="1.0"> <Inputs> <Input id="109" /> </Inputs> <Outputs> <Output id="112" /> </Outputs> <Properties> <displayName>SMAD7:SMURF2 complex translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="2167917" points="1507 1373, 1507 1374, 1537 1374" position="1507 1374" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="107" points="1412 1332" /> <Input id="520" points="1478 1382" /> </Inputs> <Outputs> <Output id="115" /> </Outputs> <Properties> <displayName>SMAD7 binds to SMURF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="2167924" points="1696 1378, 1695 1380, 1734 1374" position="1695 1380" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="115" points="1647 1377" /> <Input id="122" points="1682 1362" /> </Inputs> <Outputs> <Output id="123" /> </Outputs> <Properties> <displayName>SMAD7:SMURF1 complex binds XPO1 (CRM1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="178215" points="1775 1345, 1817 1177, 1849 1117" position="1817 1177" lineWidth="1.0"> <Inputs> <Input id="123" /> </Inputs> <Outputs> <Output id="125" points="1821 1093" /> <Output id="126" points="1854 992" /> </Outputs> <Catalysts> <Catalyst id="123" points="1769 1345, 1766 1234" /> </Catalysts> <Properties> <displayName>SMAD7:SMURF1 complex is exported to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="142" reactomeId="178218" points="1622 733, 1620 732, 1721 618" position="1620 732" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="1161 586" /> <Input id="509" points="1622 761" /> </Inputs> <Outputs> <Output id="503" /> </Outputs> <Properties> <displayName>SMAD7:SMURF complex binds to phosphorylated TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="144" points="1835 953, 1636 789" position="1735 871" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="126" /> </Inputs> <Outputs> <Output id="509" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="145" points="1739 951, 1630 789" position="1684 870" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="112" /> </Inputs> <Outputs> <Output id="509" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="152" reactomeId="2169050" points="1835 576, 1851 576, 1868 608" position="1851 576" lineWidth="1.0"> <Inputs> <Input id="157" stoichiometry="2" points="1813 642" /> <Input id="503" points="1807 578" /> </Inputs> <Outputs> <Output id="243" points="1882 637" /> <Output id="153" points="1906 594" /> </Outputs> <Catalysts> <Catalyst id="503" points="1807 556, 1834 541" /> </Catalysts> <Properties> <displayName>SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="2169046" points="1961 605, 1961 639, 1963 732" position="1961 639" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="153" /> </Inputs> <Properties> <displayName>Degradation of TGF-beta receptor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="229" reactomeId="2176416" points="1413 1424, 1416 1424, 1546 1424" position="1416 1424" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="107" points="1390 1332" /> <Input id="230" points="1382 1424" /> </Inputs> <Outputs> <Output id="231" /> </Outputs> <Properties> <displayName>NEDD4L ubiquitin ligase binds SMAD7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="236" reactomeId="2176417" points="1654 1421, 1851 1414, 1946 1001" position="1851 1414" lineWidth="1.0"> <Inputs> <Input id="231" /> </Inputs> <Outputs> <Output id="237" /> </Outputs> <Properties> <displayName>SMAD7:NEDD4L complex translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="240" points="1921 960, 1640 789" position="1780 874" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="237" /> </Inputs> <Outputs> <Output id="509" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="330" reactomeId="2176445" points="1131 705, 1132 705, 1174 728" position="1132 705" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="525" points="1135 724" /> <Input id="353" points="1152 692" /> </Inputs> <Outputs> <Output id="317" /> </Outputs> <Properties> <displayName>SMURF2 binds SMAD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="331" reactomeId="2176452" points="1339 753, 1338 766, 1339 787" position="1338 766" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="318" /> </Inputs> <Properties> <displayName>Degradation of ubiquitinated SMAD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="336" reactomeId="173542" points="1248 747, 1265 747, 1283 743" position="1265 747" lineWidth="1.0"> <Inputs> <Input id="317" points="1237 747" /> <Input id="338" points="1253 778" /> </Inputs> <Outputs> <Output id="318" points="1299 741" /> <Output id="353" points="1187 692" /> </Outputs> <Catalysts> <Catalyst id="317" points="1237 733, 1244 728" /> </Catalysts> <Properties> <displayName>SMURF2 ubiquitinates SMAD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="362" reactomeId="2179293" points="2028 639, 2029 636, 2057 626" position="2029 636" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="153" points="1988 605" /> <Input id="398" points="2015 652" /> </Inputs> <Outputs> <Output id="364" /> </Outputs> <Properties> <displayName>UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="400" reactomeId="2179291" points="2124 683, 2126 717, 2109 763" position="2126 717" lineWidth="1.0"> <Inputs> <Input id="401" stoichiometry="2" points="2103 684" /> <Input id="364" points="2115 626" /> </Inputs> <Outputs> <Output id="402" points="1643 612, 1915 809" /> <Output id="398" points="2027 705" /> <Output id="380" points="2087 793" /> </Outputs> <Catalysts> <Catalyst id="364" points="2124 626, 2160 697" /> </Catalysts> <Properties> <displayName>UCHL5, USP15 deubiquitinate