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Details on Person Expression of SOX2
Class:Id BlackBoxEvent:452894 _displayName Expression of SOX2 _doRelease TRUE _timestamp 2018-11-20 03:45:18 authored [InstanceEdit:1013049] May, B, 2010-11-12 compartment [Compartment:7660] nucleoplasm created [InstanceEdit:452990] May, B, 2010-01-15 edited [InstanceEdit:1013049] May, B, 2010-11-12 input [EntityWithAccessionedSequence:2888991] SOX2 gene [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:452879] Comparative transcriptional profiling of two human embryonic stem cell lines [LiteratureReference:452256] Induction of pluripotent stem cells from adult human fibroblasts by defined factors [LiteratureReference:452197] Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells [LiteratureReference:453016] The transcriptome profile of human embryonic stem cells as defined by SAGE [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452756] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:480315] Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal modified [InstanceEdit:500370] May, B, 2010-02-03 [InstanceEdit:561173] May, B, 2010-03-30 [InstanceEdit:1013055] May, B, 2010-11-12 [InstanceEdit:1086967] May, B, 2010-11-29 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2889038] May, B, 2012-12-31 [InstanceEdit:2892244] May, B, 2012-12-31 [InstanceEdit:2972981] D'Eustachio, P, 2013-01-06 [InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5163242] D'Eustachio, P, 2013-11-23 [InstanceEdit:5246709] May, B, 2014-01-22 [InstanceEdit:5246733] May, B, 2014-01-23 [InstanceEdit:5638458] May, Bruce, 2014-11-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627001] May, Bruce, 2018-10-31 [InstanceEdit:9629283] May, Bruce, 2018-11-20 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Expression of SOX2 output [EntityWithAccessionedSequence:452271] SOX2 [nucleoplasm] [Homo sapiens] precedingEvent
regulatedBy [PositiveGeneExpressionRegulation:480853] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' [PositiveGeneExpressionRegulation:5638454] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]' regulationReference [RegulationReference:9641200] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]' Comparative transcriptional profiling of two human embryonic stem cell lines [RegulationReference:9642690] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions releaseDate 2014-03-12 reviewed [InstanceEdit:5246708] Wang, Jianlong, 2014-01-22 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:5644879] R-HSA-452894.6 summation [Summation:500382] The SOX2 gene is transcribed to yield mRNA and the mRNA is t... (hasEvent) [Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens] [Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens] (precedingEvent) [Reaction:480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter [Homo sapiens] [Reaction:480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter [Homo sapiens] [BlackBoxEvent:480788] Expression of ZSCAN10 (ZNF206) [Homo sapiens] [Reaction:1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter [Homo sapiens] [Reaction:2972946] POU5F1 (OCT4), SOX2, NANOG Bind the TNC Promoter [Homo sapiens] [Reaction:2972947] POU5F1 (OCT4), SOX2, NANOG Bind the ORC1 Promoter [Homo sapiens] [Reaction:2972948] POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter [Homo sapiens] [Reaction:2972949] POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter [Homo sapiens] [Reaction:2972950] POU5F1 (OCT4), SOX2 Bind the PIP5K1C Promoter [Homo sapiens] [Reaction:2972951] POU5F1 (OCT4), SOX2, NANOG Bind the KDR Promoter [Homo sapiens] (updatedInstance) [_UpdateTracker:9777978] Update Tracker - [BlackBoxEvent:452894] Expression of SOX2 - v68:[removeCatalystActivity] [_UpdateTracker:9785773] Update Tracker - [BlackBoxEvent:452894] Expression of SOX2 - v51:[addCatalystActivity, addRegulator, add_removeInput]
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