Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of TCR signaling

Class:IdPathwayDiagram:453263
_displayNameDiagram of TCR signaling
_timestamp2019-10-31 13:51:25
created[InstanceEdit:453261] Garapati, P V, 2010-01-20
height1916
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1833530] Jupe, S, 2011-10-26
[InstanceEdit:3604384] Matthews, L, 2013-05-22
[InstanceEdit:6785277] Garapati, Phani Vijay, 2015-06-26
[InstanceEdit:8847699] Orlic-Milacic, Marija, 2015-12-02
[InstanceEdit:8847702] Orlic-Milacic, Marija, 2015-12-02
[InstanceEdit:8852207] Orlic-Milacic, Marija, 2016-01-14
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8855371] Orlic-Milacic, Marija, 2016-02-03
[InstanceEdit:8855372] Orlic-Milacic, Marija, 2016-02-03
[InstanceEdit:8855378] Orlic-Milacic, Marija, 2016-02-03
[InstanceEdit:8855382] Orlic-Milacic, Marija, 2016-02-03
[InstanceEdit:8866033] Garapati, Phani Vijay, 2016-03-29
[InstanceEdit:8870546] Orlic-Milacic, Marija, 2016-05-10
[InstanceEdit:8948117] Orlic-Milacic, Marija, 2016-11-10
[InstanceEdit:8948123] Orlic-Milacic, Marija, 2016-11-10
[InstanceEdit:8948126] Orlic-Milacic, Marija, 2016-11-10
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9665615] Matthews, Lisa, 2019-10-31
representedPathway[Pathway:202403] TCR signaling [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="492" reactomeDiagramId="453263"> <Properties> <displayName>Diagram of TCR signaling</displayName> </Properties> <Nodes> <org.gk.render.RenderableProtein id="1" reactomeId="180494" position="155 89" bounds="108 76 95 27" textPosition="110 79"> <Properties> <displayName>p-Y317-PAG1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1702127659574468" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="180498" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2" reactomeId="203776" position="166 149" bounds="151 138 31 22" textPosition="151 138"> <Properties> <displayName>CSK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3" reactomeId="202297" position="376 89" bounds="340 78 73 22" textPosition="341 79" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Csk:p-PAG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4" reactomeId="202157" position="529 86" bounds="467 61 124 50" textPosition="467 62" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Antigen-bearing MHC Class II : TCR complex:CD4:Lck</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="5" reactomeId="113592" position="619 144" bounds="599 129 40 30" textPosition="604 133" /> <org.gk.render.RenderableChemical id="6" reactomeId="29370" position="774 148" bounds="754 133 41 30" textPosition="758 137" /> <org.gk.render.RenderableComplex id="7" reactomeId="202154" position="844 87" bounds="772 55 144 64" textPosition="773 70" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="8" reactomeId="29356" position="768 189" bounds="747 174 43 30" textPosition="751 178" /> <org.gk.render.RenderableChemical id="11" reactomeId="113592" position="510 218" bounds="490 203 40 30" textPosition="495 207" /> <org.gk.render.RenderableComplex id="12" reactomeId="202266" position="96 266" bounds="37 227 118 78" textPosition="37 228" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="13" reactomeId="29370" position="350 209" bounds="330 194 41 30" textPosition="334 198" /> <org.gk.render.RenderableChemical id="14" reactomeId="113592" position="191 307" bounds="171 292 40 30" textPosition="176 296" /> <org.gk.render.RenderableComplex id="15" reactomeId="203494" position="98 492" bounds="33 453 130 78" textPosition="32 468" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="16" reactomeId="29370" position="202 468" bounds="182 453 41 30" textPosition="186 457" /> <org.gk.render.RenderableProtein id="17" reactomeId="202397" position="180 556" bounds="155 545 50 22" textPosition="157 545"> <Properties> <displayName>ZAP70</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="18" reactomeId="202330" position="104 662" bounds="47 637 114 50" textPosition="47 638" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ZAP-70 bound to phosphorylated ITAM motifs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="19" reactomeId="113592" position="186 690" bounds="166 678 40 25" textPosition="171 680" /> <org.gk.render.RenderableComplex id="20" reactomeId="202345" position="96 926" bounds="40 908 112 36" textPosition="39 909" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phospho tyrosine ZAP-70</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="21" reactomeId="29370" position="203 891" bounds="183 876 41 30" textPosition="187 880" /> <org.gk.render.RenderableChemical id="22" reactomeId="113592" position="206 941" bounds="186 926 40 30" textPosition="191 930" /> <org.gk.render.RenderableComplex id="23" reactomeId="202181" position="105 1206" bounds="47 1195 116 22" textPosition="50 1196" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Activated ZAP-70</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="24" reactomeId="29370" position="207 1128" bounds="187 1113 41 30" textPosition="191 1117" /> <org.gk.render.RenderableProtein id="26" reactomeId="202322" position="95 1256" bounds="80 1245 31 22" textPosition="80 1245"> <Properties> <displayName>LAT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="27" reactomeId="202364" position="96 1442" bounds="57 1425 79 34" textPosition="63 1431"> <Properties> <displayName>p-5Y-LAT</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.3670886075949367" relativeY="1.0" label="P" description="Tyr" trackId="0" reactomeId="202242" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.5588235294117647" label="P" description="Tyr" trackId="0" reactomeId="202363" /> <org.gk.render.RenderableFeature relativeX="0.25316455696202533" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="202351" /> <org.gk.render.RenderableFeature relativeX="0.6329113924050633" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="202286" /> <org.gk.render.RenderableFeature relativeX="0.7647058823529411" relativeY="1.0" label="P" description="Tyr" trackId="1" reactomeId="2396546" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="29" reactomeId="202367" position="168 1471" bounds="144 1460 49 22" textPosition="145 1460"> <Properties> <displayName>GRAP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="30" reactomeId="202177" position="97 1604" bounds="45 1593 104 22" textPosition="45 1594" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GADS:p-5Y-LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="31" reactomeId="202306" position="215 1634" bounds="196 1623 38 22" textPosition="196 1623"> <Properties> <displayName>LCP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="32" reactomeId="202151" position="158 1808" bounds="103 1790 111 36" textPosition="103 1791" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SLP-76 bound to Gads:LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="33" reactomeId="70101" position="1673 950" bounds="90 83 3166 1734" textPosition="615 1441" bgColor="250 240 240" lineColor="255 153 102" insets="100 93 3146 1714"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="1" /> <Component id="2" /> <Component id="3" /> <Component id="11" /> <Component id="12" /> <Component id="13" /> <Component id="69" /> <Component id="72" /> <Component