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Details on Person Jupe, S, 2010-01-18
| Class:Id | InstanceEdit:453095 |
| _displayName | Jupe, S, 2010-01-18 |
| _timestamp | 2010-01-18 15:20:11 |
| author | [Person:391309] Jupe, Steve |
| dateTime | 2010-01-18 20:19:26 |
| (created) | [Person:453089] Suen, KL [LiteratureReference:453090] The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation [CatalystActivity:453091] protein tyrosine kinase activity of SHC kinases in IL2 signaling [cytosol] [LiteratureReference:453092] Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases [Complex:453093] IL2:IL2R trimer p-(Y338)-beta subunit:p-JAK1:JAK3:p-SHC:GRB2:SOS [plasma membrane] [Homo sapiens] [Person:453094] Weiler, SR [LiteratureReference:453096] Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc [Person:453097] Howard, OM [Person:453098] Thomas, S [Complex:453099] IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] [Homo sapiens] |
| (modified) | [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens] [Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS [Homo sapiens] [DefinedSet:434838] p-Y348-SYK/LCK [cytosol] [Homo sapiens] [Pathway:451927] Interleukin-2 family signaling [Homo sapiens] [Reaction:452091] Phosphorylation of IL2RB Y338 enables SHC recruitment [Homo sapiens] [Reaction:452100] SHC1 bound to IL2 receptor is phosphorylated [Homo sapiens] |
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No pathways have been reviewed or authored by Jupe, S, 2010-01-18 (453095)