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Details on Person SYK autophosphorylates

Class:IdReaction:453200
_displayNameSYK autophosphorylates
_doReleaseTRUE
_timestamp2015-07-28 14:28:00
authored[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity[CatalystActivity:453196] non-membrane spanning protein tyrosine kinase activity of GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:453180] Jupe, S, 2010-01-19
edited[InstanceEdit:870306] Jupe, S, 2010-06-07
input[Complex:434911] GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:453203] Conformational rearrangements upon Syk auto-phosphorylation
[LiteratureReference:453181] Structure and function of Syk protein-tyrosine kinase
[LiteratureReference:453177] Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis
modified[InstanceEdit:870420] Jupe, S, 2010-06-08
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:6788924] Jupe, Steve, 2015-07-28
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSYK autophosphorylates
output[Complex:453171] GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:5684192] Negative regulation by 'G6B:PTPN6,PTPN11 [plasma membrane]'
regulationReference[RegulationReference:9642577] Negative regulation by 'G6B:PTPN6,PTPN11 [plasma membrane]' G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2
releaseDate2010-09-21
reviewed[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104213] R-HSA-453200.5
summation[Summation:453179] Binding of Syk causes conformational changes that lead to Sy...
(hasEvent)[Pathway:114604] GPVI-mediated activation cascade [Homo sapiens]
(precedingEvent)[Reaction:453183] p-Y348-SYK dissociates [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784601] Update Tracker - [Reaction:453200] SYK autophosphorylates - v53:[addRegulator, modifyText]
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No pathways have been reviewed or authored by SYK autophosphorylates (453200)