id="73" /> <Component id="14" /> <Component id="4" /> <Component id="5" /> <Component id="6" /> <Component id="7" /> <Component id="15" /> <Component id="16" /> <Component id="70" /> <Component id="71" /> <Component id="74" /> <Component id="17" /> <Component id="18" /> <Component id="19" /> <Component id="8" /> <Component id="20" /> <Component id="21" /> <Component id="76" /> <Component id="22" /> <Component id="23" /> <Component id="24" /> <Component id="77" /> <Component id="26" /> <Component id="27" /> <Component id="78" /> <Component id="29" /> <Component id="30" /> <Component id="79" /> <Component id="31" /> <Component id="32" /> <Component id="80" /> <Component id="34" /> <Component id="35" /> <Component id="36" /> <Component id="81" /> <Component id="38" /> <Component id="37" /> <Component id="82" /> <Component id="39" /> <Component id="40" /> <Component id="41" /> <Component id="84" /> <Component id="42" /> <Component id="43" /> <Component id="44" /> <Component id="45" /> <Component id="46" /> <Component id="85" /> <Component id="47" /> <Component id="48" /> <Component id="49" /> <Component id="50" /> <Component id="51" /> <Component id="88" /> <Component id="52" /> <Component id="53" /> <Component id="89" /> <Component id="55" /> <Component id="56" /> <Component id="57" /> <Component id="90" /> <Component id="59" /> <Component id="60" /> <Component id="91" /> <Component id="61" /> <Component id="62" /> <Component id="93" /> <Component id="64" /> <Component id="65" /> <Component id="66" /> <Component id="94" /> <Component id="67" /> <Component id="68" /> <Component id="95" /> <Component id="96" /> <Component id="99" /> <Component id="100" /> <Component id="101" /> <Component id="102" /> <Component id="103" /> <Component id="104" /> <Component id="105" /> <Component id="106" /> <Component id="107" /> <Component id="108" /> <Component id="109" /> <Component id="110" /> <Component id="111" /> <Component id="112" /> <Component id="113" /> <Component id="114" /> <Component id="115" /> <Component id="116" /> <Component id="117" /> <Component id="118" /> <Component id="119" /> <Component id="120" /> <Component id="121" /> <Component id="122" /> <Component id="123" /> <Component id="124" /> <Component id="125" /> <Component id="126" /> <Component id="127" /> <Component id="128" /> <Component id="129" /> <Component id="130" /> <Component id="131" /> <Component id="132" /> <Component id="133" /> <Component id="134" /> <Component id="135" /> <Component id="136" /> <Component id="137" /> <Component id="138" /> <Component id="140" /> <Component id="141" /> <Component id="142" /> <Component id="143" /> <Component id="144" /> <Component id="145" /> <Component id="149" /> <Component id="147" /> <Component id="146" /> <Component id="148" /> <Component id="150" /> <Component id="151" /> <Component id="152" /> <Component id="153" /> <Component id="155" /> <Component id="156" /> <Component id="157" /> <Component id="225" /> <Component id="226" /> <Component id="274" /> <Component id="275" /> <Component id="276" /> <Component id="277" /> <Component id="278" /> <Component id="279" /> <Component id="280" /> <Component id="281" /> <Component id="282" /> <Component id="283" /> <Component id="284" /> <Component id="285" /> <Component id="286" /> <Component id="287" /> <Component id="288" /> <Component id="289" /> <Component id="290" /> <Component id="291" /> <Component id="292" /> <Component id="294" /> <Component id="298" /> <Component id="75" /> <Component id="300" /> <Component id="304" /> <Component id="306" /> <Component id="305" /> <Component id="364" /> <Component id="365" /> <Component id="366" /> <Component id="368" /> <Component id="367" /> <Component id="369" /> <Component id="384" /> <Component id="385" /> <Component id="370" /> <Component id="386" /> <Component id="397" /> <Component id="398" /> <Component id="399" /> <Component id="400" /> <Component id="406" /> <Component id="407" /> <Component id="408" /> <Component id="424" /> <Component id="425" /> <Component id="442" /> <Component id="443" /> <Component id="445" /> <Component id="446" /> <Component id="447" /> <Component id="452" /> <Component id="455" /> <Component id="456" /> <Component id="481" /> <Component id="482" /> <Component id="483" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="34" reactomeId="202162" position="417 1804" bounds="352 1783 131 43" textPosition="361 1791" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y113,128,145-SLP-76:GADS:LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="35" reactomeId="113592" position="204 1710" bounds="184 1695 40 30" textPosition="189 1699" /> <org.gk.render.RenderableChemical id="36" reactomeId="29370" position="405 1722" bounds="385 1707 41 30" textPosition="389 1711" /> <org.gk.render.RenderableProtein id="37" reactomeId="202319" position="500 1767" bounds="479 1754 42 26" textPosition="486 1756"> <Properties> <displayName>ITK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="38" reactomeId="202359" position="620 1811" bounds="571 1786 98 50" textPosition="575 1787" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ITK:p-Y113,128,145-SLP-76:GADS:LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="39" reactomeId="202320" position="407 1667" bounds="384 1656 47 22" textPosition="385 1656"> <Properties> <displayName>PLCG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="40" reactomeId="202279" position="750 1806" bounds="693 1788 114 36" textPosition="694 1789" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PLCG1:p-3Y-SLP-76:Gads:LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="41" reactomeId="202240" position="89 1756" bounds="34 1745 110 22" textPosition="35 1746" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PLCG1:p-5Y-LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="42" reactomeId="202318" position="918 1807" bounds="852 1789 133 36" textPosition="852 1789" bgColor="204 255 255"> <Properties> <displayName>PLC-gamma1 bound to LAT or SLP-76</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="43" reactomeId="113592" position="1012 1731" bounds="992 1716 40 30" textPosition="997 1720" /> <org.gk.render.RenderableEntitySet id="44" reactomeId="202193" position="1246 1798" bounds="1181 1766 130 64" textPosition="1180 1773" bgColor="204 255 255"> <Properties> <displayName>Phosphorylated PLC-gamma1 bound to LAT or SLP-76</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="45" reactomeId="29370" position="1191 1734" bounds="1171 1719 41 30" textPosition="1175 1723" /> <org.gk.render.RenderableEntitySet id="46" reactomeId="202282" position="1091 1828" bounds="1036 1810 111 36" textPosition="1039 1810"> <Properties> <displayName>ZAP-70 and ITK tyrosine kinases</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="47" reactomeId="202310" position="1846 1809" bounds="1781 1784 131 50" textPosition="1781 1785" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phosphorylated PLC-gamma1 bound to LAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="48" reactomeId="202357" position="2041 1816" bounds="1986 1791 111 51" textPosition="1996 1799"> <Properties> <displayName>p-Y771,Y783,Y1254-PLCG1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.22522522522522523" relativeY="0.9607843137254902" label="P" description="Tyr" trackId="0" reactomeId="167675" /> <org.gk.render.RenderableFeature