TGFBR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="407" reactomeId="2187355" points="928 1200, 1106 1150" position="928 1200" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" points="828 1245" /> <Input id="408" points="1056 1131" /> </Inputs> <Outputs> <Output id="409" /> </Outputs> <Properties> <displayName>PMEPA1 sequesters phosphorylated SMAD2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="412" reactomeId="2187358" points="1097 676, 1096 676, 1143 654" position="1096 676" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="413" points="1104 640" /> <Input id="12" points="1073 754" /> </Inputs> <Outputs> <Output id="414" /> </Outputs> <Properties> <displayName>PMEPA1 sequesters unphosphorylated SMAD2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="465" reactomeId="2187375" points="1151 834, 1152 833, 1176 844" position="1152 833" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="466" points="1165 815" /> <Input id="468" points="1136 842" /> </Inputs> <Outputs> <Output id="469" /> </Outputs> <Properties> <displayName>SMAD3 binds STUB1 (CHIP)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="467" points="1143 797, 1100 788" position="1121 792" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="466" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="476" reactomeId="2187368" points="1253 850, 1270 850, 1286 850" position="1270 850" lineWidth="1.0"> <Inputs> <Input id="469" points="1235 852" /> <Input id="338" points="1254 812" /> </Inputs> <Outputs> <Output id="477" points="1302 850" /> <Output id="468" points="1148 864, 1240 897" /> </Outputs> <Catalysts> <Catalyst id="469" points="1235 863, 1252 870" /> </Catalysts> <Properties> <displayName>STUB1 (CHIP) ubiquitinates SMAD3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="488" reactomeId="2187382" points="1340 837, 1340 821, 1339 802" position="1340 821" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="477" /> </Inputs> <Properties> <displayName>Degradation of ubiquitinated SMAD3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="491" reactomeId="2187405" points="897 1126, 876 1102, 842 1067" position="876 1102" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="492" points="858 1117" /> <Input id="19" points="813 1245" /> </Inputs> <Outputs> <Output id="493" /> </Outputs> <Properties> <displayName>MTMR4 binds phosphorylated SMAD2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="494" reactomeId="2187401" points="822 1003, 821 976, 834 955" position="821 976" lineWidth="1.0"> <Inputs> <Input id="493" points="824 1024" /> <Input id="495" points="817 1002" /> </Inputs> <Outputs> <Output id="492" points="808 1099, 737 1054, 744 954" /> <Output id="12" points="1031 771, 994 771" /> <Output id="497" points="794 932" /> </Outputs> <Catalysts> <Catalyst id="493" points="838 1024, 852 1006" /> </Catalysts> <Properties> <displayName>MTMR4 dephosphorylates SMAD2/3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="510" reactomeId="2134519" points="512 809, 514 827, 517 838" position="514 827" lineWidth="1.0"> <Inputs> <Input id="42" points="512 801" /> <Input id="8" points="750 537, 784 797" /> </Inputs> <Outputs> <Output id="406" stoichiometry="2" points="866 668, 862 829" /> <Output id="43" points="518 851" /> </Outputs> <Properties> <displayName>TGFBR2 is recruited to tight junctions after TGF-beta stimulation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="526" points="1109 745, 1086 754" position="1097 749" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="525" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="540" reactomeId="173483" points="1343 657, 1343 657, 1378 575" position="1343 657" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="1420 720" /> <Input id="541" points="1305 685" /> <Input id="11" points="1161 588" /> </Inputs> <Outputs> <Output id="542" /> </Outputs> <Properties> <displayName>BAMBI interferes with the interaction of type I receptor with type II receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="564" reactomeId="4332235" points="528 582, 546 584, 567 589" position="546 584" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="527" points="540 566" /> <Input id="565" points="567 636" /> </Inputs> <Outputs> <Output id="566" /> </Outputs> <Properties> <displayName>CBL binds TGFBR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="695" reactomeId="4332236" points="649 615, 674 620, 682 601" position="674 620" lineWidth="1.0"> <Inputs> <Input id="566" points="632 607" /> <Input id="698" stoichiometry="2" points="643 658" /> </Inputs> <Outputs> <Output id="701" stoichiometry="2" points="719 660" /> <Output id="565" points="579 666, 598 724, 688 723" /> <Output id="1295" points="685 586" /> </Outputs> <Catalysts> <Catalyst id="566" points="632 597, 659 597" /> </Catalysts> <Properties> <displayName>CBL neddylates TGFBR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="702" reactomeId="9729936" points="143 742, 173 745, 214 745" position="173 745" lineWidth="1.0"> <Inputs> <Input id="703" /> </Inputs> <Outputs> <Output id="704" /> </Outputs> <Catalysts> <Catalyst id="5" points="196 582" /> </Catalysts> <Properties> <displayName>Latent TGF-beta-2 is cleaved by FURIN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="705" reactomeId="9729941" points="141 821, 183 817, 211 818" position="183 817" lineWidth="1.0"> <Inputs> <Input id="706" /> </Inputs> <Outputs> <Output id="707" /> </Outputs> <Catalysts> <Catalyst id="5" points="197 582" /> </Catalysts> <Properties> <displayName>Latent TGF-beta-3 is cleaved by FURIN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="808" reactomeId="9736809" points="304 