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Details on Person Phosphorylated SHC recruits GRB2:SOS1

Class:Id	Reaction:453111
_displayName	Phosphorylated SHC recruits GRB2:SOS1
_doRelease	TRUE
_timestamp	2011-06-02 11:29:58
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:453095] Jupe, S, 2010-01-18
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[DefinedSet:912534] Interleukin receptor complexes with activated SHC1 [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:453092] Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases [LiteratureReference:453090] The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation
modified	[InstanceEdit:507917] Jupe, S, 2010-02-09 [InstanceEdit:508240] Jupe, S, 2010-02-11 [InstanceEdit:508254] Jupe, S, 2010-02-11 [InstanceEdit:912521] Jupe, S, 2010-07-09 [InstanceEdit:912541] Jupe, S, 2010-07-09 [InstanceEdit:912563] Jupe, S, 2010-07-09 [InstanceEdit:914195] Jupe, S, 2010-07-23 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:921160] Jupe, S, 2010-08-05 [InstanceEdit:926765] Jupe, S, 2010-08-06 [InstanceEdit:926778] Jupe, S, 2010-08-06 [InstanceEdit:926780] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated SHC recruits GRB2:SOS1
output	[Complex:921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens] [Reaction:452100] SHC1 bound to IL2 receptor is phosphorylated [Homo sapiens] [Reaction:452091] Phosphorylation of IL2RB Y338 enables SHC recruitment [Homo sapiens] [Reaction:879925] SHC1 bound to the common beta chain becomes tyrosine phosphorylated [Homo sapiens] [Reaction:879934] Recruitment of SHC1 is mediated by Y593 of the common beta chain [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104180] R-HSA-453111.2
summation	[Summation:507924] Shc is tyrosine phosphorylated by an unidentified kinase, cr...
(hasEvent)	[Pathway:912526] Interleukin receptor SHC signaling [Homo sapiens]
(precedingEvent)	[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylated SHC recruits GRB2:SOS1 (453111)