relativeX="0.3404255319148936" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="191478" /> <org.gk.render.RenderableFeature relativeX="0.5106382978723404" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="191469" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="49" reactomeId="202302" position="1652 1802" bounds="1587 1777 131 50" textPosition="1587 1778" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phosphorylated PLC-gamma1 bound to SLP-76</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="50" reactomeId="179856" position="2183 1809" bounds="2148 1794 70 30" textPosition="2153 1798"> <Properties> <displayName>PI(4,5)P2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="51" reactomeId="202269" position="2347 1815" bounds="2287 1790 120 50" textPosition="2287 1791" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Activated PLC gamma1 bound to PIP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="52" reactomeId="29356" position="2200 1720" bounds="2179 1705 43 30" textPosition="2183 1709" /> <org.gk.render.RenderableChemical id="53" reactomeId="112275" position="2535 1807" bounds="2511 1792 49 30" textPosition="2515 1796" /> <org.gk.render.RenderableProtein id="55" reactomeId="202201" position="3252 1763" bounds="3188 1738 128 51" textPosition="3196 1746"> <Properties> <displayName>p-Y63,Y79,Y110-TRAT1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.125" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="202257" /> <org.gk.render.RenderableFeature relativeX="0.25" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="202158" /> <org.gk.render.RenderableFeature relativeX="0.375" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="202299" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="56" reactomeId="74693" position="3147 1729" bounds="3130 1718 35 22" textPosition="3131 1719" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="57" reactomeId="202283" position="3251 1647" bounds="3186 1636 130 22" textPosition="3188 1637" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PI3K bound to TRAT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="59" reactomeId="179838" position="3254 1458" bounds="3213 1443 82 30" textPosition="3219 1447"> <Properties> <displayName>PI(3,4,5)P3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="60" reactomeId="29370" position="3179 1490" bounds="3159 1475 41 30" textPosition="3163 1479" /> <org.gk.render.RenderableChemical id="61" reactomeId="202247" position="3253 1271" bounds="3218 1256 70 30" textPosition="3223 1260"> <Properties> <displayName>PI(3,4)P2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="62" reactomeId="197940" position="3184 1373" bounds="3157 1362 54 22" textPosition="3159 1362"> <Properties> <displayName>INPP5D</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="64" reactomeId="202277" position="3253 1134" bounds="3203 1123 101 22" textPosition="3208 1123"> <Properties> <displayName>PIP3, PI(3,4)P2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="65" reactomeId="202210" position="3149 1134" bounds="3125 1123 48 22" textPosition="3126 1123"> <Properties> <displayName>PDPK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="66" reactomeId="202311" position="3254 949" bounds="3203 938 103 22" textPosition="3207 939" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PDK1:PIP2,PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="67" reactomeId="202185" position="3138 890" bounds="3091 872 94 36" textPosition="3091 872"> <Properties> <displayName>PRKQC closed conformation</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="68" reactomeId="202187" position="3243 781" bounds="3185 763 117 36" textPosition="3185 764" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PKC-theta (open): DAG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="95" reactomeId="179856" position="3249 1586" bounds="3214 1571 70 30" textPosition="3219 1575" /> <org.gk.render.RenderableChemical id="96" reactomeId="113592" position="3179 1584" bounds="3159 1569 40 30" textPosition="3164 1573" /> <org.gk.render.RenderableChemical id="99" reactomeId="179856" position="3253 1218" bounds="3218 1203 70 30" textPosition="3223 1207" /> <org.gk.render.RenderableChemical id="100" reactomeId="112275" position="3255 897" bounds="3231 882 49 30" textPosition="3235 886"> <Properties> <displayName>DAGs</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="102" reactomeId="113592" position="3110 785" bounds="3090 770 40 30" textPosition="3095 774" /> <org.gk.render.RenderableComplex id="103" reactomeId="202300" position="3251 620" bounds="3193 602 117 36" textPosition="3194 603" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y90-PKC-theta:DAG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="104" reactomeId="29370" position="3099 629" bounds="3079 614 41 30" textPosition="3083 618" /> <org.gk.render.RenderableComplex id="105" reactomeId="202266" position="3253 700" bounds="3194 661 118 78" textPosition="3194 662" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="107" reactomeId="113592" position="3154 597" bounds="3134 582 40 30" textPosition="3139 586" /> <org.gk.render.RenderableComplex id="108" reactomeId="202442" position="3253 477" bounds="3196 459 115 36" textPosition="3200 460" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Active PKC theta bound to DAG</displayName> </Properties> <OldBounds> <Bounds id="108" bounds="3317 494 116 70" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="109" reactomeId="29370" position="3153 487" bounds="3133 472 41 30" textPosition="3137 476" /> <org.gk.render.RenderableProtein id="111" reactomeId="202161" position="3011 961" bounds="2982 950 58 22" textPosition="2983 950"> <Properties> <displayName>CARD11</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="112" reactomeId="202349" position="3252 413" bounds="3193 395 119 36" textPosition="3193 396" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CARMA1 bound to PDK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="114" reactomeId="113592" position="3171 380" bounds="3151 365 40 30" textPosition="3156 369" /> <org.gk.render.RenderableChemical id="115" reactomeId="29370" position="3174 297" bounds="3154 282 41 30" textPosition="3158 286" /> <org.gk.render.RenderableComplex id="116" reactomeId="202440" position="3252 264" bounds="3192 253 121 22" textPosition="3194 254" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Activated CARMA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="118" reactomeId="202438" position="3123 242" bounds="3065 225 117 35" textPosition="3070 232"> <Properties> <displayName>p-S552-CARD11</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.4700854700854701" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="202441" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="119" reactomeId="202445" position="3252 92" bounds="3202 81 100 22" textPosition="3203 82" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CARMA1 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="121" reactomeId="202447" position="3186 130" bounds="3163 119 46 22" textPosition="3163 119"> <Properties> <displayName>BCL10</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="122" reactomeId="202454" position="3081 