736, 371 721, 453 342" position="371 721" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="704" /> </Inputs> <Outputs> <Output id="809" /> </Outputs> <Properties> <displayName>Secretion and activation of the latent large complex of TGF-beta-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="816" reactomeId="9736810" points="306 809, 373 794, 530 387" position="373 794" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="707" /> </Inputs> <Outputs> <Output id="817" /> </Outputs> <Properties> <displayName>Secretion and activation of the latent large complex of TGF-beta-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="974" reactomeId="170847" points="883 1293, 946 1306, 994 1264" position="946 1306" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" stoichiometry="3" points="836 1281" /> <Input id="20" stoichiometry="3" points="835 1344" /> </Inputs> <Outputs> <Output id="972" /> </Outputs> <Properties> <displayName>Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1249" reactomeId="9736756" points="522 1361, 522 1395, 522 1431" position="522 1395" lineWidth="1.0"> <Inputs> <Input id="1232" /> </Inputs> <Outputs> <Output id="1233" /> </Outputs> <Activators> <Activator id="1234" points="565 1395" /> </Activators> <Properties> <displayName>Cholesterol-dependent TGFB signaling activation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1250" reactomeId="9736767" points="945 747, 933 724, 951 682" position="933 724" lineWidth="1.0"> <Inputs> <Input id="20" points="827 1344" /> <Input id="525" points="1109 738" /> </Inputs> <Outputs> <Output id="1229" /> </Outputs> <Activators> <Activator id="1230" points="840 890" /> </Activators> <Properties> <displayName>Endofin facilitates the binding of SMAD2 with SMAD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1251" reactomeId="2395328" points="864 289, 924 292, 1000 292" position="924 292" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1252" points="788 255" /> <Input id="1255" stoichiometry="3" points="830 337" /> </Inputs> <Outputs> <Output id="1256" /> </Outputs> <Properties> <displayName>LTBP1, LTBP3 bind TGF-Beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1253" points="503 315, 732 255" position="617 285" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="809" /> </Inputs> <Outputs> <Output id="1252" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1254" points="557 357, 750 255" position="653 306" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="817" /> </Inputs> <Outputs> <Output id="1252" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1272" points="427 275, 718 242" position="572 258" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1271" /> </Inputs> <Outputs> <Output id="1252" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1273" reactomeId="2395364" points="413 237, 457 225, 523 222" position="457 225" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1271" points="389 266" /> <Input id="1274" points="338 134" /> </Inputs> <Outputs> <Output id="1275" /> </Outputs> <Properties> <displayName>LTBP4 binds TGF-Beta-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1276" reactomeId="2395320" points="995 107, 1057 105, 1115 92" position="1057 105" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1277" points="904 83" /> <Input id="1278" points="984 183" /> </Inputs> <Outputs> <Output id="1279" /> </Outputs> <Properties> <displayName>Latent TGF-beta-1 binds integrins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1281" reactomeId="2396029" points="681 219, 713 202, 749 193" position="713 202" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1282" points="650 88" /> <Input id="817" points="546 357" /> </Inputs> <Outputs> <Output id="1284" /> </Outputs> <Properties> <displayName>Latent TGF-beta-3 binds integrins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="1283" points="729 68, 792 67" position="760 67" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1282" /> </Inputs> <Outputs> <Output id="1277" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="1285" reactomeId="2328033" points="175 249, 177 297, 177 356" position="177 297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1286" points="135 239" /> <Input id="1287" points="187 172" /> </Inputs> <Outputs> <Output id="1290" /> </Outputs> <Properties> <displayName>Fibrillin-1 binds latent TGF-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1288" points="304 126, 223 146" position="263 136" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1274" /> </Inputs> <Outputs> <Output id="1287" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="1289" points="223 162, 785 348" position="504 255" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1287" /> </Inputs> <Outputs> <Output id="1255" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="1291" reactomeId="9748694" points="1237 107, 1329 148, 1394 313" position="1329 148" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1279" /> </Inputs> <Outputs> <Output id="1292" points="1517 111" /> <Output id="6" points="687 429" /> </Outputs> <Activators> <Activator id="1293" points="1327 65" /> <Activator id="1294" points="1393 98" /> </Activators> <Properties> <displayName>Thrombin-, ROCK1- and integrin-mediated release of active TGFB1</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Signaling by TGF-beta Receptor Complex, SMAD4 MH2 Domain Mutants in Cancer, SMAD2/3 Phosphorylation Motif Mutants in Cancer, SMAD2/3 MH2 Domain Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, and TGFBR1 LBD Mutants in Cancer (453316)