90" bounds="3031 72 101 36" textPosition="3031 73" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Bcl10 bound to CARMA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="124" reactomeId="113592" position="3060 152" bounds="3040 137 40 30" textPosition="3045 141" /> <org.gk.render.RenderableChemical id="125" reactomeId="29370" position="2911 152" bounds="2891 137 41 30" textPosition="2895 141" /> <org.gk.render.RenderableComplex id="126" reactomeId="202480" position="2861 90" bounds="2802 65 118 50" textPosition="2804 66" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Phosphorylated Bcl10 bound to CARMA1 and RIP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="127" reactomeId="168402" position="2986 154" bounds="2965 143 43 22" textPosition="2966 143"> <Properties> <displayName>RIPK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="129" reactomeId="202488" position="2806 155" bounds="2768 141 76 29" textPosition="2776 145"> <Properties> <displayName>p-BCL10</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.26229508196721313" relativeY="0.0" label="P" trackId="0" reactomeId="202457" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="130" reactomeId="202475" position="2665 88" bounds="2599 70 132 36" textPosition="2603 71" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Bcl10 trimer bound to CARMA1 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="132" reactomeId="202487" position="2633 144" bounds="2589 133 88 22" textPosition="2589 134" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MALT1 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="133" reactomeId="202468" position="2441 90" bounds="2375 65 133 50" textPosition="2375 66" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MALT1 trimer bound to Bcl10 and CARMA1 trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="135" reactomeId="166366" position="2383 149" bounds="2360 138 47 22" textPosition="2361 138"> <Properties> <displayName>TRAF6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="136" reactomeId="202471" position="2224 91" bounds="2159 73 131 36" textPosition="2159 74" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TRAF6 trimer bound to CBM complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="138" reactomeId="202463" position="2067 180" bounds="2016 169 102 22" textPosition="2019 170" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="140" reactomeId="202456" position="1971 89" bounds="1915 64 113 50" textPosition="1915 65" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ub-TRAF6 trimer bound to CBM complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="142" reactomeId="202504" position="1892 197" bounds="1827 186 131 22" textPosition="1827 187" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TAB2/TAK1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="143" reactomeId="113592" position="1920 151" bounds="1900 136 40 30" textPosition="1905 140" /> <org.gk.render.RenderableComplex id="144" reactomeId="202507" position="1700 89" bounds="1633 64 135 50" textPosition="1633 65" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TAK1/TAB2 complex bound to TRAF6/CBM complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="145" reactomeId="29370" position="1766 155" bounds="1746 140 41 30" textPosition="1750 144" /> <org.gk.render.RenderableComplex id="147" reactomeId="168113" position="1696 255" bounds="1637 244 118 22" textPosition="1654 231" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHUK:IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="148" reactomeId="113592" position="1690 159" bounds="1670 144 40 30" textPosition="1675 148" /> <org.gk.render.RenderableComplex id="149" reactomeId="202513" position="1504 263" bounds="1442 245 125 36" textPosition="1443 246" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S177,S181-IKKB:IKKA:NEMO</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="150" reactomeId="29370" position="1508 162" bounds="1488 147 41 30" textPosition="1492 151" /> <org.gk.render.RenderableComplex id="152" reactomeId="202562" position="1871 419" bounds="1809 401 125 36" textPosition="1810 402" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S177,S181-IKKB:IKKA:pUb-NEMO</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="153" reactomeId="202463" position="1609 408" bounds="1558 397 102 22" textPosition="1561 398" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UBE2N:UBE2V1</displayName> </Properties> <OldBounds> <Bounds id="462" bounds="2758 524 95 57" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="156" reactomeId="193938" position="1960 571" bounds="1905 553 110 36" textPosition="1905 554" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IkB(alpha):NF-kB complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="157" reactomeId="113592" position="1966 637" bounds="1946 622 40 30" textPosition="1951 626" /> <org.gk.render.RenderableChemical id="225" reactomeId="29372" position="626 185" bounds="613 170 27 30" textPosition="617 174" /> <org.gk.render.RenderableEntity id="226" reactomeId="450152" position="2203 180" bounds="2167 169 73 22" textPosition="2167 169"> <Properties> <displayName>K63polyUb</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntity id="274" reactomeId="450152" position="1575 347" bounds="1539 336 73 22" textPosition="1539 336" /> <org.gk.render.RenderableProtein id="276" reactomeId="202175" position="1069 1176" bounds="1020 1153 99 46" textPosition="1023 1158"> <Properties> <displayName>p-Y113,128,145-LCP2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16161616161616163" relativeY="0.0" label="P" trackId="0" reactomeId="202342" /> <org.gk.render.RenderableFeature relativeX="0.32323232323232326" relativeY="0.0" label="P" trackId="0" reactomeId="202399" /> <org.gk.render.RenderableFeature relativeX="0.48484848484848486" relativeY="0.0" label="P" trackId="0" reactomeId="202382" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="277" reactomeId="390925" position="977 1170" bounds="962 1159 31 22" textPosition="963 1159"> <Properties> <displayName>FYB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="278" reactomeId="430124" position="1018 1060" bounds="967 1049 102 22" textPosition="968 1050" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-SLP-76:ADAP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="280" reactomeId="430213" position="893 1060" bounds="831 1049 125 22" textPosition="835 1049"> <Properties> <displayName>Ena/VASP proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="281" reactomeId="430206" position="960 906" bounds="907 888 106 36" textPosition="908 889" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-SLP-76:ADAP:Ena/VASP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="283" reactomeId="197954" position="1184 1170" bounds="1163 1159 42 22" textPosition="1163 1159"> <Properties> <displayName>NCK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="284" reactomeId="430188" position="1145 1060" bounds="1094 1049 103 22" textPosition="1095 1050" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-SLP-76:NCK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="286" reactomeId="390765" position="1235 1061" bounds="1203 1050 64 22" textPosition="1204 1050"> <Properties> <displayName>PAK1,2,3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="287" reactomeId="430189" position="1183 947" bounds="1122 936 122 22" textPosition="1123 937" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-SLP-76:NCK:PAK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="289" reactomeId="201879" position="1069 977" bounds="1051 966 36 22" textPosition="1052 966"> <Properties> <displayName>WAS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="290" reactomeId="430186" position="1091 815" bounds="1038 797 107 36" textPosition="1039 798" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-SLP-76:NCK1:WASP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="291" reactomeId="114520" position="2515 1681" bounds="2478 1666 75 30" textPosition="2483 1670"> <Properties> <displayName>I(1,4,5)P3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="300" reactomeId="113592" position="150 1280" bounds="130 1265 40 30" textPosition="135 1269"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="304" reactomeId="29370" position="159 1407" bounds="139 1392 41 30" textPosition="143 1396"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="305" reactomeId="5607671" position="1763 658" bounds="1715 633 97 50" textPosition="1716 634" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S32,36-IkB-alpha:NF-kB complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="306" reactomeId="29370" position="1779 577" bounds="1759 562 41 30" textPosition="1763 566" /> <org.gk.render.RenderableEntitySet id="365" reactomeId="5607669" position="1639 741" bounds="1581 723 117 36" textPosition="1585 723"> <Properties> <displayName>UBE2D2,UBE2D1,(CDC34)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="366" reactomeId="912722" position="1756 737" bounds="1728 726 56 22" textPosition="1729 726"> <Properties> <displayName>K48-Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="367" reactomeId="5607687" position="1644 580" bounds="1594 569 100 22" textPosition="1595 570" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SCF-beta-TRCP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="368" reactomeId="5607697" position="1494 658" bounds="1429 633 130 50" textPosition="1430 634" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="370" reactomeId="194043" position="1291 660" bounds="1228 649 127 22" textPosition="1229 650" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NFKB1(1-433):RELA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="383" reactomeId="194047" position="1082 659" bounds="1019 648 127 22" textPosition="1020 649" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="384" reactomeId="68819" position="1387 536" bounds="1331 525 113 22" textPosition="1336 526" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>26S proteasome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="385" reactomeId="7660" position="1111 662" bounds="998 585 226 155" textPosition="1068 671" bgColor="250 240 240" lineColor="255 153 102" insets="1008 596 207 134"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="382" /> <Component id="383" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="386" reactomeId="6785270" position="978 88" bounds="935 77 87 22" textPosition="936 77"> <Properties> <displayName>CD45,CD148</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="398" reactomeId="1806240" position="2709 1814" bounds="2686 1799 47 30" textPosition="2693 1803"> <Properties> <displayName>PI5P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="399" reactomeId="6811458" position="2779 1663" bounds="2729 1645 101 37" textPosition="2735 1646"> <Properties> <displayName>DOK1,DOK2,DOK5,(DOK4)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="400" reactomeId="6811483" position="2859 1804" bounds="2800 1787 118 35" textPosition="2803 1787" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PI5P:DOK1,DOK2,DOK5,(DOK4)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="407" reactomeId="29356" position="322 339" bounds="302 327 41 24" textPosition="305 328" /> <org.gk.render.RenderableProtein id="408" reactomeId="8852205" position="410 416" bounds="379 404 63 24" textPosition="384 405"> <Properties> <displayName>PTPN22</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="425" reactomeId="8855376" position="268 433" bounds="236 416 65 34" textPosition="240 415" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PTPN22:CSK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="443" reactomeId="29356" position="216 836" bounds="195 821 43 30" textPosition="199 825"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="445" reactomeId="29372" position="244 715" bounds="227 702 34 26" textPosition="235 704" /> <org.gk.render.RenderableProtein id="446" reactomeId="8866028" position="1088 1646" bounds="1063 1635 50 22" textPosition="1064 1635"> <Properties> <displayName>CD101</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="447" reactomeId="199420" position="3034 1372" bounds="3014 1361 40 22" textPosition="3015 1361"> <Properties> <displayName>PTEN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="455" reactomeId="29372" position="3190 1280" bounds="3177 1265 27 30" textPosition="3181 1269"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="456" reactomeId="29356" position="3204 1427" bounds="3186 1413 37 28" textPosition="3187 1416" /> <org.gk.render.ProcessNode id="481" reactomeId="1257604" position="3020 1482" bounds="2952 1454 137 56" textPosition="2957 1460"> <Properties> <displayName>PIP3 activates AKT signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="483" reactomeId="2029095" position="2465 1813" bounds="2439 1802 53 22" textPosition="2439 1802" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="69" reactomeId="203774" points="248 89, 270 89, 337 89" position="270 89" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1" points="206 89" /> <Input id="2" points="181 135" /> </Inputs> <Outputs> <Output id="3" /> </Outputs> <Properties> <displayName>Interaction of Csk with PAG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="70" reactomeId="202233" points="660 86, 695 86, 728 86" position="695 86" lineWidth="1.0"> <Inputs> <Input id="4" points="594 86" /> <Input id="5" points="629 126" /> </Inputs> <Outputs> <Output id="6" points="762 130" /> <Output id="7" points="769 86" /> </Outputs> <Catalysts> <Catalyst id="3" points="387 75, 439 28, 695 28" /> </Catalysts> <Inhibitors> <Inhibitor id="386" points="958 71, 847 15" /> </Inhibitors> <Properties> <displayName>Inactivation of Lck by Csk</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="202214" points="823 232, 711 255, 571 234" position="711 255" lineWidth="1.0"> <Inputs> <Input id="8" points="787 207" /> <Input id="7" points="839 122" /> </Inputs> <Outputs> <Output id="225" points="610 197" /> <Output id="4" points="536 114" /> </Outputs> <Catalysts> <Catalyst id="386" points="973 105, 887 301, 711 301" /> </Catalysts> <Properties> <displayName>Dephosphorylation of Lck-pY505 by CD45</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="72" reactomeId="202291" points="471 197, 447 265, 408 265, 376 265" position="408 265" lineWidth="1.0"> <Inputs> <Input id="4" points="515 114" /> <Input id="11" points="487 207" /> </Inputs> <Outputs> <Output id="12" points="158 265" /> <Output id="13" points="356 227" /> </Outputs> <Catalysts> <Catalyst id="4" points="464 106, 408 126" /> </Catalysts> <Properties> <displayName>Activation of Lck</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="73" reactomeId="202165" points="142 348, 142 380, 142 415" position="142 380" lineWidth="1.0"> <Inputs> <Input id="12" points="117 308" /> <Input id="14" stoichiometry="20" points="173 325" /> </Inputs> <Outputs> <Output id="15" points="120 450" /> <Output id="16" stoichiometry="20" points="185 450" /> </Outputs> <Catalysts> <Catalyst id="12" points="101 308, 113 379" /> </Catalysts> <Properties> <displayName>Phosphorylation of ITAM motifs in CD3 complexes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="74" reactomeId="202344" points="115 549, 115 591, 107 634" position="115 591" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" points="109 534" /> <Input id="17" points="152 553" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Properties> <displayName>Recruitment of ZAP-70 to phosphorylated ITAMs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="202168" points="147 727, 146 766, 147 799" position="146 766" lineWidth="1.0"> <Inputs> <Input id="18" points="120 690" /> <Input id="19" points="172 706" /> </Inputs> <Outputs> <Output id="20" points="103 905" /> <Output id="21" points="193 873" /> </Outputs> <Catalysts> <Catalyst id="12" points="60 308, 18 352, 22 767" /> </Catalysts> <Properties> <displayName>Phosphorylation of ZAP-70 by Lck</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="202174" points="142 982, 142 1020, 142 1104" position="142 1020" lineWidth="1.0"> <Inputs> <Input id="20" points="110 947" /> <Input id="22" points="183 953" /> </Inputs> <Outputs> <Output id="23" points="108 1192" /> <Output id="24" points="184 1120" /> </Outputs> <Catalysts> <Catalyst id="20" points="98 947, 109 1019" /> </Catalysts> <Properties> <displayName>Activation of ZAP-70</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="202245" points="95 1301, 95 1328, 95 1358" position="95 1328" lineWidth="1.0"> <Inputs> <Input id="300" stoichiometry="5" points="127 1287" /> <Input id="26" points="95 1270" /> </Inputs> <Outputs> <Output id="27" points="95 1422" /> <Output id="304" stoichiometry="5" points="139 1389" /> </Outputs> <Catalysts> <Catalyst id="23" points="44 1205, 15 1205, 47 1327" /> </Catalysts> <Properties> <displayName>Phosphorylation of TBSMs in LAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="202325" points="96 1500, 96 1535, 96 1590" position="96 1535" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="141 1480" /> <Input id="27" points="96 1462" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>Recruitment of Gads to LAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="202241" points="157 1682, 157 1713, 157 1787" position="157 1713" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="31" points="201 1648" /> <Input id="30" points="105 1618" /> </Inputs> <Outputs> <Output id="32" /> </Outputs> <Properties> <displayName>Recruitment of SLP-76 to Gads</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="202216" points="256 1752, 312 1752, 347 1752" position="312 1752" lineWidth="1.0"> <Inputs> <Input id="35" stoichiometry="3" points="222 1728" /> <Input id="32" points="189 1787" /> </Inputs> <Outputs> <Output id="34" points="388 1780" /> <Output id="36" stoichiometry="3" points="382 1732" /> </Outputs> <Catalysts> <Catalyst id="23" points="120 1220, 311 1356" /> </Catalysts> <Properties> <displayName>Phosphorylation of SLP-76</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="81" reactomeId="202375" points="516 1803, 538 1803, 568 1806" position="538 1803" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="34" points="486 1803" /> <Input id="37" points="505 1783" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> <Properties> <displayName>Recruitment of ITK to SLP-76</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="202331" points="472 1730, 663 1725, 730 1785" position="663 1725" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="34" points="432 1780" /> <Input id="39" points="418 1681" /> </Inputs> <Outputs> <Output id="40" /> </Outputs> <Properties> <displayName>Recruitment of PLC-gamma1 to SLP-76</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="202212" points="33 1552, 33 1645, 83 1742" position="33 1645" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="27" points="86 1462" /> <Input id="39" points="381 1659" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Properties> <displayName>Recruitment of PLC-gamma1 to LAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="202248" points="1068 1763, 1090 1763, 1115 1763" position="1090 1763" lineWidth="1.0"> <Inputs> <Input id="42" points="979 1783" /> <Input id="43" stoichiometry="3" points="1035 1742" /> </Inputs> <Outputs> <Output id="44" points="1175 1780" /> <Output id="45" stoichiometry="3" points="1168 1741" /> </Outputs> <Catalysts> <Catalyst id="46" points="1090 1804" /> </Catalysts> <Inhibitors> <Inhibitor id="446" points="1088 1660" /> </Inhibitors> <Properties> <displayName>Phosphorylation of PLC-gamma1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="213406" points="1884 1781, 1930 1754, 1949 1719" position="1930 1754" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="47" /> </Inputs> <Outputs> <Output id="48" points="2016 1788" /> <Output id="27" points="139 1447" /> </Outputs> <Properties> <displayName>Disassociation of PLC-gamma1 from LAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="213407" points="1704 1830, 1760 1853, 1861 1887" position="1760 1853" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="49" /> </Inputs> <Outputs> <Output id="48" points="1983 1837" /> <Output id="34" points="450 1829, 566 1900" /> </Outputs> <Properties> <displayName>Disassociation of PLC-gamma1 from SLP-76</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="202354" points="2203 1847, 2252 1848, 2284 1835" position="2252 1848" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="50" points="2190 1827" /> <Input id="48" points="2100 1826" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Properties> <displayName>Translocation of PLC-gamma1 to PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="202407" points="2231 1740, 2394 1741, 2445 1741" position="2394 1741" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="50" points="2193 1791" /> <Input id="52" points="2225 1733" /> </Inputs> <Outputs> <Output id="53" points="2514 1789" /> <Output id="291" points="2497 1699" /> </Outputs> <Catalysts> <Catalyst id="483" points="2454 1796" /> </Catalysts> <Properties> <displayName>PLC-gamma1 hydrolyses PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="202203" points="3252 1712, 3251 1689, 3251 1661" position="3251 1689" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="55" points="3252 1735" /> <Input id="56" points="3168 1726" /> </Inputs> <Outputs> <Output id="57" /> </Outputs> <Properties> <displayName>Recruitment of PI3K to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="202365" points="3216 1557, 3217 1530, 3217 1507" position="3217 1530" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="96" points="3202 1569" /> <Input id="95" points="3231 1568" /> </Inputs> <Outputs> <Output id="59" points="3242 1476" /> <Output id="60" points="3203 1499" /> </Outputs> <Catalysts> <Catalyst id="57" points="3262 1633, 3293 1608, 3292 1528" /> </Catalysts> <Properties> <displayName>PI3K bound to TRAT1 phosphorylates PIP2 to PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="91" reactomeId="202237" points="3253 1411, 3253 1372, 3253 1336" position="3253 1372" lineWidth="1.0"> <Inputs> <Input id="456" points="3226 1420" /> <Input id="59" points="3253 1440" /> </Inputs> <Outputs> <Output id="61" points="3253 1289" /> <Output id="455" points="3207 1292" /> </Outputs> <Catalysts> <Catalyst id="62" points="3214 1372" /> </Catalysts> <Properties> <displayName>Hydrolysis of PIP3 to PI(3,4)P2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="93" reactomeId="202164" points="3221 1101, 3221 1079, 3251 963" position="3221 1079" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="64" points="3242 1117" /> <Input id="65" points="3173 1120" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Properties> <displayName>Translocation of PDK1 to Plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="94" reactomeId="202328" points="3233 861, 3233 834, 3239 802" position="3233 834" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="67" points="3188 875" /> <Input id="100" points="3245 879" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> <Properties> <displayName>Translocation of PKC theta to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="202307" points="3136 753, 3136 702, 3136 664" position="3136 702" lineWidth="1.0"> <Inputs> <Input id="68" points="3182 765" /> <Input id="102" points="3122 767" /> </Inputs> <Outputs> <Output id="103" points="3203 641" /> <Output id="104" points="3114 647" /> </Outputs> <Catalysts> <Catalyst id="105" points="3191 701" /> </Catalysts> <Properties> <displayName>Change of PKC theta conformation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="202222" points="3227 571, 3227 547, 3227 519" position="3227 547" lineWidth="1.0"> <Inputs> <Input id="103" points="3242 599" /> <Input id="107" stoichiometry="3" points="3177 589" /> </Inputs> <Outputs> <Output id="108" points="3241 498" /> <Output id="109" stoichiometry="3" points="3177 495" /> </Outputs> <Catalysts> <Catalyst id="66" points="3270 935, 3332 898, 3329 544" /> </Catalysts> <Properties> <displayName>Phosphorylation of PKC theta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="202394" points="3038 920, 3040 477, 3190 430" position="3040 477" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="66" points="3200 942" /> <Input id="111" points="3018 947" /> </Inputs> <Outputs> <Output id="112" /> </Outputs> <Properties> <displayName>Translocation of CARMA1 to Plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="202437" points="3251 368, 3251 344, 3251 322" position="3251 344" lineWidth="1.0"> <Inputs> <Input id="112" points="3251 392" /> <Input id="114" points="3194 377" /> </Inputs> <Outputs> <Output id="115" points="3198 303" /> <Output id="116" points="3251 278" /> </Outputs> <Catalysts> <Catalyst id="108" points="3314 477, 3333 477, 3333 343" /> </Catalysts> <Properties> <displayName>Phosphorylation of CARMA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="202443" points="3216 216, 3223 188, 3248 106" position="3223 188" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="118" stoichiometry="2" points="3185 225" /> <Input id="116" points="3243 250" /> </Inputs> <Outputs> <Output id="119" /> </Outputs> <Properties> <displayName>Oligomerization of CARMA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="120" reactomeId="202466" points="3185 89, 3169 89, 3135 89" position="3169 89" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="119" points="3199 89" /> <Input id="121" points="3185 116" /> </Inputs> <Outputs> <Output id="122" /> </Outputs> <Properties> <displayName>Interaction of Bcl10 to CARMA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="202459" points="3010 90, 2985 90, 2967 90" position="2985 90" lineWidth="1.0"> <Inputs> <Input id="122" points="3028 90" /> <Input id="124" points="3047 134" /> </Inputs> <Outputs> <Output id="125" points="2924 134" /> <Output id="126" points="2923 90" /> </Outputs> <Catalysts> <Catalyst id="127" points="2985 140" /> </Catalysts> <Properties> <displayName>Phosphorylation of Bcl10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="128" reactomeId="202489" points="2782 88, 2760 88, 2734 88" position="2760 88" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="129" stoichiometry="2" points="2800 138" /> <Input id="126" points="2799 88" /> </Inputs> <Outputs> <Output id="130" /> </Outputs> <Properties> <displayName>Oligomerization of Bcl10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="202478" points="2578 88, 2549 88, 2511 88" position="2549 88" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="130" points="2596 88" /> <Input id="132" points="2622 130" /> </Inputs> <Outputs> <Output id="133" /> </Outputs> <Properties> <displayName>Interaction and oligomerization of MALT1 to Bcl10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="202472" points="2347 89, 2322 89, 2293 89" position="2322 89" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="133" points="2372 89" /> <Input id="135" stoichiometry="3" points="2376 135" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>Translocation of TRAF6 to CBM complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="137" reactomeId="202453" points="2132 89, 2093 89, 2067 89" position="2093 89" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="136" points="2156 89" /> <Input id="138" stoichiometry="3" points="2074 166" /> <Input id="226" stoichiometry="3" points="2194 166" /> </Inputs> <Outputs> <Output id="140" points="2031 89" /> <Output id="138" stoichiometry="3" points="2067 166" /> </Outputs> <Catalysts> <Catalyst id="136" points="2156 74, 2093 57" /> </Catalysts> <Properties> <displayName>Auto-ubiquitination of TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="202510" points="1869 87, 1842 87, 1807 87" position="1842 87" lineWidth="1.0"> <Inputs> <Input id="140" points="1912 87" /> <Input id="142" points="1889 183" /> <Input id="143" stoichiometry="2" points="1908 133" /> </Inputs> <Outputs> <Output id="144" points="1771 87" /> <Output id="145" stoichiometry="2" points="1775 137" /> </Outputs> <Catalysts> <Catalyst id="142" points="1872 183, 1842 169" /> </Catalysts> <Properties> <displayName>Activation of TAK1-TAB2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="202500" points="1639 201, 1609 201, 1576 201" position="1609 201" lineWidth="1.0"> <Inputs> <Input id="147" points="1684 241" /> <Input id="148" stoichiometry="2" points="1671 177" /> </Inputs> <Outputs> <Output id="149" points="1524 242" /> <Output id="150" stoichiometry="2" points="1532 173" /> </Outputs> <Catalysts> <Catalyst id="144" points="1630 88, 1609 88" /> </Catalysts> <Properties> <displayName>Activation of IKK complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="202534" points="1662 346, 1699 346, 1772 346" position="1699 346" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="149" points="1538 284" /> <Input id="153" points="1618 394" /> <Input id="274" points="1615 346" /> </Inputs> <Outputs> <Output id="152" points="1846 398" /> <Output id="153" points="1637 394" /> </Outputs> <Catalysts> <Catalyst id="140" points="1971 117, 1974 314, 1699 318" /> </Catalysts> <Properties> <displayName>Ubiquitination of NEMO by TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="202541" points="1913 612, 1872 612, 1843 612" position="1872 612" lineWidth="1.0"> <Inputs> <Input id="156" points="1939 592" /> <Input id="157" stoichiometry="2" points="1943 627" /> </Inputs> <Outputs> <Output id="305" points="1806 630" /> <Output id="306" stoichiometry="2" points="1803 588" /> </Outputs> <Catalysts> <Catalyst id="152" points="1871 440" /> </Catalysts> <Properties> <displayName>p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="430135" points="1019 1127, 1018 1104, 1018 1074" position="1018 1104" lineWidth="1.0"> <Inputs> <Input id="276" points="1045 1150" /> <Input id="277" points="987 1156" /> </Inputs> <Outputs> <Output id="278" /> </Outputs> <Properties> <displayName>p-SLP-76 binds ADAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="279" reactomeId="430201" points="963 1011, 961 967, 960 927" position="961 967" lineWidth="1.0"> <Inputs> <Input id="280" points="908 1043" /> <Input id="278" points="1005 1046" /> </Inputs> <Outputs> <Output id="281" /> </Outputs> <Properties> <displayName>p-SLP-76:ADAP binds Ena/VASP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="282" reactomeId="430190" points="1145 1128, 1145 1101, 1145 1074" position="1145 1101" lineWidth="1.0"> <Inputs> <Input id="276" points="1105 1150" /> <Input id="283" points="1173 1156" /> </Inputs> <Outputs> <Output id="284" /> </Outputs> <Properties> <displayName>p-SLP-76 binds NCK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="285" reactomeId="430183" points="1183 1023, 1184 993, 1183 961" position="1184 993" lineWidth="1.0"> <Inputs> <Input id="286" points="1219 1044" /> <Input id="284" points="1156 1046" /> </Inputs> <Outputs> <Output id="287" /> </Outputs> <Properties> <displayName>NCK binds PAK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="288" reactomeId="430180" points="1090 925, 1091 873, 1091 836" position="1091 873" lineWidth="1.0"> <Inputs> <Input id="284" points="1140 1046" /> <Input id="289" points="1073 963" /> </Inputs> <Outputs> <Output id="290" /> </Outputs> <Properties> <displayName>NCK recruits WASP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="292" points="1778 1791, 1578 1737, 1317 1786" position="1578 1737" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="47" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="293" points="1584 1819, 1409 1866, 1317 1825" position="1409 1866" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="49" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="294" points="122 1220, 1062 1804" position="592 1512" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="295" points="672 1820, 989 1883, 1057 1852" position="989 1883" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="296" points="3260 1440, 3348 1248, 3262 1151" position="3348 1248" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="59" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="297" points="3291 1257, 3324 1243, 3260 1151" position="3324 1243" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="61" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="298" points="810 1805, 846 1805" position="828 1805" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="40" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="299" points="86 1770, 70 1828, 466 1902, 846 1820" position="268 1865" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="41" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="364" reactomeId="5607728" points="1671 657, 1644 657, 1612 657" position="1644 657" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="365" points="1645 717" /> <Input id="366" stoichiometry="4" points="1744 720" /> <Input id="305" points="1712 657" /> <Input id="367" points="1647 594" /> </Inputs> <Outputs> <Output id="365" points="1633 717" /> <Output id="368" points="1562 657" /> <Output id="367" points="1639 594" /> </Outputs> <Catalysts> <Catalyst id="367" points="1644 594" /> </Catalysts> <Properties> <displayName>beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="369" reactomeId="5607724" points="1426 658, 1387 658, 1358 658" position="1387 658" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="368" /> </Inputs> <Outputs> <Output id="370" /> </Outputs> <Catalysts> <Catalyst id="384" points="1387 550" /> </Catalysts> <Properties> <displayName>26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="382" reactomeId="2730894" points="1225 659, 1188 659, 1149 659" position="1188 659" lineWidth="1.0"> <Inputs> <Input id="370" /> </Inputs> <Outputs> <Output id="383" /> </Outputs> <Properties> <displayName>NFKB1:RELA translocates from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="397" reactomeId="6811491" points="2778 1759, 2795 1767, 2828 1784" position="2795 1767" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="398" points="2727 1796" /> <Input id="399" points="2778 1688" /> </Inputs> <Outputs> <Output id="400" /> </Outputs> <Properties> <displayName>PI5P binds DOK1, DOK2, DOK5 or DOK4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="406" reactomeId="8852200" points="272 278, 410 289, 567 251" position="410 289" lineWidth="1.0"> <Inputs> <Input id="12" points="158 270" /> <Input id="407" points="312 324" /> </Inputs> <Outputs> <Output id="4" points="534 114" /> <Output id="225" points="610 200" /> </Outputs> <Catalysts> <Catalyst id="408" points="410 401" /> </Catalysts> <Properties> <displayName>Inactivation of LCK by PTPN22</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="424" reactomeId="8855375" points="275 413, 285 393, 297 376" position="285 393" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="425" /> </Inputs> <Outputs> <Output id="408" points="376 404" /> <Output id="2" points="172 163" /> </Outputs> <Properties> <displayName>PTPN22 dissociates from CSK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="442" reactomeId="8855381" points="165 797, 171 767, 174 737" position="171 767" lineWidth="1.0"> <Inputs> <Input id="20" points="105 905" /> <Input id="443" points="196 818" /> </Inputs> <Outputs> <Output id="18" points="127 690" /> <Output id="445" points="224 720" /> </Outputs> <Catalysts> <Catalyst id="408" points="408 431, 358 765" /> </Catalysts> <Properties> <displayName>PTPN22 dephosphorylates ZAP70</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="452" reactomeId="199456" points="3161 1443, 3113 1376, 3147 1246" position="3113 1376" lineWidth="1.0"> <Inputs> <Input id="59" points="3210 1451" /> <Input id="456" points="3183 1433" /> </Inputs> <Outputs> <Output id="99" points="3215 1227" /> <Output id="455" points="3174 1269" /> </Outputs> <Catalysts> <Catalyst id="447" points="3057 1373" /> </Catalysts> <Properties> <displayName>PTEN dephosphorylates PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="482" interactionType="Activate" points="3210 1462, 3092 1474" position="3151 1468" lineWidth="2.0"> <Inputs> <Input id="59" /> </Inputs> <Outputs> <Output id="481" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
width3362
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of TCR signaling (453263)
Follow Reactome